Gene: USH1C
mRNA Accession: BC016057
Chromosome: chr 11

Sequence Walker  




+91C>T


Instruction: g17593969a ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 17593937 1817593955 0.2 0.2 0.0 1.0100 -1.9 -1.9 0.0
Sites found for donor
No Change 17593964 -917593955 0.4 0.4 0.0 1.0100 -2.3 -2.3 0.0
No Change 17593955 017593955 8.1 8.1 0.0 1.0100 0.0 0.0 0.0
No Change 17593951 417593955 2.6 2.6 0.0 1.0100 -1.6 -1.6 0.0
No Change 17593931 2417593955 2.7 2.7 0.0 1.0100 -1.6 -1.6 0.0
increased17593970-1517593955 -4.8 2.7 7.5 6.5654.8 -3.9 -1.6 2.3



IVS5+1G>A


Instruction: c17587923t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Sites found for donor
No Change 17587972 -4917587923 1.4 1.4 0.0 1.0100 -2.0 -2.0 0.0
No Change 17587930 -717587923 7.3 7.3 0.0 1.0100 -0.2 -0.2 0.0
No Change 17587919 417587923 4.0 4.0 0.0 1.0100 -1.2 -1.2 0.0
No Change 17587887 3617587923 6.4 6.4 0.0 1.0100 -0.5 -0.5 0.0
Decreased17587923017587923 7.5 -5.3 -12.8 -184.4NA -0.1 -4.0 -3.9



IVS1-41insCC


Instruction: i17594063,17594064gg ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 17594085 -6117594024 0.2 0.2 0.0 1.0100 -1.9 -1.9 0.0
No Change 17594083 -5917594024 3.7 3.7 0.0 1.0100 -1.1 -1.1 0.0
No Change 17594024 017594024 8.6 8.6 0.0 1.0100 -0.1 -0.1 0.0
Sites found for donor
No Change 17594082 -5817594024 1.7 1.7 0.0 1.0100 -1.9 -1.9 0.0
Decreased17594065 -41 17594024 1.8 0.6 -1.2 -2.343.3 -1.9 -2.2 -0.4
No Change 17594048 -2417594024 1.7 1.7 0.0 1.0100 -1.9 -1.9 0.0
No Change 17594023 117594024 5.7 5.7 0.0 1.0100 -0.7 -0.7 0.0



IVS1-45C>G


Instruction: g17594068c ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 17594085 -6117594024 0.2 0.2 0.0 1.0100 -1.9 -1.9 0.0
No Change 17594083 -5917594024 3.7 3.7 0.0 1.0100 -1.1 -1.1 0.0
No Change 17594024 017594024 8.6 8.6 0.0 1.0100 -0.1 -0.1 0.0
Sites found for donor
No Change 17594116 -9217594024 0.6 0.6 0.0 1.0100 -2.3 -2.3 0.0
No Change 17594082 -5817594024 1.7 1.7 0.0 1.0100 -1.9 -1.9 0.0
Decreased17594065 -41 17594024 1.8 0.7 -1.2 -2.244.7 -1.9 -2.2 -0.4
No Change 17594048 -2417594024 1.7 1.7 0.0 1.0100 -1.9 -1.9 0.0
No Change 17594023 117594024 5.7 5.7 0.0 1.0100 -0.7 -0.7 0.0



IVS1-47G>T


Instruction: c17594070a ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 17594085 -6117594024 0.2 0.2 0.0 1.0100 -1.9 -1.9 0.0
No Change 17594083 -5917594024 3.7 3.7 0.0 1.0100 -1.1 -1.1 0.0
No Change 17594024 017594024 8.6 8.6 0.0 1.0100 -0.1 -0.1 0.0
Sites found for donor
No Change 17594116 -9217594024 0.6 0.6 0.0 1.0100 -2.3 -2.3 0.0
No Change 17594082 -5817594024 1.7 1.7 0.0 1.0100 -1.9 -1.9 0.0
No Change 17594065 -4117594024 1.8 1.8 0.0 1.0100 -1.9 -1.9 0.0
No Change 17594048 -2417594024 1.7 1.7 0.0 1.0100 -1.9 -1.9 0.0
No Change 17594023 117594024 5.7 5.7 0.0 1.0100 -0.7 -0.7 0.0
increased17594071-4717594024 -3.7 4.6 8.2 23.52348.4 -3.5 -1.0 2.5



IVS2-16C>T


Instruction: g17592259a ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Increased 17592244 017592244 7.1 7.4 0.2 1.2116.1 -0.4 -0.3 0.0
Sites found for donor
No Change 17592298 -5417592244 1.8 1.8 0.0 1.0100 -1.9 -1.9 0.0
No Change 17592289 -4517592244 2.0 2.0 0.0 1.0100 -1.8 -1.8 0.0
No Change 17592276 -3217592244 7.4 7.4 0.0 1.0100 -0.2 -0.2 0.0
No Change 17592221 2317592244 2.4 2.4 0.0 1.0100 -1.7 -1.7 0.0



+381G>T


Instruction: c17591861a ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 17591884 -3017591854 5.8 5.8 0.0 1.0100 -0.7 -0.7 0.0
increased17591855-117591854 -0.1 2.1 2.2 4.4436.2 -2.0 -1.5 0.5
Sites found for donor
No Change 17591880 -2617591854 3.3 3.3 0.0 1.0100 -1.4 -1.4 0.0
No Change 17591854 017591854 10.9 10.9 0.0 1.0100 0.9 0.9 0.0
No Change 17591835 1917591854 1.0 1.0 0.0 1.0100 -2.1 -2.1 0.0
No Change 17591829 2517591854 0.7 0.7 0.0 1.0100 -2.2 -2.2 0.0



IVS6-45delC


Instruction: d17587786,17587786 ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 17587745 -317587742 2.8 2.8 0.0 1.0100 -1.3 -1.3 0.0
No Change 17587742 017587742 12.6 12.6 0.0 1.0100 0.8 0.8 0.0
Sites found for donor
No Change 17587822 -8017587742 0.4 0.4 0.0 1.0100 -2.3 -2.3 0.0
No Change 17587814 -7217587742 7.9 7.9 0.0 1.0100 -0.0 -0.0 0.0
No Change 17587797 -5517587742 6.4 6.4 0.0 1.0100 -0.5 -0.5 0.0



IVS7+61G>A


Instruction: c17587393t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 17587354 9917587453 1.6 1.6 0.0 1.0100 -1.6 -1.6 0.0
No Change 17587341 11217587453 1.9 1.9 0.0 1.0100 -1.5 -1.5 0.0
Sites found for donor
No Change 17587435 1817587453 2.2 2.2 0.0 1.0100 -1.8 -1.8 0.0
No Change 17587427 2617587453 0.9 0.9 0.0 1.0100 -2.2 -2.2 0.0
No Change 17587421 3217587453 4.1 4.1 0.0 1.0100 -1.2 -1.2 0.0
No Change 17587404 4917587453 0.1 0.1 0.0 1.0100 -2.4 -2.4 0.0
Decreased17587399 54 17587453 1.3 1.0 -0.4 -1.375.8 -2.0 -2.1 -0.1
No Change 17587383 7017587453 0.4 0.4 0.0 1.0100 -2.3 -2.3 0.0



IVS7-27G>A


Instruction: c17587169t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 17587143 017587143 13.9 13.9 0.0 1.0100 1.1 1.1 0.0
No Change 17587142 117587143 2.0 2.0 0.0 1.0100 -1.5 -1.5 0.0
Sites found for donor
No Change 17587180 -3717587143 1.5 1.5 0.0 1.0100 -2.0 -2.0 0.0
No Change 17587139 417587143 0.6 0.6 0.0 1.0100 -2.3 -2.3 0.0
Decreased17587169-2617587143 0.5 -12.3 -12.8 -1.4NA -2.3 -6.2 -3.9



IVS9-66T>C


Instruction: a17584245g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 17584262 -8217584180 0.6 0.6 0.0 1.0100 -1.8 -1.8 0.0
Decreased17584236 -56 17584180 4.3 3.7 -0.6 -1.566.7 -1.0 -1.1 -0.1
Sites found for donor
No Change 17584295 -11517584180 3.2 3.2 0.0 1.0100 -1.5 -1.5 0.0



IVS13+21C>G


Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Unprocessed due to the following error. IVS13+21C>G the old base at 17581550 is NOT g! It is c.



IVS13-42G>A


Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Unprocessed due to the following error. IVS13-42G>A the old base at 17578217 is NOT c! It is a.



IVS13-45A>G


Instruction: t17578220c ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Decreased17578218 -42 17578176 2.2 0.5 -1.7 -3.329.8 -1.5 -1.8 -0.4
Decreased17578200 -24 17578176 8.9 8.6 -0.3 -1.281.8 0.0 -0.1 -0.1
No Change 17578181 -517578176 8.2 8.2 0.0 1.0100 -0.1 -0.1 0.0
No Change 17578180 -417578176 6.6 6.6 0.0 1.0100 -0.5 -0.5 0.0
No Change 17578176 017578176 9.2 9.2 0.0 1.0100 0.1 0.1 0.0
No Change 17578168 817578176 2.2 2.2 0.0 1.0100 -1.5 -1.5 0.0
Decreased17578219-4317578176 1.0 -7.2 -8.2 -2.0NA -1.7 -3.5 -1.8
Sites found for donor
No Change 17578179 -317578176 3.2 3.2 0.0 1.0100 -1.5 -1.5 0.0



IVS13-108A>G


Instruction: t17578283c ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 17578298 -12217578176 1.6 1.6 0.0 1.0100 -1.6 -1.6 0.0
No Change 17578291 -11517578176 1.6 1.6 0.0 1.0100 -1.6 -1.6 0.0
No Change 17578289 -11317578176 9.4 9.4 0.0 1.0100 0.1 0.1 0.0
Decreased17578278 -102 17578176 1.3 1.2 -0.2 -1.189.4 -1.6 -1.7 -0.0
Sites found for donor



+1188A>G


Instruction: t17578141c ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 17578168 817578176 2.2 2.2 0.0 1.0100 -1.5 -1.5 0.0
Decreased175781403617578176 1.6 -6.5 -8.2 -3.1NA -1.6 -3.4 -1.8
Sites found for donor
No Change 17578179 -317578176 3.2 3.2 0.0 1.0100 -1.5 -1.5 0.0
No Change 17578109 6717578176 0.7 0.7 0.0 1.0100 -2.2 -2.2 0.0
No Change 17578101 7517578176 4.1 4.1 0.0 1.0100 -1.2 -1.2 0.0



IVSA-34C>T


Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Unprocessed due to the following error. Information of Exon A is not found



IVSB+52C>T


Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Unprocessed due to the following error.  Information of Exon B is not found



IVSB-34G>A


Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Unprocessed due to the following error. Information of Exon B is not found



IVSC+121T>A


Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Unprocessed due to the following error.Information of Exon C is not found.



IVSC-64C>A


Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Unprocessed due to the following error. Information of Exon C is not found.



IVSE-12T>C


Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Unprocessed due to the following error. Information of Exon E is not found



IVS16+12C>T


Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Unprocessed due to the following error. IVS16+12C>T the old base at 17562171 is NOT g! It is a.



IVS17-113A>G


Instruction: t17559085c ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 17559105 -13217558973 1.7 1.7 0.0 1.0100 -1.6 -1.6 0.0
No Change 17559103 -13017558973 2.7 2.7 0.0 1.0100 -1.4 -1.4 0.0
No Change 17559098 -12517558973 1.5 1.5 0.0 1.0100 -1.6 -1.6 0.0
No Change 17559096 -12317558973 1.2 1.2 0.0 1.0100 -1.7 -1.7 0.0
Increased 17559086 -11317558973 3.6 4.6 1.0 1.9193.9 -1.2 -0.9 0.2
Decreased17559079 -106 17558973 1.8 1.8 -0.1 -1.095.7 -1.5 -1.6 -0.0
No Change 17559034 -6117558973 0.9 0.9 0.0 1.0100 -1.7 -1.7 0.0
increased17559073-10017558973 -0.2 0.3 0.5 1.2120.0 -2.0 -1.9 0.1
Sites found for donor
No Change 17559131 -15817558973 5.8 5.8 0.0 1.0100 -0.7 -0.7 0.0
No Change 17559072 -9917558973 0.4 0.4 0.0 1.0100 -2.3 -2.3 0.0



+1440C>T


Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Unprocessed due to the following error. +1440C>T the old base at 17558956 is NOT g! It is c.



+1557G>C


Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Unprocessed due to the following error. +1557G>C the old base at 17557491 is NOT c! It is g.



IVS19+12G>C


Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Unprocessed due to the following error. IVS19+12G>C the old base at 17557447 is NOT c! It is g.



+1737T>C


Instruction: a17554930g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Decreased17554921 157 17555078 3.5 2.9 -0.6 -1.566.7 -1.2 -1.3 -0.1
No Change 17554890 18817555078 5.5 5.5 0.0 1.0100 -0.7 -0.7 0.0
Sites found for donor



+1877C>T


Instruction: g17554790a ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Increased 17554776 -17517554601 5.0 5.4 0.4 1.3130.0 -0.8 -0.8 0.1
Increased 17554775 -17417554601 2.1 2.3 0.2 1.2116.1 -1.5 -1.4 0.0
Increased 17554770 -16917554601 10.0 10.1 0.2 1.1111.8 0.2 0.3 0.0
No Change 17554751 -15017554601 5.5 5.5 0.0 1.0100 -0.7 -0.7 0.0
Sites found for donor
No Change 17554840 -23917554601 3.0 3.0 0.0 1.0100 -1.5 -1.5 0.0
No Change 17554770 -16917554601 3.2 3.2 0.0 1.0100 -1.5 -1.5 0.0



+1902A>G


Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Unprocessed due to the following error. +1902A>G the old base at 17554765 is NOT t! It is a.