Gene: ROR2
mRNA Accession: M97639
Mutation:ROR2.txt
Chromosome: chr 9

Sequence Walker  




1096C>T


Instruction: g87792413a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87792381 -56 87792325 2.7 2.7 0.0 1.0 100 -1.6 -1.6 0.0



1189C>T


Instruction: g87788154a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87788200 -40 87788160 0.7 0.7 0.0 1.0 100 -2.2 -2.2 0.0
Increased 87788159 1 87788160 -0.1 1.3 1.4 2.5 249.3 -2.5 -2.0 0.4



1321_1325del


Instruction: d87788018,87788022; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87788062 98 87788160 1.2 1.2 0.0 1.0 100 -2.1 -2.1 0.0



1398_1399insA


Instruction: i87786511,87786512t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87786557 -33 87786524 1.4 1.4 0.0 1.0 100 -2.0 -2.0 0.0
No change 87786545 -21 87786524 4.3 4.3 0.0 1.0 100 -1.1 -1.1 0.0
No change 87786493 31 87786524 7.4 7.4 0.0 1.0 100 -0.2 -0.2 0.0
No change 87786488 36 87786524 0.9 0.9 0.0 1.0 100 -2.2 -2.2 0.0



1504C>T


Instruction: g87786406a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87786455 69 87786524 0.8 0.8 0.0 1.0 100 -2.2 -2.2 0.0
No change 87786441 83 87786524 1.9 1.9 0.0 1.0 100 -1.9 -1.9 0.0
No change 87786417 107 87786524 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0



1740_1774del
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z )Δ Z
Decreased 87786163 361 87786524 4.9 0.0 -4.9 -29.4 3.4 -1.0 0.0 1.0



1860T>A


Instruction: a87786050t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87786079 445 87786524 1.6 1.6 0.0 1.0 100 -2.0 -2.0 0.0
Increased 87786049 475 87786524 0.7 0.9 0.3 1.2 119.8 -2.2 -2.1 0.1
No change 87786041 483 87786524 2.1 2.1 0.0 1.0 100 -1.8 -1.8 0.0
No change 87786025 499 87786524 3.4 3.4 0.0 1.0 100 -1.4 -1.4 0.0



2160G>A


Instruction: c87785750t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87785786 738 87786524 1.1 1.1 0.0 1.0 100 -2.1 -2.1 0.0
No change 87785782 742 87786524 3.9 3.9 0.0 1.0 100 -1.2 -1.2 0.0
Increased 87785747 777 87786524 1.2 2.2 1.0 2.0 200.3 -2.1 -1.8 0.3
Decreased 87785749 775 87786524 2.2 -0.8 -3.1 -4.7 NA -1.8 -2.7 -0.9



498T>C


Instruction: a87798931g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87798950 -15 87798935 1.7 1.7 0.0 1.0 100 -1.9 -1.9 0.0



498T>C
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z )Δ Z
Increased 87798884 51 87798935 -0.6 0.8 1.4 1.7 174.6 -2.6 -2.2 0.4



613C>T


Instruction: g87798816a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87798806 0 87798806 9.0 9.0 0.0 1.0 100 0.3 0.3 0.0



IVS8+3_5delins19


Instruction: d87787952,87787954; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87787928 28 87787956 3.3 3.3 0.0 1.0 100 -1.4 -1.4 0.0
Increased 87787956 0 87787956 -0.5 2.6 3.1 6.0 598.3 -2.6 -1.6 0.9

Legend:    Site Abolished   Leaky Site   Cryptic Site created   Strengthened Pre-existing site   Pre-existing Site   Weakened Pre-existing Site