Gene: RPGR
mRNA Accession: U57629
Mutation:RPGR.txt
Chromosome: chr X

Sequence Walker  




160delA


Instruction: d37027267,37027267; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 37027238 -25 37027213 3.3 3.3 0.0 1.0 100 -1.2 -1.2 0.0



IVS8+1G>C


Instruction: c37008449g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 37008474 -25 37008449 1.0 1.0 0.0 1.0 100 -1.7 -1.7 0.0
Decreased 37008450 -1 37008449 2.3 0.4 -1.9 -3.8 26.5 -1.4 -1.8 -0.4
No change 37008417 32 37008449 6.2 6.2 0.0 1.0 100 -0.6 -0.6 0.0



IVS8+1G>C

Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z )Δ Z
Increased 37002912 5537 37008449 -1.5 0.1 1.5 1.1 105.4 -2.3 -1.9 0.3
Increased 37002910 5539 37008449 -0.7 0.0 0.7 1.0 101.0 -2.1 -1.9 0.2



1366G>A


Instruction: c37001206t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 37001182 86 37001268 5.5 5.8 0.4 1.3 130.5 -0.7 -0.7 0.1
No change 37001177 91 37001268 8.3 8.3 0.0 1.0 100 -0.1 -0.1 0.0
No change 37001168 100 37001268 3.8 3.8 0.0 1.0 100 -1.1 -1.1 0.0
No change 37001157 111 37001268 0.4 0.4 0.0 1.0 100 -1.8 -1.8 0.0
Increased 37001181 87 37001268 -0.5 0.0 0.6 1.0 101.4 -2.1 -1.9 0.1

Legend:    Site Abolished   Leaky Site   Cryptic Site created   Strengthened Pre-existing site   Pre-existing Site   Weakened Pre-existing Site