Gene: PAH
mRNA Accession: U49897
Mutation:PAH.txt
Chromosome: chr 12

Sequence Walker  


Decrease of Information Content
Mutation SubmittedMutation InstructionGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
IVS1nt5g>t
Sequence Walker 		c103243791a 103243795 0 103243795 10.7 6.8 -3.9 -15.1 6.6 0.8 -0.4 -1.2
IVS2nt1g>a
Sequence Walker   		c103239515t 103239515 0 103239515 7.2 -5.6 -12.8 -144.4 NA -0.3 -4.1 -3.9
IVS2nt5g>c
Sequence Walker 		c103239511g 103239515 0 103239515 7.2 3.2 -3.9 -15.5 6.4 -0.3 -1.5 -1.2
IVS2nt5g>t
Sequence Walker 		c103239511a 103239515 0 103239515 7.2 3.3 -3.9 -15.1 6.6 -0.3 -1.4 -1.2
IVS2nt6t>g
Sequence Walker 		a103239510c 103239515 0 103239515 7.2 6.0 -1.2 -2.3 42.8 -0.3 -0.6 -0.4
IVS2nt19t>c
Sequence Walker   		a103239497g 103239498 17 103239515 1.6 -5.9 -7.5 -3.0 NA -1.9 -4.2 -2.3
IVS4nt1g>a
Sequence Walker   		c103204186t 103204186 0 103204186 6.8 -6.0 -12.8 -109.9 NA -0.4 -4.3 -3.9
IVS5nt1delg
Sequence Walker   		d103193320,103193320 103193320 0 103193320 7.4 -7.5 -15.0 -173.8 NA -0.2 -4.7 -4.5
IVS5nt1g>a
Sequence Walker   		c103193320t 103193320 0 103193320 7.4 -5.4 -12.8 -173.8 NA -0.2 -4.1 -3.9
IVS5nt5delg
Sequence Walker 		d103193316,103193316 103193320 0 103193320 7.4 1.8 -5.7 -50.4 1.9 -0.2 -1.9 -1.7
IVS7nt1g>a
Sequence Walker   		c103179539t 103179539 0 103179539 6.1 -6.7 -12.8 -68.8 NA -0.6 -4.5 -3.9
IVS7nt2t>a
Sequence Walker   		a103179538t 103179539 0 103179539 6.1 -1.7 -7.8 -68.8 NA -0.6 -2.9 -2.4
IVS7nt5g>a
Sequence Walker 		c103179535t 103179539 0 103179539 6.1 2.6 -3.5 -11.5 8.7 -0.6 -1.6 -1.1
IVS8nt1g>a
Sequence Walker   		c103178411t 103178411 0 103178411 11.5 -1.3 -12.8 -2922.7 NA 1.1 -2.8 -3.9
IVS9nt6t>a
Sequence Walker 		a103173614t 103173619 0 103173619 7.3 5.7 -1.6 -3.0 33.2 -0.2 -0.7 -0.5
IVS10nt1g>a
Sequence Walker   		c103171060t 103171060 0 103171060 7.8 -5.0 -12.8 -228.6 NA -0.1 -3.9 -3.9
IVS10nt3a>g
Sequence Walker 		t103171058c 103171060 0 103171060 7.8 7.4 -0.4 -1.3 75.7 -0.1 -0.2 -0.1
IVS11nt1g>a
Sequence Walker 		c103170370t 103170375 -5 103170370 7.8 7.4 -0.4 -1.3 77.5 -0.1 -0.2 -0.1
IVS11nt1g>a
Sequence Walker   		c103170370t 103170370 0 103170370 10.4 -2.4 -12.8 -1372.3 NA 0.7 -3.2 -3.9
IVS11nt1g>c
Sequence Walker 		c103170370g 103170375 -5 103170370 7.8 7.6 -0.2 -1.1 87.3 -0.1 -0.1 -0.1
IVS11nt1g>c
Sequence Walker 		c103170370g 103170370 0 103170370 10.4 0.6 -9.8 -894.5 0.1 0.7 -2.2 -3.0
IVS11nt20g>c
Sequence Walker 		c103170351g 103170353 17 103170370 10.5 6.1 -4.4 -21.1 4.7 0.8 -0.6 -1.3
IVS12nt2t>c
Sequence Walker 		a103167123g 103167124 0 103167124 7.5 0.0 -7.5 -177.5 0.5 -0.2 -2.4 -2.3
IVS12nt-5t>c
Sequence Walker 		a103165948g 103165947 -3 103165944 3.5 2.8 -0.7 -1.7 60.2 -1.4 -1.6 -0.2
IVS12nt-35c>t
Sequence Walker   		g103165978a 103165975 -31 103165944 1.1 -0.5 -1.6 -2.2 NA -2.1 -2.6 -0.5