Gene: SPAST
mRNA Accession: AJ246001
Chromosome: chr 2

Sequence Walker  




334G>T


Instruction: g32246944t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 32246976 -5032247026 3.0 3.0 0.0 1.0100 -1.3 -1.3 0.0
Sites found for donor
No Change 32246932 -9432247026 2.5 2.5 0.0 1.0100 -1.7 -1.7 0.0
No Change 32246985 -4132247026 0.6 0.6 0.0 1.0100 -2.3 -2.3 0.0
Decreased32246942-8432247026 0.2 -3.9 -4.1 -1.2NA -2.4 -3.6 -1.2



1005-1G>T


Instruction: g32298897t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 32298872 -2532298897 5.8 5.8 0.0 1.0100 -0.7 -0.7 0.0
Increased 32298905 832298897 1.3 3.2 1.9 3.8378.6 -1.7 -1.2 0.4
Decreased32298897032298897 3.6 -5.2 -8.7 -12.0NA -1.2 -3.1 -1.9
increased32298899232298897 -1.9 2.4 4.3 5.2520.4 -2.4 -1.4 0.9
Sites found for donor
No Change 32298930 3332298897 1.1 1.1 0.0 1.0100 -2.1 -2.1 0.0



1134_1135delGT


Instruction: d32309762,32309763 ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 32309736 1032309726 9.5 9.5 0.0 1.0100 0.1 0.1 0.0
No Change 32309755 2932309726 1.7 1.7 0.0 1.0100 -1.6 -1.6 0.0
Decreased323097815532309726 0.0 -6.9 -6.9 -1.0NA -1.9 -3.4 -1.5
Sites found for donor
No Change 32309712 -1432309726 2.9 2.9 0.0 1.0100 -1.6 -1.6 0.0
No Change 32309788 6232309726 0.4 0.4 0.0 1.0100 -2.3 -2.3 0.0
No Change 32309802 7632309726 9.8 9.8 0.0 1.0100 0.5 0.5 0.0



1508G>T


Instruction: g32324697t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 32324682 032324682 9.0 9.0 0.0 1.0100 0.0 0.0 0.0
Sites found for donor
No Change 32324662 -2032324682 1.3 1.3 0.0 1.0100 -2.0 -2.0 0.0
Increased 32324699 1732324682 4.2 4.4 0.2 1.1112.3 -1.1 -1.1 0.1
No Change 32324726 4432324682 8.5 8.5 0.0 1.0100 0.1 0.1 0.0
No Change 32324730 4832324682 1.2 1.2 0.0 1.0100 -2.1 -2.1 0.0



1577_1580delGAAG


Instruction: d32326155,32326158 ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Sites found for donor
No Change 32326146 3232326114 2.9 2.9 0.0 1.0100 -1.6 -1.6 0.0
No Change 32326195 8132326114 10.7 10.7 0.0 1.0100 0.8 0.8 0.0
No Change 32326199 8532326114 1.3 1.3 0.0 1.0100 -2.0 -2.0 0.0
Decreased323261544032326114 1.3 -2.2 -3.5 -2.4NA -2.1 -3.1 -1.1



1720delG


Instruction: d32330029,32330029 ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 32330075 3732330038 2.9 2.9 0.0 1.0100 -1.3 -1.3 0.0
No Change 32330077 3932330038 1.7 1.7 0.0 1.0100 -1.6 -1.6 0.0
No Change 32330079 4132330038 2.0 2.0 0.0 1.0100 -1.5 -1.5 0.0
Sites found for donor
No Change 32330014 -2432330038 7.6 7.6 0.0 1.0100 -0.1 -0.1 0.0
No Change 32330033 -532330038 5.5 5.5 0.0 1.0100 -0.8 -0.8 0.0
No Change 32330038 032330038 3.2 3.2 0.0 1.0100 -1.5 -1.5 0.0



1728+2T>A


Instruction: t32330039a ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 32330075 3732330038 2.9 2.9 0.0 1.0100 -1.3 -1.3 0.0
No Change 32330077 3932330038 1.7 1.7 0.0 1.0100 -1.6 -1.6 0.0
No Change 32330079 4132330038 2.0 2.0 0.0 1.0100 -1.5 -1.5 0.0
No Change 32330082 4432330038 4.0 4.0 0.0 1.0100 -1.1 -1.1 0.0
No Change 32330083 4532330038 4.6 4.6 0.0 1.0100 -0.9 -0.9 0.0
Sites found for donor
No Change 32330014 -2432330038 7.6 7.6 0.0 1.0100 -0.1 -0.1 0.0
Increased 32330033 -532330038 5.5 6.0 0.5 1.4144.5 -0.8 -0.6 0.2
No Change 32330079 4132330038 5.3 5.3 0.0 1.0100 -0.8 -0.8 0.0
Decreased32330038032330038 3.2 -4.6 -7.8 -9.2NA -1.5 -3.8 -2.4