Gene: USH1C
mRNA Accession: BC016057
Mutation:USH1C.txt
Chromosome: chr 11

Sequence Walker  




+1188A>G


Instruction: t17578141c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 17578179 -3 17578176 3.2 3.2 0.0 1.0 100 -1.5 -1.5 0.0
No change 17578109 67 17578176 0.7 0.7 0.0 1.0 100 -2.2 -2.2 0.0
No change 17578101 75 17578176 4.1 4.1 0.0 1.0 100 -1.2 -1.2 0.0



+1877C>T


Instruction: g17554790a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 17554840 -239 17554601 3.0 3.0 0.0 1.0 100 -1.5 -1.5 0.0
No change 17554770 -169 17554601 3.2 3.2 0.0 1.0 100 -1.5 -1.5 0.0



+381G>T


Instruction: c17591861a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 17591880 -26 17591854 3.3 3.3 0.0 1.0 100 -1.4 -1.4 0.0
No change 17591854 0 17591854 10.9 10.9 0.0 1.0 100 0.9 0.9 0.0
No change 17591835 19 17591854 1.0 1.0 0.0 1.0 100 -2.1 -2.1 0.0
No change 17591829 25 17591854 0.7 0.7 0.0 1.0 100 -2.2 -2.2 0.0



+91C>T


Instruction: g17593969a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 17593964 -9 17593955 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0
No change 17593955 0 17593955 8.1 8.1 0.0 1.0 100 0.0 0.0 0.0
No change 17593951 4 17593955 2.6 2.6 0.0 1.0 100 -1.6 -1.6 0.0
No change 17593931 24 17593955 2.7 2.7 0.0 1.0 100 -1.6 -1.6 0.0
Increased 17593970 -15 17593955 -4.8 2.7 7.5 6.5 654.8 -3.9 -1.6 2.3



IVS1-41insCC


Instruction: i17594063,17594064gg; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 17594082 -58 17594024 1.7 1.7 0.0 1.0 100 -1.9 -1.9 0.0
Decreased 17594065 -41 17594024 1.8 0.6 -1.2 -2.3 43.3 -1.9 -2.2 -0.4
No change 17594048 -24 17594024 1.7 1.7 0.0 1.0 100 -1.9 -1.9 0.0
No change 17594023 1 17594024 5.7 5.7 0.0 1.0 100 -0.7 -0.7 0.0



IVS1-45C>G


Instruction: g17594068c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 17594116 -92 17594024 0.6 0.6 0.0 1.0 100 -2.3 -2.3 0.0
No change 17594082 -58 17594024 1.7 1.7 0.0 1.0 100 -1.9 -1.9 0.0
Decreased 17594065 -41 17594024 1.8 0.7 -1.2 -2.2 44.7 -1.9 -2.2 -0.4
No change 17594048 -24 17594024 1.7 1.7 0.0 1.0 100 -1.9 -1.9 0.0
No change 17594023 1 17594024 5.7 5.7 0.0 1.0 100 -0.7 -0.7 0.0



IVS1-47G>T


Instruction: c17594070a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 17594116 -92 17594024 0.6 0.6 0.0 1.0 100 -2.3 -2.3 0.0
No change 17594082 -58 17594024 1.7 1.7 0.0 1.0 100 -1.9 -1.9 0.0
No change 17594065 -41 17594024 1.8 1.8 0.0 1.0 100 -1.9 -1.9 0.0
No change 17594048 -24 17594024 1.7 1.7 0.0 1.0 100 -1.9 -1.9 0.0
No change 17594023 1 17594024 5.7 5.7 0.0 1.0 100 -0.7 -0.7 0.0
Increased 17594071 -47 17594024 -3.7 4.6 8.2 23.5 2348.4 -3.5 -1.0 2.5



IVS13-45A>G


Instruction: t17578220c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 17578179 -3 17578176 3.2 3.2 0.0 1.0 100 -1.5 -1.5 0.0



IVS17-113A>G


Instruction: t17559085c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 17559131 -158 17558973 5.8 5.8 0.0 1.0 100 -0.7 -0.7 0.0
No change 17559072 -99 17558973 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0



IVS2-16C>T


Instruction: g17592259a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 17592298 -54 17592244 1.8 1.8 0.0 1.0 100 -1.9 -1.9 0.0
No change 17592289 -45 17592244 2.0 2.0 0.0 1.0 100 -1.8 -1.8 0.0
No change 17592276 -32 17592244 7.4 7.4 0.0 1.0 100 -0.2 -0.2 0.0
No change 17592221 23 17592244 2.4 2.4 0.0 1.0 100 -1.7 -1.7 0.0



IVS5+1G>A


Instruction: c17587923t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 17587972 -49 17587923 1.4 1.4 0.0 1.0 100 -2.0 -2.0 0.0
No change 17587930 -7 17587923 7.3 7.3 0.0 1.0 100 -0.2 -0.2 0.0
No change 17587919 4 17587923 4.0 4.0 0.0 1.0 100 -1.2 -1.2 0.0
No change 17587887 36 17587923 6.4 6.4 0.0 1.0 100 -0.5 -0.5 0.0
Decreased 17587923 0 17587923 7.5 -5.3 -12.8 -184.4 NA -0.1 -4.0 -3.9



IVS6-45delC


Instruction: d17587786,17587786; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 17587822 -80 17587742 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0
No change 17587814 -72 17587742 7.9 7.9 0.0 1.0 100 -0.0 -0.0 0.0
No change 17587797 -55 17587742 6.4 6.4 0.0 1.0 100 -0.5 -0.5 0.0



IVS7+61G>A


Instruction: c17587393t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 17587435 18 17587453 2.2 2.2 0.0 1.0 100 -1.8 -1.8 0.0
No change 17587427 26 17587453 0.9 0.9 0.0 1.0 100 -2.2 -2.2 0.0
No change 17587421 32 17587453 4.1 4.1 0.0 1.0 100 -1.2 -1.2 0.0
No change 17587404 49 17587453 0.1 0.1 0.0 1.0 100 -2.4 -2.4 0.0
Decreased 17587399 54 17587453 1.3 1.0 -0.4 -1.3 75.8 -2.0 -2.1 -0.1
No change 17587383 70 17587453 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0



IVS7-27G>A


Instruction: c17587169t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 17587180 -37 17587143 1.5 1.5 0.0 1.0 100 -2.0 -2.0 0.0
No change 17587139 4 17587143 0.6 0.6 0.0 1.0 100 -2.3 -2.3 0.0
Decreased 17587169 -26 17587143 0.5 -12.3 -12.8 -1.4 NA -2.3 -6.2 -3.9



IVS9-66T>C


Instruction: a17584245g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 17584295 -115 17584180 3.2 3.2 0.0 1.0 100 -1.5 -1.5 0.0

Legend:    Site Abolished   Leaky Site   Cryptic Site created   Strengthened Pre-existing site   Pre-existing Site   Weakened Pre-existing Site