Gene: RPGR
mRNA Accession: U57629
Mutation:RPGR.txt
Chromosome: chr X

Sequence Walker  




160delA


Instruction: d37027267,37027267; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 37027309 -96 37027213 5.5 5.5 0.0 1.0 100 -0.8 -0.8 0.0
No change 37027285 -72 37027213 6.7 6.7 0.0 1.0 100 -0.4 -0.4 0.0
No change 37027256 -43 37027213 0.6 0.6 0.0 1.0 100 -2.3 -2.3 0.0
No change 37027243 -30 37027213 1.7 1.7 0.0 1.0 100 -1.9 -1.9 0.0



789A>T


Instruction: t37014478a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 37014496 -67 37014429 3.6 3.6 0.0 1.0 100 -1.4 -1.4 0.0
Decreased 37014475 -46 37014429 6.6 5.2 -1.4 -2.7 36.8 -0.4 -0.9 -0.4
No change 37014466 -37 37014429 1.2 1.2 0.0 1.0 100 -2.1 -2.1 0.0
No change 37014456 -27 37014429 1.7 1.7 0.0 1.0 100 -1.9 -1.9 0.0
No change 37014442 -13 37014429 0.1 0.1 0.0 1.0 100 -2.4 -2.4 0.0
Increased 37014479 -50 37014429 -3.7 4.1 7.8 16.7 1669.5 -3.6 -1.2 2.4



IVS8+1G>C


Instruction: c37008449g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 37008410 39 37008449 1.7 1.7 0.0 1.0 100 -1.9 -1.9 0.0
Decreased 37008449 0 37008449 8.4 -1.4 -9.8 -341.8 NA 0.1 -2.9 -3.0



1147insT


Instruction: i37002927,37002928a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 37002956 1 37002957 1.2 1.2 0.0 1.0 100 -2.1 -2.1 0.0
No change 37002946 11 37002957 3.4 3.4 0.0 1.0 100 -1.4 -1.4 0.0
No change 37002932 25 37002957 3.4 3.4 0.0 1.0 100 -1.4 -1.4 0.0
No change 37002907 50 37002957 4.5 4.5 0.0 1.0 100 -1.1 -1.1 0.0

Legend:    Site Abolished   Leaky Site   Cryptic Site created   Strengthened Pre-existing site   Pre-existing Site   Weakened Pre-existing Site