All Mutations grouped

Gene:	COL1A1
mRNA Accession:	Z74615
Chromosome:	chr 17
Sequence Walker

IVS3+1G>C

Instruction: c48618995g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	48618966	29	48618995	0.0	0.0	0.0	1.0	100	-1.9	-1.9	0.0
No Change	48618944	51	48618995	4.3	4.3	0.0	1.0	100	-1.0	-1.0	0.0
Sites found for donor
No Change	48618957	38	48618995	2.1	2.1	0.0	1.0	100	-1.8	-1.8	0.0
Decreased	48618995	0	48618995	5.7	-4.1	-9.8	-52.2	NA	-0.7	-3.7	-3.0

c.333G>T;.c333+1G>C

Instruction: c48619277a.c48619192g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	48619193	-1	48619192	4.9	3.0	-1.9	-3.8	26.5	-0.9	-1.3	-0.4
Sites found for donor
No Change	48619294	-102	48619192	1.3	1.3	0.0	1.0	100	-2.0	-2.0	0.0
No Change	48619289	-97	48619192	3.4	3.4	0.0	1.0	100	-1.4	-1.4	0.0
No Change	48619284	-92	48619192	0.5	0.5	0.0	1.0	100	-2.3	-2.3	0.0
Decreased	48619274	-82	48619192	1.3	0.8	-0.4	-1.4	73.7	-2.1	-2.2	-0.1
No Change	48619267	-75	48619192	0.2	0.2	0.0	1.0	100	-2.4	-2.4	0.0
No Change	48619225	-33	48619192	2.8	2.8	0.0	1.0	100	-1.6	-1.6	0.0
Decreased	48619192	0	48619192	7.8	-2.0	-9.8	-227.8	NA	-0.1	-3.0	-3.0

IVS5-2A>G

Instruction: t48617946c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	48617965	-20	48617945	0.6	0.6	0.0	1.0	100	-1.8	-1.8	0.0
No Change	48617955	-10	48617945	0.2	0.2	0.0	1.0	100	-1.9	-1.9	0.0
Decreased	48617945	0	48617945	10.9	2.7	-8.2	-286.2	0.3	0.4	-1.3	-1.8
Increased	48617930	15	48617945	7.4	7.4	0.0	1.0	103.1	-0.3	-0.3	0.0
increased	48617946	-1	48617945	-3.1	4.5	7.6	22.2	2215.5	-2.6	-1.0	1.7
Sites found for donor

IVS5-1G>A

Instruction: c48617945t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	48617965	-20	48617945	0.6	0.6	0.0	1.0	100	-1.8	-1.8	0.0
No Change	48617955	-10	48617945	0.2	0.2	0.0	1.0	100	-1.9	-1.9	0.0
Decreased	48617945	0	48617945	10.9	3.3	-7.6	-191.1	0.5	0.4	-1.2	-1.7
Decreased	48617930	15	48617945	7.4	7.1	-0.2	-1.2	85.8	-0.3	-0.4	-0.0
increased	48617943	2	48617945	-0.2	1.5	1.7	2.9	292.8	-2.0	-1.6	0.4
Sites found for donor

c.503G>A

Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Unprocessed due to the following error. c.503G>A the old base at 48618753 is NOT c! It is g.

IVS8+1G>C

Instruction: c48617388g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	48617370	18	48617388	5.6	6.4	0.8	1.8	179.6	-0.7	-0.5	0.2
No Change	48617351	37	48617388	1.3	1.3	0.0	1.0	100	-1.6	-1.6	0.0
No Change	48617343	45	48617388	3.1	3.1	0.0	1.0	100	-1.3	-1.3	0.0
Sites found for donor
No Change	48617414	-26	48617388	8.6	8.6	0.0	1.0	100	0.2	0.2	0.0
No Change	48617405	-17	48617388	1.1	1.1	0.0	1.0	100	-2.1	-2.1	0.0
Decreased	48617388	0	48617388	4.6	-5.2	-9.8	-24.9	NA	-1.0	-4.0	-3.0

IVS9-1G>T

Instruction: c48616674a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	48616674	0	48616674	14.2	5.5	-8.7	-430.0	0.2	1.2	-0.7	-1.9
Increased	48616673	1	48616674	2.7	3.4	0.7	1.7	166.6	-1.4	-1.2	0.2
Increased	48616667	7	48616674	0.2	2.1	2.0	3.9	391.8	-1.9	-1.5	0.4
increased	48616672	2	48616674	-0.3	4.0	4.3	16.2	1620.7	-2.0	-1.1	0.9
Sites found for donor
No Change	48616718	-44	48616674	1.8	1.8	0.0	1.0	100	-1.9	-1.9	0.0
No Change	48616715	-41	48616674	5.3	5.3	0.0	1.0	100	-0.8	-0.8	0.0
No Change	48616645	29	48616674	9.2	9.2	0.0	1.0	100	0.4	0.4	0.0
No Change	48616639	35	48616674	1.6	1.6	0.0	1.0	100	-1.9	-1.9	0.0

IVS11+3-+6delGAGT

Instruction: d48616444,48616447 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	48616425	24	48616449	0.1	0.5	0.3	1.3	125.1	-1.9	-1.8	0.1
No Change	48616416	33	48616449	0.7	0.7	0.0	1.0	100	-1.8	-1.8	0.0
No Change	48616409	40	48616449	2.2	2.2	0.0	1.0	100	-1.5	-1.5	0.0
Sites found for donor
Decreased	48616449	0	48616449	6.6	-10.7	-17.3	-98.2	NA	-0.4	-5.7	-5.3

IVS12+1G>A

Instruction: c48616056t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	48616057	-1	48616056	1.3	0.4	-1.0	-1.9	51.5	-1.6	-1.9	-0.2
No Change	48616016	40	48616056	6.9	6.9	0.0	1.0	100	-0.4	-0.4	0.0
No Change	48616014	42	48616056	1.1	1.1	0.0	1.0	100	-1.7	-1.7	0.0
Sites found for donor
No Change	48616100	-44	48616056	0.6	0.6	0.0	1.0	100	-2.2	-2.2	0.0
No Change	48616091	-35	48616056	1.4	1.4	0.0	1.0	100	-2.0	-2.0	0.0
Decreased	48616056	0	48616056	11.4	-1.4	-12.8	-2677.4	NA	1.0	-2.9	-3.9

IVS13-10T>A

Instruction: a48615817t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	48615821	-13	48615808	3.1	3.1	0.0	1.0	100	-1.3	-1.3	0.0
Decreased	48615808	0	48615808	8.4	5.8	-2.6	-6.1	16.3	-0.1	-0.7	-0.6
increased	48615816	-8	48615808	-0.3	7.1	7.4	140.1	14005.3	-2.0	-0.4	1.6
Sites found for donor
No Change	48615812	-4	48615808	0.5	0.5	0.0	1.0	100	-2.3	-2.3	0.0
No Change	48615788	20	48615808	9.0	9.0	0.0	1.0	100	0.3	0.3	0.0
increased	48615820	-12	48615808	-0.3	2.8	3.1	6.8	676.1	-2.5	-1.6	0.9

c.904-10T>A

Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Unprocessed due to the following error. c.904-10T>A the old base at 48616513 is NOT a! It is g.

IVS14+5G>A

Instruction: c48615749t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	48615700	53	48615753	0.7	0.7	0.0	1.0	100	-1.8	-1.8	0.0
Sites found for donor
No Change	48615788	-35	48615753	9.0	9.0	0.0	1.0	100	0.3	0.3	0.0
Decreased	48615753	0	48615753	6.2	2.7	-3.5	-11.5	8.7	-0.5	-1.6	-1.1

IVS15-33--44delCTGCCATCTCTT

Instruction: d48615661,48615672 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	48615700	-60	48615640	0.7	0.7	0.0	1.0	100	-1.8	-1.8	0.0
Decreased	48615643	-3	48615640	3.1	2.4	-0.7	-1.7	59.7	-1.3	-1.4	-0.2
Increased	48615640	0	48615640	12.8	14.0	1.2	2.4	236.5	0.9	1.1	0.3
Sites found for donor
No Change	48615638	2	48615640	1.9	1.9	0.0	1.0	100	-1.9	-1.9	0.0

IVS16-2A>G

Instruction: t48615107c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	48615112	-6	48615106	2.4	2.4	0.0	1.0	100	-1.4	-1.4	0.0
Decreased	48615106	0	48615106	11.4	3.3	-8.2	-286.2	0.3	0.6	-1.2	-1.8
No Change	48615069	37	48615106	0.6	0.6	0.0	1.0	100	-1.8	-1.8	0.0
No Change	48615061	45	48615106	0.8	0.8	0.0	1.0	100	-1.8	-1.8	0.0
increased	48615107	-1	48615106	-6.6	0.9	7.6	1.9	192.8	-3.4	-1.7	1.7
increased	48615099	7	48615106	-0.1	0.2	0.3	1.2	116.4	-2.0	-1.9	0.1
Sites found for donor
No Change	48615158	-52	48615106	2.3	2.3	0.0	1.0	100	-1.7	-1.7	0.0
No Change	48615153	-47	48615106	3.8	3.8	0.0	1.0	100	-1.3	-1.3	0.0
No Change	48615138	-32	48615106	2.8	2.8	0.0	1.0	100	-1.6	-1.6	0.0
Decreased	48615104	2	48615106	4.9	3.9	-1.0	-2.0	49.9	-0.9	-1.2	-0.3
No Change	48615059	47	48615106	5.8	5.8	0.0	1.0	100	-0.7	-0.7	0.0

IVS17+1G>C

Instruction: c48615006g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	48615024	-18	48615006	2.2	2.2	0.0	1.0	100	-1.5	-1.5	0.0
No Change	48615015	-9	48615006	0.6	0.6	0.0	1.0	100	-1.8	-1.8	0.0
Increased	48614988	18	48615006	2.6	3.5	0.8	1.8	179.6	-1.4	-1.2	0.2
No Change	48614966	40	48615006	0.4	0.4	0.0	1.0	100	-1.9	-1.9	0.0
No Change	48614960	46	48615006	9.9	9.9	0.0	1.0	100	0.2	0.2	0.0
No Change	48614958	48	48615006	2.8	2.8	0.0	1.0	100	-1.3	-1.3	0.0
increased	48615002	4	48615006	-2.0	0.5	2.5	1.4	140.9	-2.4	-1.8	0.6
Sites found for donor
No Change	48615057	-51	48615006	2.9	2.9	0.0	1.0	100	-1.6	-1.6	0.0
No Change	48615050	-44	48615006	7.4	7.4	0.0	1.0	100	-0.2	-0.2	0.0
No Change	48615023	-17	48615006	1.8	1.8	0.0	1.0	100	-1.9	-1.9	0.0
Decreased	48615006	0	48615006	6.6	-3.2	-9.8	-99.1	NA	-0.4	-3.4	-3.0

IVS18+1G>A

Instruction: c48614873t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	48614851	22	48614873	1.3	1.8	0.4	1.4	135.5	-1.6	-1.5	0.1
No Change	48614830	43	48614873	8.1	8.1	0.0	1.0	100	-0.2	-0.2	0.0
Decreased	48614858	15	48614873	0.1	-0.2	-0.2	-1.0	NA	-1.9	-2.0	-0.0
Sites found for donor
No Change	48614908	-35	48614873	2.0	2.0	0.0	1.0	100	-1.8	-1.8	0.0
No Change	48614890	-17	48614873	1.6	1.6	0.0	1.0	100	-1.9	-1.9	0.0
No Change	48614881	-8	48614873	3.6	3.6	0.0	1.0	100	-1.3	-1.3	0.0
Decreased	48614873	0	48614873	9.3	-3.5	-12.8	-613.6	NA	0.4	-3.5	-3.9

IVS18-1G>A

Instruction: c48614771t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	48614800	-29	48614771	0.9	0.9	0.0	1.0	100	-1.7	-1.7	0.0
No Change	48614795	-24	48614771	1.2	1.2	0.0	1.0	100	-1.7	-1.7	0.0
Increased	48614773	-2	48614771	2.2	2.2	0.0	1.0	103.1	-1.5	-1.5	0.0
Decreased	48614771	0	48614771	10.4	2.8	-7.6	-191.1	0.5	0.3	-1.3	-1.7
Increased	48614752	19	48614771	0.0	0.2	0.2	1.1	113.7	-1.9	-1.9	0.0
No Change	48614734	37	48614771	2.5	2.5	0.0	1.0	100	-1.4	-1.4	0.0
No Change	48614725	46	48614771	2.3	2.3	0.0	1.0	100	-1.4	-1.4	0.0
increased	48614770	1	48614771	-2.6	5.6	8.2	47.7	4770.3	-2.5	-0.7	1.8
Sites found for donor
Increased	48614769	2	48614771	1.3	3.6	2.3	4.9	489.0	-2.0	-1.4	0.7
No Change	48614760	11	48614771	2.2	2.2	0.0	1.0	100	-1.8	-1.8	0.0
No Change	48614751	20	48614771	1.6	1.6	0.0	1.0	100	-1.9	-1.9	0.0
No Change	48614733	38	48614771	2.2	2.2	0.0	1.0	100	-1.8	-1.8	0.0

IVS19+1G>A

Instruction: c48614671t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	48614681	-10	48614671	3.6	3.6	0.0	1.0	100	-1.1	-1.1	0.0
No Change	48614643	28	48614671	0.4	0.4	0.0	1.0	100	-1.8	-1.8	0.0
No Change	48614638	33	48614671	2.6	2.6	0.0	1.0	100	-1.4	-1.4	0.0
No Change	48614634	37	48614671	0.9	0.9	0.0	1.0	100	-1.8	-1.8	0.0
No Change	48614632	39	48614671	0.2	0.2	0.0	1.0	100	-1.9	-1.9	0.0
No Change	48614625	46	48614671	3.9	3.9	0.0	1.0	100	-1.1	-1.1	0.0
Sites found for donor
No Change	48614679	-8	48614671	5.1	5.1	0.0	1.0	100	-0.9	-0.9	0.0
No Change	48614625	46	48614671	2.8	2.8	0.0	1.0	100	-1.6	-1.6	0.0
Decreased	48614671	0	48614671	5.8	-7.0	-12.8	-57.3	NA	-0.7	-4.6	-3.9

IVS19+1G>C

Instruction: c48614671g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	48614681	-10	48614671	3.6	3.6	0.0	1.0	100	-1.1	-1.1	0.0
No Change	48614643	28	48614671	0.4	0.4	0.0	1.0	100	-1.8	-1.8	0.0
No Change	48614638	33	48614671	2.6	2.6	0.0	1.0	100	-1.4	-1.4	0.0
No Change	48614634	37	48614671	0.9	0.9	0.0	1.0	100	-1.8	-1.8	0.0
No Change	48614632	39	48614671	0.2	0.2	0.0	1.0	100	-1.9	-1.9	0.0
No Change	48614625	46	48614671	3.9	3.9	0.0	1.0	100	-1.1	-1.1	0.0
Sites found for donor
No Change	48614679	-8	48614671	5.1	5.1	0.0	1.0	100	-0.9	-0.9	0.0
No Change	48614625	46	48614671	2.8	2.8	0.0	1.0	100	-1.6	-1.6	0.0
Decreased	48614671	0	48614671	5.8	-4.0	-9.8	-57.3	NA	-0.7	-3.6	-3.0

c.1299+1G>C

Instruction: c48614873g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	48614858	15	48614873	0.1	1.2	1.1	2.2	216.5	-1.9	-1.7	0.2
Increased	48614851	22	48614873	1.3	2.3	0.9	1.9	192.0	-1.6	-1.4	0.2
No Change	48614830	43	48614873	8.1	8.1	0.0	1.0	100	-0.2	-0.2	0.0
Sites found for donor
No Change	48614908	-35	48614873	2.0	2.0	0.0	1.0	100	-1.8	-1.8	0.0
No Change	48614890	-17	48614873	1.6	1.6	0.0	1.0	100	-1.9	-1.9	0.0
No Change	48614881	-8	48614873	3.6	3.6	0.0	1.0	100	-1.3	-1.3	0.0
Decreased	48614873	0	48614873	9.3	-0.5	-9.8	-613.6	NA	0.4	-2.6	-3.0

IVS20-2A>G

Instruction: t48614270c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	48614297	-28	48614269	4.5	4.5	0.0	1.0	100	-1.0	-1.0	0.0
No Change	48614280	-11	48614269	1.2	1.2	0.0	1.0	100	-1.7	-1.7	0.0
No Change	48614279	-10	48614269	0.8	0.8	0.0	1.0	100	-1.8	-1.8	0.0
Decreased	48614269	0	48614269	12.7	4.5	-8.2	-286.2	0.3	0.8	-0.9	-1.8
Decreased	48614250	19	48614269	3.5	3.2	-0.3	-1.2	81.8	-1.2	-1.2	-0.1
No Change	48614232	37	48614269	0.4	0.4	0.0	1.0	100	-1.9	-1.9	0.0
No Change	48614229	40	48614269	0.5	0.5	0.0	1.0	100	-1.8	-1.8	0.0
increased	48614270	-1	48614269	-2.5	5.1	7.6	33.3	3333.6	-2.5	-0.8	1.7
Sites found for donor
No Change	48614262	7	48614269	0.7	0.7	0.0	1.0	100	-2.2	-2.2	0.0
No Change	48614258	11	48614269	0.2	0.2	0.0	1.0	100	-2.4	-2.4	0.0
No Change	48614231	38	48614269	1.2	1.2	0.0	1.0	100	-2.1	-2.1	0.0
No Change	48614222	47	48614269	3.8	3.8	0.0	1.0	100	-1.3	-1.3	0.0

IVS20+2T>C

Instruction: a48614485g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	48614459	27	48614486	9.9	9.9	0.0	1.0	100	0.2	0.2	0.0
No Change	48614454	32	48614486	7.0	7.0	0.0	1.0	100	-0.4	-0.4	0.0
No Change	48614439	47	48614486	5.1	5.1	0.0	1.0	100	-0.8	-0.8	0.0
Sites found for donor
No Change	48614530	-44	48614486	1.6	1.6	0.0	1.0	100	-1.9	-1.9	0.0
No Change	48614503	-17	48614486	1.6	1.6	0.0	1.0	100	-1.9	-1.9	0.0
No Change	48614494	-8	48614486	0.5	0.5	0.0	1.0	100	-2.3	-2.3	0.0
Decreased	48614486	0	48614486	7.2	-0.3	-7.5	-145.0	NA	-0.3	-2.5	-2.3

IVS19-12G>A

Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Unprocessed due to the following error. IVS19-12G>A the old base at 48614552 is NOT c! It is g.

IVS22-1G>T

Instruction: c48613888a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	48613892	-4	48613888	0.1	0.1	0.0	1.0	100	-1.9	-1.9	0.0
No Change	48613851	37	48613888	1.5	1.5	0.0	1.0	100	-1.6	-1.6	0.0
No Change	48613842	46	48613888	5.3	5.3	0.0	1.0	100	-0.8	-0.8	0.0
Decreased	48613888	0	48613888	7.0	-1.8	-8.7	-127.8	NA	-0.4	-2.3	-1.9
Sites found for donor
No Change	48613905	-17	48613888	2.5	2.5	0.0	1.0	100	-1.7	-1.7	0.0
No Change	48613877	11	48613888	5.7	5.7	0.0	1.0	100	-0.7	-0.7	0.0
No Change	48613871	17	48613888	1.4	1.4	0.0	1.0	100	-2.0	-2.0	0.0

IVS22+3A>G

Instruction: t48614010c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	48614033	-21	48614012	4.8	4.8	0.0	1.0	100	-0.9	-0.9	0.0
No Change	48614013	-1	48614012	0.8	0.8	0.0	1.0	100	-1.8	-1.8	0.0
Sites found for donor
No Change	48614056	-44	48614012	3.1	3.1	0.0	1.0	100	-1.5	-1.5	0.0
No Change	48614029	-17	48614012	1.6	1.6	0.0	1.0	100	-1.9	-1.9	0.0
Decreased	48614012	0	48614012	6.7	6.3	-0.4	-1.3	75.7	-0.4	-0.5	-0.1

IVS25-1G>A

Instruction: c48612488t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	48612490	-2	48612488	5.0	5.1	0.0	1.0	103.1	-0.8	-0.8	0.0
Decreased	48612488	0	48612488	13.8	6.3	-7.6	-191.1	0.5	1.1	-0.6	-1.7
Increased	48612487	1	48612488	0.0	8.2	8.2	286.2	28616.6	-1.9	-0.1	1.8
Increased	48612484	4	48612488	2.2	2.5	0.3	1.2	123.3	-1.4	-1.4	0.1
Sites found for donor
Increased	48612486	2	48612488	0.5	2.8	2.3	4.9	489.0	-2.3	-1.6	0.7
No Change	48612477	11	48612488	1.8	1.8	0.0	1.0	100	-1.9	-1.9	0.0
No Change	48612468	20	48612488	1.4	1.4	0.0	1.0	100	-2.0	-2.0	0.0
No Change	48612459	29	48612488	2.5	2.5	0.0	1.0	100	-1.7	-1.7	0.0

IVS26+1G>A

Instruction: c48612433t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	48612409	24	48612433	2.0	2.4	0.4	1.3	130.5	-1.5	-1.4	0.1
No Change	48612398	35	48612433	3.2	3.2	0.0	1.0	100	-1.2	-1.2	0.0
No Change	48612396	37	48612433	3.8	3.8	0.0	1.0	100	-1.1	-1.1	0.0
No Change	48612393	40	48612433	4.3	4.3	0.0	1.0	100	-1.0	-1.0	0.0
No Change	48612388	45	48612433	3.1	3.1	0.0	1.0	100	-1.3	-1.3	0.0
No Change	48612387	46	48612433	1.0	1.0	0.0	1.0	100	-1.7	-1.7	0.0
No Change	48612384	49	48612433	1.4	1.4	0.0	1.0	100	-1.6	-1.6	0.0
Sites found for donor
No Change	48612477	-44	48612433	1.8	1.8	0.0	1.0	100	-1.9	-1.9	0.0
No Change	48612468	-35	48612433	1.4	1.4	0.0	1.0	100	-2.0	-2.0	0.0
No Change	48612459	-26	48612433	2.5	2.5	0.0	1.0	100	-1.7	-1.7	0.0
No Change	48612429	4	48612433	0.8	0.8	0.0	1.0	100	-2.2	-2.2	0.0
Decreased	48612433	0	48612433	5.4	-7.4	-12.8	-42.4	NA	-0.8	-4.7	-3.9

IVS26+1G>T

Instruction: c48612433a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	48612409	24	48612433	2.0	2.9	0.8	1.8	179.6	-1.5	-1.3	0.2
No Change	48612398	35	48612433	3.2	3.2	0.0	1.0	100	-1.2	-1.2	0.0
No Change	48612396	37	48612433	3.8	3.8	0.0	1.0	100	-1.1	-1.1	0.0
No Change	48612393	40	48612433	4.3	4.3	0.0	1.0	100	-1.0	-1.0	0.0
No Change	48612388	45	48612433	3.1	3.1	0.0	1.0	100	-1.3	-1.3	0.0
No Change	48612387	46	48612433	1.0	1.0	0.0	1.0	100	-1.7	-1.7	0.0
No Change	48612384	49	48612433	1.4	1.4	0.0	1.0	100	-1.6	-1.6	0.0
increased	48612429	4	48612433	-2.0	1.1	3.1	2.2	219.3	-2.4	-1.7	0.7
Sites found for donor
No Change	48612477	-44	48612433	1.8	1.8	0.0	1.0	100	-1.9	-1.9	0.0
No Change	48612468	-35	48612433	1.4	1.4	0.0	1.0	100	-2.0	-2.0	0.0
No Change	48612459	-26	48612433	2.5	2.5	0.0	1.0	100	-1.7	-1.7	0.0
No Change	48612429	4	48612433	0.8	0.8	0.0	1.0	100	-2.2	-2.2	0.0
Decreased	48612433	0	48612433	5.4	-2.4	-7.8	-42.4	NA	-0.8	-3.2	-2.4

IVS26-2A>C

Instruction: t48612292g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	48612294	-3	48612291	4.5	4.1	-0.5	-1.4	72.3	-0.9	-1.1	-0.1
Decreased	48612291	0	48612291	15.4	8.0	-7.4	-171.7	0.5	1.4	-0.2	-1.6
Increased	48612290	1	48612291	1.3	5.5	4.2	18.7	1870.1	-1.7	-0.7	0.9
increased	48612281	10	48612291	-0.6	1.5	2.0	2.8	280.8	-2.1	-1.6	0.4
increased	48612275	16	48612291	-0.2	1.0	1.2	2.0	196.5	-2.0	-1.7	0.3
Sites found for donor
No Change	48612271	20	48612291	0.8	0.8	0.0	1.0	100	-2.2	-2.2	0.0

IVS27-1G>C

Instruction: c48612134g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	48612159	-25	48612134	1.6	1.6	0.0	1.0	100	-1.6	-1.6	0.0
No Change	48612150	-16	48612134	5.4	5.4	0.0	1.0	100	-0.8	-0.8	0.0
Decreased	48612134	0	48612134	8.8	1.6	-7.3	-156.4	0.6	-0.0	-1.6	-1.6
Sites found for donor
No Change	48612159	-25	48612134	2.7	2.7	0.0	1.0	100	-1.6	-1.6	0.0
No Change	48612123	11	48612134	1.6	1.6	0.0	1.0	100	-2.0	-2.0	0.0
No Change	48612114	20	48612134	6.2	6.2	0.0	1.0	100	-0.5	-0.5	0.0

IVS41+4A>C

Instruction: t48608339g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	48608316	26	48608342	1.7	2.2	0.5	1.4	143.5	-1.6	-1.4	0.1
No Change	48608307	35	48608342	4.2	4.2	0.0	1.0	100	-1.0	-1.0	0.0
Sites found for donor
No Change	48608359	-17	48608342	6.5	6.5	0.0	1.0	100	-0.5	-0.5	0.0
No Change	48608347	-5	48608342	5.4	5.4	0.0	1.0	100	-0.8	-0.8	0.0
Decreased	48608342	0	48608342	9.8	6.7	-3.1	-8.4	11.9	0.5	-0.4	-0.9

IVS47+1G>A

Instruction: c48606454t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	48606447	7	48606454	2.0	2.0	0.0	1.0	100	-1.5	-1.5	0.0
Increased	48606431	23	48606454	0.9	1.2	0.3	1.2	124.0	-1.7	-1.7	0.1
No Change	48606426	28	48606454	0.9	0.9	0.0	1.0	100	-1.7	-1.7	0.0
No Change	48606416	38	48606454	8.3	8.3	0.0	1.0	100	-0.1	-0.1	0.0
No Change	48606407	47	48606454	2.2	2.2	0.0	1.0	100	-1.5	-1.5	0.0
Sites found for donor
No Change	48606471	-17	48606454	4.9	4.9	0.0	1.0	100	-1.0	-1.0	0.0
Decreased	48606454	0	48606454	3.0	-9.8	-12.8	-8.2	NA	-1.5	-5.4	-3.9

IVS47-3C>G

Instruction: g48606365c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	48606368	-5	48606363	4.6	4.6	0.0	1.0	100	-0.9	-0.9	0.0
Decreased	48606363	0	48606363	15.2	9.3	-6.0	-62.7	1.5	1.4	0.1	-1.3
Decreased	48606362	1	48606363	0.5	0.3	-0.2	-1.2	86.5	-1.8	-1.9	-0.0
No Change	48606335	28	48606363	3.1	3.1	0.0	1.0	100	-1.3	-1.3	0.0
No Change	48606326	37	48606363	3.4	3.4	0.0	1.0	100	-1.2	-1.2	0.0
No Change	48606316	47	48606363	10.3	10.3	0.0	1.0	100	0.3	0.3	0.0
increased	48606366	-3	48606363	-0.2	1.7	1.9	3.3	333.4	-2.0	-1.6	0.4
increased	48606365	-2