All Mutations grouped

Gene:	PAH
mRNA Accession:	U49897
Chromosome:	chr 12
Sequence Walker

IVS1nt5g>t

Instruction: c103243791a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	103243796	-1	103243795	2.3	2.3	0.0	1.0	100	-1.4	-1.4	0.0
No Change	103243746	49	103243795	1.9	1.9	0.0	1.0	100	-1.5	-1.5	0.0
Sites found for donor
No Change	103243817	-22	103243795	0.8	0.8	0.0	1.0	100	-2.2	-2.2	0.0
Decreased	103243795	0	103243795	10.7	6.8	-3.9	-15.1	6.6	0.8	-0.4	-1.2
No Change	103243768	27	103243795	0.7	0.7	0.0	1.0	100	-2.2	-2.2	0.0
No Change	103243767	28	103243795	1.5	1.5	0.0	1.0	100	-2.0	-2.0	0.0

IVS2nt1g>a

Instruction: c103239515t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	103239476	39	103239515	0.9	0.9	0.0	1.0	100	-1.7	-1.7	0.0
Sites found for donor
No Change	103239551	-36	103239515	1.8	1.8	0.0	1.0	100	-1.9	-1.9	0.0
No Change	103239547	-32	103239515	1.5	1.5	0.0	1.0	100	-2.0	-2.0	0.0
No Change	103239533	-18	103239515	1.1	1.1	0.0	1.0	100	-2.1	-2.1	0.0
No Change	103239498	17	103239515	1.6	1.6	0.0	1.0	100	-1.9	-1.9	0.0
Decreased	103239515	0	103239515	7.2	-5.6	-12.8	-144.4	NA	-0.3	-4.1	-3.9

IVS2nt5g>c

Instruction: c103239511g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	103239476	39	103239515	0.9	0.9	0.0	1.0	100	-1.7	-1.7	0.0
Sites found for donor
No Change	103239551	-36	103239515	1.8	1.8	0.0	1.0	100	-1.9	-1.9	0.0
No Change	103239547	-32	103239515	1.5	1.5	0.0	1.0	100	-2.0	-2.0	0.0
No Change	103239533	-18	103239515	1.1	1.1	0.0	1.0	100	-2.1	-2.1	0.0
Decreased	103239515	0	103239515	7.2	3.2	-3.9	-15.5	6.4	-0.3	-1.5	-1.2
No Change	103239498	17	103239515	1.6	1.6	0.0	1.0	100	-1.9	-1.9	0.0

IVS2nt5g>t

Instruction: c103239511a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	103239476	39	103239515	0.9	0.9	0.0	1.0	100	-1.7	-1.7	0.0
Sites found for donor
No Change	103239551	-36	103239515	1.8	1.8	0.0	1.0	100	-1.9	-1.9	0.0
No Change	103239547	-32	103239515	1.5	1.5	0.0	1.0	100	-2.0	-2.0	0.0
No Change	103239533	-18	103239515	1.1	1.1	0.0	1.0	100	-2.1	-2.1	0.0
Decreased	103239515	0	103239515	7.2	3.3	-3.9	-15.1	6.6	-0.3	-1.4	-1.2
No Change	103239498	17	103239515	1.6	1.6	0.0	1.0	100	-1.9	-1.9	0.0

IVS2nt6t>g

Instruction: a103239510c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	103239476	39	103239515	0.9	0.9	0.0	1.0	100	-1.7	-1.7	0.0
increased	103239511	4	103239515	-0.8	1.4	2.2	2.7	266.0	-2.1	-1.6	0.5
Sites found for donor
No Change	103239551	-36	103239515	1.8	1.8	0.0	1.0	100	-1.9	-1.9	0.0
No Change	103239547	-32	103239515	1.5	1.5	0.0	1.0	100	-2.0	-2.0	0.0
No Change	103239533	-18	103239515	1.1	1.1	0.0	1.0	100	-2.1	-2.1	0.0
Decreased	103239515	0	103239515	7.2	6.0	-1.2	-2.3	42.8	-0.3	-0.6	-0.4
No Change	103239498	17	103239515	1.6	1.6	0.0	1.0	100	-1.9	-1.9	0.0

IVS2nt19t>c

Instruction: a103239497g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	103239476	39	103239515	0.9	0.9	-0.1	-1.0	96.1	-1.7	-1.7	-0.0
No Change	103239453	62	103239515	8.5	8.5	0.0	1.0	100	-0.1	-0.1	0.0
No Change	103239449	66	103239515	7.9	7.9	0.0	1.0	100	-0.2	-0.2	0.0
Sites found for donor
No Change	103239547	-32	103239515	1.5	1.5	0.0	1.0	100	-2.0	-2.0	0.0
No Change	103239533	-18	103239515	1.1	1.1	0.0	1.0	100	-2.1	-2.1	0.0
No Change	103239515	0	103239515	7.2	7.2	0.0	1.0	100	-0.3	-0.3	0.0
No Change	103239453	62	103239515	0.9	0.9	0.0	1.0	100	-2.1	-2.1	0.0
Decreased	103239498	17	103239515	1.6	-5.9	-7.5	-3.0	NA	-1.9	-4.2	-2.3
increased	103204284	35231	103239515	-1.8	1.3	3.1	2.4	239.4	-3.0	-2.1	0.9

IVS3nt-22c>t

Instruction: g103204297a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	103204300	-24	103204276	4.9	4.9	0.0	1.0	100	-0.9	-0.9	0.0
Increased	103204276	0	103204276	7.6	7.6	0.1	1.0	104.0	-0.3	-0.3	0.0
No Change	103204269	7	103204276	1.3	1.3	0.0	1.0	100	-1.7	-1.7	0.0
No Change	103204261	15	103204276	0.5	0.5	0.0	1.0	100	-1.8	-1.8	0.0
No Change	103204260	16	103204276	3.3	3.3	0.0	1.0	100	-1.2	-1.2	0.0
Sites found for donor

IVS3nt-6t>a

Instruction: a103204281t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	103204300	-24	103204276	4.9	4.9	0.0	1.0	100	-0.9	-0.9	0.0
Decreased	103204276	0	103204276	7.6	4.9	-2.7	-6.4	15.6	-0.3	-0.9	-0.6
Decreased	103204260	16	103204276	3.3	2.9	-0.4	-1.3	74.2	-1.2	-1.3	-0.1
Decreased	103204269	7	103204276	1.3	-1.2	-2.5	-2.5	NA	-1.7	-2.2	-0.5
Decreased	103204261	15	103204276	0.5	-0.4	-0.9	-1.5	NA	-1.8	-2.0	-0.2
Sites found for donor

IVS4nt1g>a

Instruction: c103204186t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	103204168	18	103204186	4.4	4.2	-0.2	-1.2	86.5	-1.0	-1.0	-0.0
No Change	103204138	48	103204186	2.0	2.0	0.0	1.0	100	-1.5	-1.5	0.0
Sites found for donor
No Change	103204171	15	103204186	2.0	2.0	0.0	1.0	100	-1.8	-1.8	0.0
Decreased	103204186	0	103204186	6.8	-6.0	-12.8	-109.9	NA	-0.4	-4.3	-3.9

IVS4nt-1g>a

Instruction: c103193389t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	103193389	0	103193389	10.8	3.3	-7.6	-191.1	0.5	0.4	-1.2	-1.7
Increased	103193388	1	103193389	1.5	9.6	8.2	286.2	28616.6	-1.6	0.2	1.8
Decreased	103193379	10	103193389	4.9	4.4	-0.4	-1.4	73.8	-0.9	-1.0	-0.1
increased	103193387	2	103193389	-1.5	0.2	1.7	1.2	118.8	-2.3	-1.9	0.4
Sites found for donor
No Change	103193406	-17	103193389	5.1	5.1	0.0	1.0	100	-0.9	-0.9	0.0

IVS4nt-5c>g

Instruction: g103193393c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	103193421	-32	103193389	1.6	1.6	0.0	1.0	100	-1.6	-1.6	0.0
Decreased	103193389	0	103193389	10.8	8.3	-2.5	-5.7	17.4	0.4	-0.1	-0.6
Decreased	103193379	10	103193389	4.9	3.6	-1.3	-2.5	40.5	-0.9	-1.2	-0.3
Decreased	103193388	1	103193389	1.5	-1.2	-2.7	-2.8	NA	-1.6	-2.2	-0.6
Sites found for donor
No Change	103193443	-54	103193389	4.4	4.4	0.0	1.0	100	-1.1	-1.1	0.0
No Change	103193406	-17	103193389	5.1	5.1	0.0	1.0	100	-0.9	-0.9	0.0

IVS5nt1delg

Instruction: d103193320,103193320 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	103193298	22	103193320	2.6	2.7	0.0	1.0	103.2	-1.4	-1.3	0.0
Decreased	103193320	0	103193320	0.4	-13.3	-13.7	-1.4	NA	-1.8	-4.8	-3.0
Sites found for donor
No Change	103193296	24	103193320	0.9	0.9	0.0	1.0	100	-2.2	-2.2	0.0
Decreased	103193320	0	103193320	7.4	-7.5	-15.0	-173.8	NA	-0.2	-4.7	-4.5

IVS5nt1g>a

Instruction: c103193320t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	103193298	22	103193320	2.6	3.1	0.4	1.4	135.5	-1.4	-1.3	0.1
Decreased	103193320	0	103193320	0.4	-7.1	-7.6	-1.4	NA	-1.8	-3.5	-1.7
Sites found for donor
No Change	103193296	24	103193320	0.9	0.9	0.0	1.0	100	-2.2	-2.2	0.0
Decreased	103193320	0	103193320	7.4	-5.4	-12.8	-173.8	NA	-0.2	-4.1	-3.9

IVS5nt5delg

Instruction: d103193316,103193316 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	103193320	0	103193320	0.4	0.4	0.0	1.0	100	-1.8	-1.8	0.0
Decreased	103193298	22	103193320	2.6	2.3	-0.4	-1.3	77.4	-1.4	-1.4	-0.1
Sites found for donor
Decreased	103193320	0	103193320	7.4	1.8	-5.7	-50.4	1.9	-0.2	-1.9	-1.7
No Change	103193296	24	103193320	0.9	0.9	0.0	1.0	100	-2.2	-2.2	0.0

IVS5nt54c>g

Instruction: g103193267c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	103193250	70	103193320	1.8	0.5	-1.3	-2.5	40.3	-1.5	-1.8	-0.3
Decreased	103193246	74	103193320	11.0	10.0	-1.0	-2.1	48.5	0.5	0.2	-0.2
No Change	103193241	79	103193320	3.0	3.0	0.0	1.0	100	-1.3	-1.3	0.0
Decreased	103193257	63	103193320	0.6	-1.1	-1.7	-1.5	NA	-1.8	-2.2	-0.4
Decreased	103193243	77	103193320	0.3	-0.7	-1.0	-1.2	NA	-1.9	-2.1	-0.2
Sites found for donor
No Change	103193296	24	103193320	0.9	0.9	0.0	1.0	100	-2.2	-2.2	0.0
No Change	103193245	75	103193320	3.3	3.3	0.0	1.0	100	-1.4	-1.4	0.0

IVS6nt-1g>a

Instruction: c103179676t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	103179681	-5	103179676	5.4	5.4	0.0	1.0	100	-0.7	-0.7	0.0
Decreased	103179676	0	103179676	14.7	7.1	-7.6	-191.1	0.5	1.3	-0.4	-1.7
No Change	103179669	7	103179676	2.2	2.2	0.0	1.0	100	-1.5	-1.5	0.0
Decreased	103179667	9	103179676	1.9	1.5	-0.4	-1.3	74.8	-1.5	-1.6	-0.1
Increased	103179654	22	103179676	0.6	1.1	0.4	1.4	135.5	-1.8	-1.7	0.1
No Change	103179627	49	103179676	2.0	2.0	0.0	1.0	100	-1.5	-1.5	0.0
No Change	103179626	50	103179676	2.2	2.2	0.0	1.0	100	-1.5	-1.5	0.0
increased	103179675	1	103179676	-5.1	3.0	8.2	8.2	816.9	-3.1	-1.3	1.8
increased	103179672	4	103179676	-0.2	0.1	0.3	1.0	104.5	-2.0	-1.9	0.1
Sites found for donor
No Change	103179714	-38	103179676	3.9	3.9	0.0	1.0	100	-1.2	-1.2	0.0
No Change	103179649	27	103179676	0.9	0.9	0.0	1.0	100	-2.2	-2.2	0.0

IVS6nt-2a>g

Instruction: t103179677c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	103179681	-5	103179676	5.4	5.4	0.0	1.0	100	-0.7	-0.7	0.0
Decreased	103179676	0	103179676	14.7	6.5	-8.2	-286.2	0.3	1.3	-0.5	-1.8
Increased	103179669	7	103179676	2.2	2.5	0.3	1.2	123.0	-1.5	-1.4	0.1
Increased	103179667	9	103179676	1.9	2.4	0.4	1.4	135.4	-1.5	-1.4	0.1
Decreased	103179654	22	103179676	0.6	0.3	-0.3	-1.2	80.5	-1.8	-1.9	-0.1
No Change	103179627	49	103179676	2.0	2.0	0.0	1.0	100	-1.5	-1.5	0.0
No Change	103179626	50	103179676	2.2	2.2	0.0	1.0	100	-1.5	-1.5	0.0
increased	103179677	-1	103179676	-0.5	7.0	7.6	130.8	13079.4	-2.1	-0.4	1.7
Sites found for donor
No Change	103179714	-38	103179676	3.9	3.9	0.0	1.0	100	-1.2	-1.2	0.0
No Change	103179649	27	103179676	0.9	0.9	0.0	1.0	100	-2.2	-2.2	0.0

IVS7nt1g>a

Instruction: c103179539t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	103179522	17	103179539	4.9	5.0	0.1	1.1	109.8	-0.9	-0.8	0.0
Increased	103179515	24	103179539	4.0	4.4	0.4	1.3	130.5	-1.1	-1.0	0.1
No Change	103179508	31	103179539	3.7	3.7	0.0	1.0	100	-1.1	-1.1	0.0
Sites found for donor
No Change	103179581	-42	103179539	0.7	0.7	0.0	1.0	100	-2.2	-2.2	0.0
No Change	103179554	-15	103179539	1.2	1.2	0.0	1.0	100	-2.1	-2.1	0.0
Decreased	103179539	0	103179539	6.1	-6.7	-12.8	-68.8	NA	-0.6	-4.5	-3.9

IVS7nt2t>a

Instruction: a103179538t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	103179522	17	103179539	4.9	3.5	-1.4	-2.7	37.3	-0.9	-1.2	-0.3
Decreased	103179515	24	103179539	4.0	3.4	-0.6	-1.6	64.3	-1.1	-1.2	-0.1
No Change	103179508	31	103179539	3.7	3.7	0.0	1.0	100	-1.1	-1.1	0.0
Sites found for donor
No Change	103179581	-42	103179539	0.7	0.7	0.0	1.0	100	-2.2	-2.2	0.0
No Change	103179554	-15	103179539	1.2	1.2	0.0	1.0	100	-2.1	-2.1	0.0
Decreased	103179539	0	103179539	6.1	-1.7	-7.8	-68.8	NA	-0.6	-2.9	-2.4

IVS7nt5g>a

Instruction: c103179535t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	103179522	17	103179539	4.9	4.4	-0.5	-1.5	68.5	-0.9	-1.0	-0.1
Increased	103179515	24	103179539	4.0	4.3	0.3	1.2	122.1	-1.1	-1.0	0.1
No Change	103179508	31	103179539	3.7	3.7	0.0	1.0	100	-1.1	-1.1	0.0
Sites found for donor
No Change	103179581	-42	103179539	0.7	0.7	0.0	1.0	100	-2.2	-2.2	0.0
No Change	103179554	-15	103179539	1.2	1.2	0.0	1.0	100	-2.1	-2.1	0.0
Decreased	103179539	0	103179539	6.1	2.6	-3.5	-11.5	8.7	-0.6	-1.6	-1.1

IVS7nt-2a>t

Instruction: t103178483a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	103178508	-26	103178482	0.9	0.9	0.0	1.0	100	-1.7	-1.7	0.0
No Change	103178506	-24	103178482	4.5	4.5	0.0	1.0	100	-1.0	-1.0	0.0
No Change	103178490	-8	103178482	1.0	1.0	0.0	1.0	100	-1.7	-1.7	0.0
Decreased	103178482	0	103178482	10.8	3.4	-7.4	-171.7	0.5	0.4	-1.2	-1.6
No Change	103178438	44	103178482	7.2	7.2	0.0	1.0	100	-0.4	-0.4	0.0
No Change	103178431	51	103178482	7.0	7.0	0.0	1.0	100	-0.4	-0.4	0.0
increased	103178476	6	103178482	-1.5	0.4	2.0	1.3	134.0	-2.3	-1.8	0.4
Sites found for donor
No Change	103178453	29	103178482	0.1	0.1	0.0	1.0	100	-2.4	-2.4	0.0

IVS8nt1g>a

Instruction: c103178411t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	103178438	-27	103178411	7.2	7.2	0.0	1.0	100	-0.4	-0.4	0.0
No Change	103178431	-20	103178411	7.0	7.0	0.0	1.0	100	-0.4	-0.4	0.0
No Change	103178421	-10	103178411	2.5	2.5	0.0	1.0	100	-1.4	-1.4	0.0
Decreased	103178412	-1	103178411	9.4	8.4	-1.0	-1.9	51.5	0.1	-0.1	-0.2
Increased	103178407	4	103178411	1.4	1.7	0.3	1.2	123.3	-1.6	-1.6	0.1
No Change	103178384	27	103178411	5.1	5.1	0.0	1.0	100	-0.8	-0.8	0.0
No Change	103178378	33	103178411	8.4	8.4	0.0	1.0	100	-0.1	-0.1	0.0
Sites found for donor
No Change	103178453	-42	103178411	0.1	0.1	0.0	1.0	100	-2.4	-2.4	0.0
No Change	103178406	5	103178411	0.5	0.5	0.0	1.0	100	-2.3	-2.3	0.0
No Change	103178377	34	103178411	3.6	3.6	0.0	1.0	100	-1.3	-1.3	0.0
Decreased	103178411	0	103178411	11.5	-1.3	-12.8	-2922.7	NA	1.1	-2.8	-3.9

IVS8nt-5t>g

Instruction: a103173681c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	103173677	0	103173677	10.0	6.9	-3.1	-8.9	11.2	0.3	-0.4	-0.7
Decreased	103173683	-6	103173677	0.3	-0.2	-0.5	-1.2	NA	-1.9	-2.0	-0.1
Sites found for donor
No Change	103173676	1	103173677	1.4	1.4	0.0	1.0	100	-2.0	-2.0	0.0
No Change	103173654	23	103173677	0.2	0.2	0.0	1.0	100	-2.4	-2.4	0.0

IVS8nt-7a>g

Instruction: t103173683c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	103173711	-34	103173677	6.4	6.4	0.0	1.0	100	-0.5	-0.5	0.0
Increased	103173683	-6	103173677	0.3	7.9	7.6	191.1	19111.1	-1.9	-0.2	1.7
Decreased	103173677	0	103173677	10.0	10.0	-0.1	-1.0	95.7	0.3	0.2	-0.0
Sites found for donor
No Change	103173676	1	103173677	1.4	1.4	0.0	1.0	100	-2.0	-2.0	0.0
No Change	103173654	23	103173677	0.2	0.2	0.0	1.0	100	-2.4	-2.4	0.0

IVS9nt6t>a

Instruction: a103173614t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	103173600	19	103173619	3.5	1.5	-2.0	-3.9	25.5	-1.2	-1.6	-0.4
Decreased	103173599	20	103173619	3.1	1.5	-1.6	-2.9	34.1	-1.3	-1.6	-0.3
No Change	103173564	55	103173619	2.0	2.0	0.0	1.0	100	-1.5	-1.5	0.0
Sites found for donor
No Change	103173654	-35	103173619	0.2	0.2	0.0	1.0	100	-2.4	-2.4	0.0
Decreased	103173619	0	103173619	7.3	5.7	-1.6	-3.0	33.2	-0.2	-0.7	-0.5
No Change	103173598	21	103173619	2.8	2.8	0.0	1.0	100	-1.6	-1.6	0.0
No Change	103173591	28	103173619	2.2	2.2	0.0	1.0	100	-1.8	-1.8	0.0

IVS9nt-2a>c

Instruction: t103171158g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	103171175	-18	103171157	3.0	3.0	0.0	1.0	100	-1.3	-1.3	0.0
Decreased	103171157	0	103171157	9.6	2.2	-7.4	-171.7	0.5	0.2	-1.5	-1.6
Increased	103171149	8	103171157	1.9	3.9	2.0	4.1	407.6	-1.5	-1.1	0.4
Increased	103171136	21	103171157	0.2	0.7	0.5	1.4	141.7	-1.9	-1.8	0.1
Sites found for donor
No Change	103171186	-29	103171157	1.8	1.8	0.0	1.0	100	-1.9	-1.9	0.0
No Change	103171116	41	103171157	0.2	0.2	0.0	1.0	100	-2.4	-2.4	0.0

IVS9nt-5t>a

Instruction: a103171161t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	103171175	-18	103171157	3.0	3.0	0.0	1.0	100	-1.3	-1.3	0.0
Decreased	103171157	0	103171157	9.6	6.7	-2.8	-7.2	13.8	0.2	-0.5	-0.6
Decreased	103171149	8	103171157	1.9	-0.6	-2.5	-3.7	NA	-1.5	-2.1	-0.5
Decreased	103171136	21	103171157	0.2	-0.1	-0.3	-1.2	NA	-1.9	-2.0	-0.1
Sites found for donor
No Change	103171186	-29	103171157	1.8	1.8	0.0	1.0	100	-1.9	-1.9	0.0
No Change	103171116	41	103171157	0.2	0.2	0.0	1.0	100	-2.4	-2.4	0.0

IVS10nt1g>a

Instruction: c103171060t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	103171061	-1	103171060	7.6	6.7	-1.0	-1.9	51.5	-0.3	-0.5	-0.2
Decreased	103171046	14	103171060	3.8	3.5	-0.3	-1.2	81.8	-1.1	-1.2	-0.1
Sites found for donor
No Change	103171095	-35	103171060	2.2	2.2	0.0	1.0	100	-1.8	-1.8	0.0
No Change	103171071	-11	103171060	4.6	4.6	0.0	1.0	100	-1.0	-1.0	0.0
No Change	103171024	36	103171060	1.8	1.8	0.0	1.0	100	-1.9	-1.9	0.0
No Change	103171021	39	103171060	6.5	6.5	0.0	1.0	100	-0.5	-0.5	0.0
No Change	103171017	43	103171060	1.0	1.0	0.0	1.0	100	-2.1	-2.1	0.0
Decreased	103171060	0	103171060	7.8	-5.0	-12.8	-228.6	NA	-0.1	-3.9	-3.9

IVS10nt3a>g

Instruction: t103171058c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	103171061	-1	103171060	7.6	7.6	0.0	1.0	100	-0.3	-0.3	0.0
Increased	103171046	14	103171060	3.8	4.3	0.5	1.4	142.6	-1.1	-1.0	0.1
Sites found for donor
No Change	103171095	-35	103171060	2.2	2.2	0.0	1.0	100	-1.8	-1.8	0.0
No Change	103171071	-11	103171060	4.6	4.6	0.0	1.0	100	-1.0	-1.0	0.0
Decreased	103171060	0	103171060	7.8	7.4	-0.4	-1.3	75.7	-0.1	-0.2	-0.1
No Change	103171024	36	103171060	1.8	1.8	0.0	1.0	100	-1.9	-1.9	0.0
No Change	103171021	39	103171060	6.5	6.5	0.0	1.0	100	-0.5	-0.5	0.0
No Change	103171017	43	103171060	1.0	1.0	0.0	1.0	100	-2.1	-2.1	0.0

IVS10nt-11g>a

Instruction: c103170515t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	103170535	-30	103170505	1.2	1.2	0.0	1.0	100	-1.7	-1.7	0.0
Decreased	103170505	0	103170505	5.2	4.8	-0.4	-1.4	73.8	-0.8	-0.9	-0.1
Increased	103170492	13	103170505	1.8	2.2	0.3	1.2	124.0	-1.5	-1.5	0.1
No Change	103170466	39	103170505	2.1	2.1	0.0	1.0	100	-1.5	-1.5	0.0
increased	103170514	-9	103170505	-5.5	2.7	8.2	6.4	636.3	-3.1	-1.4	1.8
Sites found for donor
No Change	103170535	-30	103170505	1.6	1.6	0.0	1.0	100	-2.0	-2.0	0.0

IVS10nt-3c>t

Instruction: g103170507a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	103170535	-30	103170505	1.2	1.2	0.0	1.0	100	-1.7	-1.7	0.0
Decreased	103170505	0	103170505	5.2	3.6	-1.7	-3.2	31.6	-0.8	-1.2	-0.4
Increased	103170492	13	103170505	1.8	2.1	0.2	1.2	116.1	-1.5	-1.5	0.0
No Change	103170466	39	103170505	2.1	2.1	0.0	1.0	100	-1.5	-1.5	0.0
No Change	103170460	45	103170505	0.4	0.4	0.0	1.0	100	-1.8	-1.8	0.0
Sites found for donor
No Change	103170535	-30	103170505	1.6	1.6	0.0	1.0	100	-2.0	-2.0	0.0

IVS11nt1g>a

Instruction: c103170370t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor
Decreased	103170375	-5	103170370	7.8	7.4	-0.4	-1.3	77.5	-0.1	-0.2	-0.1
No Change	103170365	5	103170370	3.5	3.5	0.0	1.0	100	-1.4	-1.4	0.0
No Change	103170362	8	103170370	3.5	3.5	0.0	1.0	100	-1.4	-1.4	0.0
No Change	103170353	17	103170370	10.5	10.5	0.0	1.0	100	0.8	0.8	0.0
Decreased	103170370	0	103170370	10.4	-2.4	-12.8	-1372.3	NA	0.7	-3.2	-3.9

IVS11nt1g>c

Instruction: c103170370g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor
Decreased	103170375	-5	103170370	7.8	7.6	-0.2	-1.1	87.3	-0.1	-0.1	-0.1
Decreased	103170370	0	103170370	10.4	0.6	-9.8	-894.5	0.1	0.7	-2.2	-3.0
No Change	103170365	5	103170370	3.5	3.5	0.0	1.0	100	-1.4	-1.4	0.0
No Change	103170362	8	103170370	3.5	3.5	0.0	1.0	100	-1.4	-1.4	0.0
No Change	103170353	17	103170370	10.5	10.5	0.0	1.0	100	0.8	0.8	0.0

IVS11nt20g>c

Instruction: c103170351g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor
No Change	103170375	-5	103170370	7.8	7.8	0.0	1.0	100	-0.1	-0.1	0.0
No Change	103170370	0	103170370	10.4	10.4	0.0	1.0	100	0.7	0.7	0.0
No Change	103170365	5	103170370	3.5	3.5	0.0	1.0	100	-1.4	-1.4	0.0
No Change	103170362	8	103170370	3.5	3.5	0.0	1.0	100	-1.4	-1.4	0.0
Decreased	103170353	17	103170370	10.5	6.1	-4.4	-21.1	4.7	0.8	-0.6	-1.3
No Change	103170321	49	103170370	1.4	1.4	0.0	1.0	100	-2.0	-2.0	0.0
No Change	103170308	62	103170370	3.2	3.2	0.0	1.0	100	-1.5	-1.5	0.0
No Change	103170304	66	103170370	2.4	2.4	0.0	1.0	100	-1.7	-1.7	0.0