Principal Investigators

Peter Rogan, Ph.D. (progan {@}, Director of the Laboratory of Human Molecular Genetics, is a Professor in Biochemistry at Schulich School of Medicine and Dentistry at the University of Western Ontario. He is co-appointed in the Department of Computer Science in the Faculty of Science. nbsp; Dr. Rogan is a molecular biologist with a strong record of accomplishments in human genetics and computational molecular biology.  He has made significant contributions to the study of genotype-phenotype relationships in a variety of inherited and imprinted disorders, and, together with Dr. Thomas Schneider, proposed and applied the concept of information analysis to the systematic analysis of human mutations.  Dr. Rogan has established an independent and continuous record of accomplishments in several areas including computational biology, image processing of molecular biological data, genetic database construction, linkage analysis, molecular evolution, and cytogenomics.

Joan H. Knoll, Ph.D., (jknoll3 {@}, Director of the Laboratory of Genomic Disorders, is Professor of Pathology at the University of Western Ontario and is board certified by the American College of Medical Genetics in Cytogenetics and Molecular Genetics. She is also Medical Leader in Molecular Pathology at London Health Sciences Center and She has directed clinical cytogenetics laboratories at several academic research institutions since 1991. Dr. Knoll authored the first article describing in situ hybridization (ISH) in Current Protocols in Human Genetics, a primary reference for genetics laboratories worldwide; has developed numerous improvements in ISH since the late 1980's; and most recently has co-invented with Dr. Rogan a method of developing single copy DNA probes from the human genome sequence and using these probes for FISH. She is currently directing an NCI funded project to precisely define chromosome abnormalities in chronic myelogenous leukemia.