Gene: ROR2
mRNA Accession: M97639
Mutation:ROR2.txt
Chromosome: chr 9

Sequence Walker  




1096C>T


Instruction: g87792413a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87792431 -106 87792325 1.6 1.6 0.0 1.0 100 -1.6 -1.6 0.0
No change 87792369 -44 87792325 3.6 3.6 0.0 1.0 100 -1.1 -1.1 0.0



1189C>T


Instruction: g87788154a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87788160 0 87788160 7.2 7.2 0.0 1.0 100 -0.4 -0.4 0.0
No change 87788111 49 87788160 4.6 4.6 0.0 1.0 100 -0.9 -0.9 0.0



1321_1325del


Instruction: d87788018,87788022; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 87788023 137 87788160 2.2 2.8 0.5 1.4 144.9 -1.5 -1.3 0.1
No change 87787966 194 87788160 1.1 1.1 0.0 1.0 100 -1.7 -1.7 0.0



1398_1399insA


Instruction: i87786511,87786512t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87786524 0 87786524 9.6 9.6 0.0 1.0 100 0.2 0.2 0.0



1740_1774del


Instruction: d87786136,87786170; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 87786116 408 87786524 4.8 2.6 -2.2 -4.5 22.4 -0.9 -1.4 -0.5



2246G>A


Instruction: c87785664t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87785690 834 87786524 3.5 3.5 0.0 1.0 100 -1.2 -1.2 0.0
Increased 87785640 884 87786524 1.0 1.4 0.4 1.3 130.5 -1.7 -1.6 0.1
Increased 87785663 861 87786524 -7.0 1.2 8.2 2.3 230.3 -3.5 -1.7 1.8



2249delG


Instruction: d87785661,87785661; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87785690 834 87786524 3.5 3.5 0.0 1.0 100 -1.2 -1.2 0.0
Increased 87785640 884 87786524 1.0 1.9 0.9 1.8 182.4 -1.7 -1.5 0.2



2265C>A
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z )Δ Z
Decreased 87785640 884 87786524 1.0 -1.4 -2.5 -2.1 NA -1.7 -2.3 -0.5



2278C>T


Instruction: g87785632a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87785640 884 87786524 1.0 1.0 0.0 1.0 100 -1.7 -1.7 0.0
No change 87785583 941 87786524 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0



498T>C


Instruction: a87798931g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87798956 -21 87798935 2.0 2.0 0.0 1.0 100 -1.5 -1.5 0.0
No change 87798935 0 87798935 9.1 9.1 0.0 1.0 100 0.1 0.1 0.0



545G>A


Instruction: c87798884t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87798838 97 87798935 3.8 3.8 0.0 1.0 100 -1.1 -1.1 0.0
No change 87798832 103 87798935 5.0 5.0 0.0 1.0 100 -0.9 -0.9 0.0



550C>T


Instruction: g87798879a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87798838 97 87798935 3.8 3.8 0.0 1.0 100 -1.1 -1.1 0.0
No change 87798832 103 87798935 5.0 5.0 0.0 1.0 100 -0.9 -0.9 0.0



565C>T


Instruction: g87798864a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87798838 -32 87798806 3.8 3.8 0.0 1.0 100 -1.1 -1.1 0.0
No change 87798832 -26 87798806 5.0 5.0 0.0 1.0 100 -0.9 -0.9 0.0



613C>T


Instruction: g87798816a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87798838 -32 87798806 3.8 3.8 0.0 1.0 100 -1.1 -1.1 0.0
No change 87798832 -26 87798806 5.0 5.0 0.0 1.0 100 -0.9 -0.9 0.0
No change 87798781 25 87798806 5.7 5.7 0.0 1.0 100 -0.7 -0.7 0.0



IVS8+3_5delins19


Instruction: d87787952,87787954; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 87787966 -10 87787956 1.1 1.1 0.0 1.0 100 -1.7 -1.7 0.0
No change 87787957 -1 87787956 0.4 0.4 0.0 1.0 100 -1.9 -1.9 0.0
Decreased 87787930 26 87787956 3.2 1.0 -2.3 -4.8 20.6 -1.2 -1.7 -0.5
Decreased 87787929 27 87787956 3.3 1.6 -1.6 -3.1 31.9 -1.2 -1.6 -0.4
No change 87787916 40 87787956 8.9 8.9 0.0 1.0 100 0.0 0.0 0.0
No change 87787903 53 87787956 6.6 6.6 0.0 1.0 100 -0.5 -0.5 0.0

Legend:    Site Abolished   Leaky Site   Cryptic Site created   Strengthened Pre-existing site   Pre-existing Site   Weakened Pre-existing Site