All Mutations grouped

Gene:	LIS1
mRNA Accession:	L13386
Chromosome:	chr 17
Sequence Walker

92T>C

Instruction: t2519535c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2519580	19	2519561	0.7	0.7	0.0	1.0	100	-1.8	-1.8	0.0
No Change	2519587	26	2519561	3.1	3.1	0.0	1.0	100	-1.3	-1.3	0.0
Sites found for donor
No Change	2519561	0	2519561	5.8	5.8	0.0	1.0	100	-0.7	-0.7	0.0

446A>G

Instruction: a2524313g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	2524329	63	2524266	0.7	0.8	0.0	1.0	103.1	-1.8	-1.8	0.0
No Change	2524349	83	2524266	3.5	3.5	0.0	1.0	100	-1.2	-1.2	0.0
Sites found for donor
No Change	2524267	1	2524266	8.4	8.4	0.0	1.0	100	0.1	0.1	0.0
No Change	2524269	3	2524266	0.9	0.9	0.0	1.0	100	-2.2	-2.2	0.0
No Change	2524352	86	2524266	0.1	0.1	0.0	1.0	100	-2.4	-2.4	0.0

484G>A

Instruction: g2524351a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2524329	-107	2524436	0.7	0.7	0.0	1.0	100	-1.8	-1.8	0.0
Increased	2524349	-87	2524436	3.5	3.6	0.0	1.0	103.1	-1.2	-1.2	0.0
No Change	2524378	-58	2524436	11.8	11.8	0.0	1.0	100	0.6	0.6	0.0
increased	2524352	-84	2524436	-6.3	1.9	8.2	3.6	364.3	-3.3	-1.5	1.8
Sites found for donor
Decreased	2524352	-84	2524436	0.1	-2.9	-3.1	-1.1	NA	-2.4	-3.3	-0.9

499T>C

Instruction: t2524366c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2524349	-87	2524436	3.5	3.5	0.0	1.0	100	-1.2	-1.2	0.0
Decreased	2524378	-58	2524436	11.8	11.4	-0.4	-1.3	75.9	0.6	0.6	-0.1
No Change	2524407	-29	2524436	2.6	2.6	0.0	1.0	100	-1.4	-1.4	0.0
Sites found for donor
No Change	2524352	-84	2524436	0.1	0.1	0.0	1.0	100	-2.4	-2.4	0.0

949G>C

Instruction: g2530657c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	2530655	47	2530608	4.4	4.0	-0.4	-1.3	74.5	-1.0	-1.1	-0.1
Decreased	2530657	49	2530608	0.9	-6.4	-7.3	-1.8	NA	-1.8	-3.3	-1.6
Sites found for donor
No Change	2530619	11	2530608	1.0	1.0	0.0	1.0	100	-2.1	-2.1	0.0
No Change	2530622	14	2530608	4.3	4.3	0.0	1.0	100	-1.1	-1.1	0.0
No Change	2530674	66	2530608	3.2	3.2	0.0	1.0	100	-1.5	-1.5	0.0
No Change	2530681	73	2530608	3.5	3.5	0.0	1.0	100	-1.4	-1.4	0.0
No Change	2530691	83	2530608	0.4	0.4	0.0	1.0	100	-2.3	-2.3	0.0
No Change	2530695	87	2530608	1.5	1.5	0.0	1.0	100	-2.0	-2.0	0.0

265C>T

Instruction: c2521168t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2521164	69	2521095	0.3	0.3	0.0	1.0	100	-1.9	-1.9	0.0
No Change	2521201	106	2521095	3.2	3.2	0.0	1.0	100	-1.2	-1.2	0.0
Sites found for donor
No Change	2521143	48	2521095	0.5	0.5	0.0	1.0	100	-2.3	-2.3	0.0
No Change	2521148	53	2521095	4.6	4.6	0.0	1.0	100	-1.0	-1.0	0.0
No Change	2521160	65	2521095	2.6	2.6	0.0	1.0	100	-1.6	-1.6	0.0

430C>T

Instruction: c2524297t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2524329	63	2524266	0.7	0.7	0.0	1.0	100	-1.8	-1.8	0.0
No Change	2524349	83	2524266	3.5	3.5	0.0	1.0	100	-1.2	-1.2	0.0
Sites found for donor
No Change	2524267	1	2524266	8.4	8.4	0.0	1.0	100	0.1	0.1	0.0
No Change	2524269	3	2524266	0.9	0.9	0.0	1.0	100	-2.2	-2.2	0.0

817C>T

Instruction: c2528309t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2528351	-42	2528393	4.2	4.2	0.0	1.0	100	-1.0	-1.0	0.0
Sites found for donor
No Change	2528264	-129	2528393	4.2	4.2	0.0	1.0	100	-1.2	-1.2	0.0
No Change	2528270	-123	2528393	3.2	3.2	0.0	1.0	100	-1.5	-1.5	0.0
No Change	2528291	-102	2528393	0.3	0.3	0.0	1.0	100	-2.4	-2.4	0.0
No Change	2528295	-98	2528393	0.4	0.4	0.0	1.0	100	-2.3	-2.3	0.0
No Change	2528324	-69	2528393	1.3	1.3	0.0	1.0	100	-2.0	-2.0	0.0
No Change	2528327	-66	2528393	1.2	1.2	0.0	1.0	100	-2.1	-2.1	0.0

866C>G

Instruction: c2528358g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2528351	-42	2528393	4.2	4.2	0.0	1.0	100	-1.0	-1.0	0.0
Decreased	2528378	-15	2528393	5.6	4.6	-1.0	-2.0	49.2	-0.7	-0.9	-0.2
No Change	2528384	-9	2528393	4.7	4.7	0.0	1.0	100	-0.9	-0.9	0.0
Decreased	2528375	-18	2528393	0.2	-1.1	-1.3	-1.1	NA	-1.9	-2.2	-0.3
Sites found for donor
No Change	2528324	-69	2528393	1.3	1.3	0.0	1.0	100	-2.0	-2.0	0.0
No Change	2528327	-66	2528393	1.2	1.2	0.0	1.0	100	-2.1	-2.1	0.0
No Change	2528393	0	2528393	2.8	2.8	0.0	1.0	100	-1.6	-1.6	0.0
No Change	2528398	5	2528393	0.6	0.6	0.0	1.0	100	-2.2	-2.2	0.0

154-155insA

Instruction: i2519965,2519966a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2519941	-178	2520119	2.3	2.3	0.0	1.0	100	-1.4	-1.4	0.0
No Change	2519959	-160	2520119	1.7	1.7	0.0	1.0	100	-1.6	-1.6	0.0
Decreased	2519969	-150	2520119	2.8	2.3	-0.5	-1.4	69.8	-1.3	-1.4	-0.1
Decreased	2519983	-136	2520119	2.6	2.0	-0.6	-1.5	65.6	-1.4	-1.5	-0.1
Decreased	2519967	-152	2520119	0.3	0.3	0.0	1.0	103.1	-1.9	-1.9	0.0
increased	2519966	-153	2520119	-7.5	0.3	7.8	1.3	125.3	-3.6	-1.9	1.7
Sites found for donor
No Change	2519942	-177	2520119	6.8	6.8	0.0	1.0	100	-0.4	-0.4	0.0
No Change	2519969	-150	2520119	1.3	1.3	0.0	1.0	100	-2.0	-2.0	0.0
No Change	2519984	-135	2520119	10.7	10.7	0.0	1.0	100	0.8	0.8	0.0

162-163insA

Instruction: i2519957,2519958a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2519934	-185	2520119	3.0	3.0	0.0	1.0	100	-1.3	-1.3	0.0
No Change	2519941	-178	2520119	2.3	2.3	0.0	1.0	100	-1.4	-1.4	0.0
Decreased	2519959	-160	2520119	1.7	1.6	-0.1	-1.1	91.7	-1.6	-1.6	-0.0
Decreased	2519969	-150	2520119	2.8	2.0	-0.9	-1.8	54.6	-1.3	-1.5	-0.2
No Change	2519983	-136	2520119	2.6	2.6	0.0	1.0	100	-1.4	-1.4	0.0
Decreased	2519967	-152	2520119	0.3	-8.9	-9.1	-1.2	NA	-1.9	-3.9	-2.0
Sites found for donor
No Change	2519908	-211	2520119	0.7	0.7	0.0	1.0	100	-2.2	-2.2	0.0
No Change	2519942	-177	2520119	6.8	6.8	0.0	1.0	100	-0.4	-0.4	0.0
No Change	2519969	-150	2520119	1.3	1.3	0.0	1.0	100	-2.0	-2.0	0.0
No Change	2519984	-135	2520119	10.7	10.7	0.0	1.0	100	0.8	0.8	0.0

162delA

Instruction: d2520164,2520164 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor
No Change	2520140	-55	2520195	4.5	4.5	0.0	1.0	100	-1.1	-1.1	0.0
No Change	2520195	0	2520195	8.6	8.6	0.0	1.0	100	0.2	0.2	0.0

166delA

Instruction: d2520168,2520168 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2520217	22	2520195	0.8	0.8	0.0	1.0	100	-1.8	-1.8	0.0
No Change	2520219	24	2520195	0.0	0.0	0.0	1.0	100	-1.9	-1.9	0.0
Sites found for donor
No Change	2520140	-55	2520195	4.5	4.5	0.0	1.0	100	-1.1	-1.1	0.0
No Change	2520195	0	2520195	8.6	8.6	0.0	1.0	100	0.2	0.2	0.0

703-704delGA

Instruction: d2527460,2527461 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2527434	-729	2528163	1.7	1.7	0.0	1.0	100	-1.6	-1.6	0.0
No Change	2527495	-668	2528163	2.5	2.5	0.0	1.0	100	-1.4	-1.4	0.0
Sites found for donor
No Change	2527420	-743	2528163	4.9	4.9	0.0	1.0	100	-1.0	-1.0	0.0
No Change	2527431	-732	2528163	2.3	2.3	0.0	1.0	100	-1.7	-1.7	0.0
No Change	2527447	-716	2528163	0.9	0.9	0.0	1.0	100	-2.2	-2.2	0.0
No Change	2527449	-714	2528163	3.5	3.5	0.0	1.0	100	-1.4	-1.4	0.0
No Change	2527473	-690	2528163	2.4	2.4	0.0	1.0	100	-1.7	-1.7	0.0
No Change	2527486	-677	2528163	1.8	1.8	0.0	1.0	100	-1.9	-1.9	0.0

771-772delTG

Instruction: d2527392,2527393 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2527419	-744	2528163	11.8	11.8	0.0	1.0	100	0.6	0.6	0.0
No Change	2527434	-729	2528163	1.7	1.7	0.0	1.0	100	-1.6	-1.6	0.0
Sites found for donor
No Change	2527348	-815	2528163	5.9	5.9	0.0	1.0	100	-0.6	-0.6	0.0
No Change	2527353	-810	2528163	2.6	2.6	0.0	1.0	100	-1.6	-1.6	0.0
No Change	2527420	-743	2528163	4.9	4.9	0.0	1.0	100	-1.0	-1.0	0.0
No Change	2527431	-732	2528163	2.3	2.3	0.0	1.0	100	-1.7	-1.7	0.0
Decreased	2527386	-777	2528163	0.8	-0.1	-0.9	-1.7	NA	-2.2	-2.5	-0.3
increased	2527391	-772	2528163	-12.9	0.3	13.2	1.2	123.8	-6.4	-2.3	4.0

805delA

Instruction: d2528297,2528297 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor
No Change	2528264	-129	2528393	4.2	4.2	0.0	1.0	100	-1.2	-1.2	0.0
No Change	2528270	-123	2528393	3.2	3.2	0.0	1.0	100	-1.5	-1.5	0.0
No Change	2528291	-102	2528393	0.3	0.3	0.0	1.0	100	-2.4	-2.4	0.0
No Change	2528324	-69	2528393	1.3	1.3	0.0	1.0	100	-2.0	-2.0	0.0
No Change	2528327	-66	2528393	1.2	1.2	0.0	1.0	100	-2.1	-2.1	0.0
Decreased	2528295	-98	2528393	0.4	-2.7	-3.1	-1.3	NA	-2.3	-3.3	-0.9

881-882delCT

Instruction: d2527282,2527283 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2527332	-831	2528163	1.7	1.7	0.0	1.0	100	-1.6	-1.6	0.0
Sites found for donor
No Change	2527233	-930	2528163	1.8	1.8	0.0	1.0	100	-1.9	-1.9	0.0

903-904insT

Instruction: i2529705,2529706t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2529733	-875	2530608	5.6	5.6	0.0	1.0	100	-0.7	-0.7	0.0
No Change	2529755	-853	2530608	4.8	4.8	0.0	1.0	100	-0.9	-0.9	0.0
No Change	2529756	-852	2530608	3.4	3.4	0.0	1.0	100	-1.2	-1.2	0.0
No Change	2529757	-851	2530608	2.6	2.6	0.0	1.0	100	-1.4	-1.4	0.0
Sites found for donor
No Change	2529665	-943	2530608	0.6	0.6	0.0	1.0	100	-2.3	-2.3	0.0
No Change	2529675	-933	2530608	1.3	1.3	0.0	1.0	100	-2.0	-2.0	0.0

1018-1019insT

Instruction: i2533249,2533250t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	2533256	-1011	2534267	2.6	3.6	1.1	2.1	207.1	-1.4	-1.1	0.2
Increased	2533268	-999	2534267	1.8	2.4	0.5	1.5	146.2	-1.5	-1.4	0.1
increased	2533260	-1007	2534267	-0.7	0.6	1.3	1.5	153.9	-2.1	-1.8	0.3
Sites found for donor
No Change	2533207	-1060	2534267	1.0	1.0	0.0	1.0	100	-2.1	-2.1	0.0
No Change	2533240	-1027	2534267	1.3	1.3	0.0	1.0	100	-2.0	-2.0	0.0
No Change	2533257	-1010	2534267	5.5	5.5	0.0	1.0	100	-0.8	-0.8	0.0
No Change	2533288	-979	2534267	6.8	6.8	0.0	1.0	100	-0.4	-0.4	0.0
No Change	2533292	-975	2534267	1.9	1.9	0.0	1.0	100	-1.9	-1.9	0.0

1050-1051insG

Instruction: i2533217,2533218g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2533206	-1061	2534267	0.1	0.1	0.0	1.0	100	-1.9	-1.9	0.0
No Change	2533212	-1055	2534267	8.9	8.9	0.0	1.0	100	0.0	0.0	0.0
No Change	2533256	-1011	2534267	2.6	2.6	0.0	1.0	100	-1.4	-1.4	0.0
No Change	2533268	-999	2534267	1.8	1.8	0.0	1.0	100	-1.5	-1.5	0.0
Sites found for donor
increased	newly inserted = 2533218	-1049	2534267	0.0	3.1	3.1	8.4	842.3	0.0	-1.5	-1.5
No Change	2533207	-1060	2534267	1.0	1.0	0.0	1.0	100	-2.1	-2.1	0.0
No Change	2533240	-1027	2534267	1.3	1.3	0.0	1.0	100	-2.0	-2.0	0.0
No Change	2533257	-1010	2534267	5.5	5.5	0.0	1.0	100	-0.8	-0.8	0.0

c.569-10T>C

Instruction: t2526749c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	2526758	0	2526758	5.9	5.3	-0.6	-1.5	66.7	-0.6	-0.8	-0.1
No Change	2526782	24	2526758	3.0	3.0	0.0	1.0	100	-1.3	-1.3	0.0
No Change	2526785	27	2526758	3.6	3.6	0.0	1.0	100	-1.2	-1.2	0.0
Sites found for donor
No Change	2526717	-41	2526758	0.0	0.0	0.0	1.0	100	-2.4	-2.4	0.0
No Change	2526720	-38	2526758	2.3	2.3	0.0	1.0	100	-1.7	-1.7	0.0
Increased	2526746	-12	2526758	0.1	0.1	0.0	1.0	102.0	-2.4	-2.4	0.0

c.900+1G>A

Instruction: g2528393a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2528375	-18	2528393	0.2	0.2	0.0	1.0	100	-1.9	-1.9	0.0
No Change	2528378	-15	2528393	5.6	5.6	0.0	1.0	100	-0.7	-0.7	0.0
No Change	2528384	-9	2528393	4.7	4.7	0.0	1.0	100	-0.9	-0.9	0.0
No Change	2528430	37	2528393	1.6	1.6	0.0	1.0	100	-1.6	-1.6	0.0
No Change	2528440	47	2528393	0.8	0.8	0.0	1.0	100	-1.8	-1.8	0.0
Sites found for donor
No Change	2528398	5	2528393	0.6	0.6	0.0	1.0	100	-2.2	-2.2	0.0
Decreased	2528393	0	2528393	2.8	-10.0	-12.8	-7.1	NA	-1.6	-5.5	-3.9

c.1002+1G>A

Instruction: g2530711a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2530744	33	2530711	2.7	2.7	0.0	1.0	100	-1.3	-1.3	0.0
No Change	2530750	39	2530711	4.3	4.3	0.0	1.0	100	-1.0	-1.0	0.0
No Change	2530752	41	2530711	3.6	3.6	0.0	1.0	100	-1.1	-1.1	0.0
No Change	2530759	48	2530711	1.3	1.3	0.0	1.0	100	-1.6	-1.6	0.0
Sites found for donor
No Change	2530674	-37	2530711	3.2	3.2	0.0	1.0	100	-1.5	-1.5	0.0
No Change	2530681	-30	2530711	3.5	3.5	0.0	1.0	100	-1.4	-1.4	0.0
No Change	2530691	-20	2530711	0.4	0.4	0.0	1.0	100	-2.3	-2.3	0.0
No Change	2530695	-16	2530711	1.5	1.5	0.0	1.0	100	-2.0	-2.0	0.0
Decreased	2530711	0	2530711	6.0	-6.8	-12.8	-65.6	NA	-0.6	-4.5	-3.9

c.1002+5G>A

Instruction: g2530715a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2530744	33	2530711	2.7	2.7	0.0	1.0	100	-1.3	-1.3	0.0
No Change	2530750	39	2530711	4.3	4.3	0.0	1.0	100	-1.0	-1.0	0.0
No Change	2530752	41	2530711	3.6	3.6	0.0	1.0	100	-1.1	-1.1	0.0
No Change	2530759	48	2530711	1.3	1.3	0.0	1.0	100	-1.6	-1.6	0.0
No Change	2530766	55	2530711	1.7	1.7	0.0	1.0	100	-1.6	-1.6	0.0
No Change	2530767	56	2530711	1.5	1.5	0.0	1.0	100	-1.6	-1.6	0.0
Sites found for donor
No Change	2530674	-37	2530711	3.2	3.2	0.0	1.0	100	-1.5	-1.5	0.0
No Change	2530681	-30	2530711	3.5	3.5	0.0	1.0	100	-1.4	-1.4	0.0
No Change	2530691	-20	2530711	0.4	0.4	0.0	1.0	100	-2.3	-2.3	0.0
No Change	2530695	-16	2530711	1.5	1.5	0.0	1.0	100	-2.0	-2.0	0.0
Decreased	2530711	0	2530711	6.0	2.5	-3.5	-11.5	8.7	-0.6	-1.7	-1.1

c.1159+3insCA

Instruction: i2492395,2492396ca ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2492387	-38	2492425	1.8	1.8	0.0	1.0	100	-1.6	-1.6	0.0
Decreased	2492407	-18	2492425	1.8	0.9	-0.9	-1.8	54.7	-1.6	-1.7	-0.2
Sites found for donor
No Change	2492348	-77	2492425	0.0	0.0	0.0	1.0	100	-2.4	-2.4	0.0
No Change	2492425	0	2492425	6.7	6.7	0.0	1.0	100	-0.4	-0.4	0.0
Decreased	2492396	-29	2492425	1.3	-12.6	-13.9	-2.5	NA	-2.0	-6.3	-4.2

c.568+27T>C

Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Unprocessed due to the following error. c.568+27T>C the old base at 2524462 is NOT t! It is c.

687A>T

Instruction: a2528179t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2528163	0	2528163	3.5	3.5	0.0	1.0	100	-1.2	-1.2	0.0
Increased	2528186	23	2528163	0.6	2.5	2.0	3.9	391.8	-1.8	-1.4	0.4
Sites found for donor
No Change	2528140	-23	2528163	6.4	6.4	0.0	1.0	100	-0.5	-0.5	0.0
No Change	2528169	6	2528163	2.2	2.2	0.0	1.0	100	-1.8	-1.8	0.0
No Change	2528171	8	2528163	0.4	0.4	0.0	1.0	100	-2.3	-2.3	0.0
No Change	2528201	38	2528163	5.8	5.8	0.0	1.0	100	-0.7	-0.7	0.0
No Change	2528205	42	2528163	2.2	2.2	0.0	1.0	100	-1.8	-1.8	0.0
No Change	2528210	47	2528163	6.0	6.0	0.0	1.0	100	-0.6	-0.6	0.0

1188C>T

Instruction: c2535861t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	2535832	0	2535832	14.4	14.4	0.0	1.0	100	1.2	1.2	0.0
No Change	2535840	8	2535832	4.6	4.6	0.0	1.0	100	-0.9	-0.9	0.0
No Change	2535842	10	2535832	4.2	4.2	0.0	1.0	100	-1.0	-1.0	0.0
No Change	2535843	11	2535832	3.9	3.9	0.0	1.0	100	-1.1	-1.1	0.0
Increased	2535869	37	2535832	3.5	3.8	0.3	1.2	124.6	-1.2	-1.1	0.1
Increased	2535874	42	2535832	1.9	2.4	0.4	1.3	134.9	-1.5	-1.4	0.1
Sites found for donor
No Change	2535883	51	2535832	2.8	2.8	0.0	1.0	100	-1.6	-1.6	0.0
No Change	2535889	57	2535832	5.2	5.2	0.0	1.0	100	-0.9	-0.9	0.0
No Change	2535891	59	2535832	2.8	2.8	0.0	1.0	100	-1.6	-1.6	0.0

1236T>G

Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Unprocessed due to the following error. 1236T>G the old base at 2535909 is NOT t! It is g.

1250C>T

Instruction: c2535923t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor