Gene: BRCA2
mRNA Accession: U43746
Chromosome: chr 13

Sequence Walker  




1742T>C


Instruction: t31843765c ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 31843748 -41331844161 11.4 11.4 0.0 1.0100 0.5 0.5 0.0
No Change 31843749 -41231844161 1.1 1.1 0.0 1.0100 -1.7 -1.7 0.0
No Change 31843815 -34631844161 4.4 4.4 0.0 1.0100 -1.0 -1.0 0.0
Sites found for donor
No Change 31843731 -43031844161 0.2 0.2 0.0 1.0100 -2.4 -2.4 0.0
No Change 31843750 -41131844161 1.7 1.7 0.0 1.0100 -1.9 -1.9 0.0
No Change 31843803 -35831844161 1.3 1.3 0.0 1.0100 -2.1 -2.1 0.0



6893A>G


Instruction: a31851793g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 31851778 -19231851970 0.7 0.7 0.0 1.0100 -1.8 -1.8 0.0
No Change 31851780 -19031851970 4.6 4.6 0.0 1.0100 -0.9 -0.9 0.0
No Change 31851786 -18431851970 2.0 2.0 0.0 1.0100 -1.5 -1.5 0.0
Sites found for donor
No Change 31851759 -21131851970 0.4 0.4 0.0 1.0100 -2.3 -2.3 0.0



5416A>T


Instruction: a31850316t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 31850356 -161431851970 0.2 0.2 0.0 1.0100 -1.9 -1.9 0.0
Sites found for donor
No Change 31850273 -169731851970 1.0 1.0 0.0 1.0100 -2.1 -2.1 0.0
No Change 31850346 -162431851970 0.0 0.0 0.0 1.0100 -2.4 -2.4 0.0
No Change 31850350 -162031851970 2.9 2.9 0.0 1.0100 -1.5 -1.5 0.0



5868T>G


Instruction: t31850768g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Sites found for donor
No Change 31850740 -123031851970 0.8 0.8 0.0 1.0100 -2.2 -2.2 0.0
No Change 31850745 -122531851970 5.6 5.6 0.0 1.0100 -0.7 -0.7 0.0
No Change 31850803 -116731851970 1.7 1.7 0.0 1.0100 -1.9 -1.9 0.0



4035T>C


Instruction: t31848935c ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 31848916 187931847037 0.9 0.9 0.0 1.0100 -1.7 -1.7 0.0
Decreased31848950 1913 31847037 3.1 2.8 -0.2 -1.286.1 -1.3 -1.3 -0.0
Decreased31848954 1917 31847037 0.5 0.2 -0.3 -1.280.4 -1.8 -1.9 -0.1
Sites found for donor
No Change 31848891 185431847037 4.8 4.8 0.0 1.0100 -1.0 -1.0 0.0
No Change 31848916 187931847037 6.6 6.6 0.0 1.0100 -0.4 -0.4 0.0
No Change 31848975 193831847037 7.6 7.6 0.0 1.0100 -0.1 -0.1 0.0
No Change 31848979 194231847037 2.6 2.6 0.0 1.0100 -1.7 -1.7 0.0



6631A>C


Instruction: a31851531c ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 31851558 -41231851970 3.0 3.0 0.0 1.0100 -1.3 -1.3 0.0
increased31851546-42431851970 -1.1 0.2 1.3 1.2118.0 -2.2 -1.9 0.3
Sites found for donor
No Change 31851480 -49031851970 0.1 0.1 0.0 1.0100 -2.4 -2.4 0.0
No Change 31851508 -46231851970 1.8 1.8 0.0 1.0100 -1.9 -1.9 0.0
No Change 31851547 -42331851970 5.5 5.5 0.0 1.0100 -0.8 -0.8 0.0



9179C>G


Instruction: c31890286g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 31890318 2931890289 6.0 6.0 0.0 1.0100 -0.6 -0.6 0.0
Sites found for donor
No Change 31890240 -4931890289 1.8 1.8 0.0 1.0100 -1.9 -1.9 0.0
No Change 31890249 -4031890289 1.3 1.3 0.0 1.0100 -2.0 -2.0 0.0
No Change 31890258 -3131890289 5.2 5.2 0.0 1.0100 -0.9 -0.9 0.0
Decreased31890289 0 31890289 12.7 11.6 -1.2 -2.244.7 1.4 1.1 -0.4
No Change 31890293 431890289 5.0 5.0 0.0 1.0100 -0.9 -0.9 0.0
No Change 31890297 831890289 4.7 4.7 0.0 1.0100 -1.0 -1.0 0.0



5972C>T


Instruction: c31850872t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 31850853 -111731851970 4.8 4.8 0.0 1.0100 -0.9 -0.9 0.0
No Change 31850903 -106731851970 4.8 4.8 0.0 1.0100 -0.9 -0.9 0.0
Sites found for donor
Decreased31850866 -1104 31851970 0.9 0.6 -0.3 -1.280.2 -2.1 -2.2 -0.1
No Change 31850886 -108431851970 1.5 1.5 0.0 1.0100 -2.0 -2.0 0.0
No Change 31850905 -106531851970 2.1 2.1 0.0 1.0100 -1.8 -1.8 0.0



6174delT


Instruction: d31851074,31851074 ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 31851064 -90631851970 1.4 1.4 0.0 1.0100 -1.6 -1.6 0.0
No Change 31851069 -90131851970 2.4 2.4 0.0 1.0100 -1.4 -1.4 0.0
Sites found for donor
No Change 31851029 -94131851970 3.1 3.1 0.0 1.0100 -1.5 -1.5 0.0
No Change 31851052 -91831851970 2.2 2.2 0.0 1.0100 -1.8 -1.8 0.0
No Change 31851090 -88031851970 4.5 4.5 0.0 1.0100 -1.1 -1.1 0.0
Decreased31851069-90131851970 0.4 -0.8 -1.2 -1.3NA -2.3 -2.7 -0.4
Decreased31851073-89731851970 1.6 -4.0 -5.6 -3.0NA -1.9 -3.7 -1.7



5909insA


Instruction: i31850809,31850810a ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 31850853 -111731851970 4.8 4.8 0.0 1.0100 -0.9 -0.9 0.0
Sites found for donor
No Change 31850803 -116731851970 1.7 1.7 0.0 1.0100 -1.9 -1.9 0.0



6630delTAACT


Instruction: d31851526,31851530 ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 31851558 -41231851970 3.0 3.0 0.0 1.0100 -1.3 -1.3 0.0
increased31851546-42431851970 -1.1 0.1 1.2 1.1105.1 -2.2 -1.9 0.3
Sites found for donor
No Change 31851480 -49031851970 0.1 0.1 0.0 1.0100 -2.4 -2.4 0.0
No Change 31851508 -46231851970 1.8 1.8 0.0 1.0100 -1.9 -1.9 0.0
No Change 31851547 -42331851970 5.5 5.5 0.0 1.0100 -0.8 -0.8 0.0