Gene: PAH
mRNA Accession: U49897
Chromosome: chr 12

Sequence Walker  




IVS1nt5g>t


Instruction: c103243791a ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103243796 -1103243795 2.3 2.3 0.0 1.0100 -1.4 -1.4 0.0
No Change 103243746 49103243795 1.9 1.9 0.0 1.0100 -1.5 -1.5 0.0
Sites found for donor
No Change 103243817 -22103243795 0.8 0.8 0.0 1.0100 -2.2 -2.2 0.0
Decreased103243795 0 103243795 10.7 6.8 -3.9 -15.16.6 0.8 -0.4 -1.2
No Change 103243768 27103243795 0.7 0.7 0.0 1.0100 -2.2 -2.2 0.0
No Change 103243767 28103243795 1.5 1.5 0.0 1.0100 -2.0 -2.0 0.0



IVS2nt1g>a


Instruction: c103239515t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103239476 39103239515 0.9 0.9 0.0 1.0100 -1.7 -1.7 0.0
Sites found for donor
No Change 103239551 -36103239515 1.8 1.8 0.0 1.0100 -1.9 -1.9 0.0
No Change 103239547 -32103239515 1.5 1.5 0.0 1.0100 -2.0 -2.0 0.0
No Change 103239533 -18103239515 1.1 1.1 0.0 1.0100 -2.1 -2.1 0.0
No Change 103239498 17103239515 1.6 1.6 0.0 1.0100 -1.9 -1.9 0.0
Decreased1032395150103239515 7.2 -5.6 -12.8 -144.4NA -0.3 -4.1 -3.9



IVS2nt5g>c


Instruction: c103239511g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103239476 39103239515 0.9 0.9 0.0 1.0100 -1.7 -1.7 0.0
Sites found for donor
No Change 103239551 -36103239515 1.8 1.8 0.0 1.0100 -1.9 -1.9 0.0
No Change 103239547 -32103239515 1.5 1.5 0.0 1.0100 -2.0 -2.0 0.0
No Change 103239533 -18103239515 1.1 1.1 0.0 1.0100 -2.1 -2.1 0.0
Decreased103239515 0 103239515 7.2 3.2 -3.9 -15.56.4 -0.3 -1.5 -1.2
No Change 103239498 17103239515 1.6 1.6 0.0 1.0100 -1.9 -1.9 0.0



IVS2nt5g>t


Instruction: c103239511a ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103239476 39103239515 0.9 0.9 0.0 1.0100 -1.7 -1.7 0.0
Sites found for donor
No Change 103239551 -36103239515 1.8 1.8 0.0 1.0100 -1.9 -1.9 0.0
No Change 103239547 -32103239515 1.5 1.5 0.0 1.0100 -2.0 -2.0 0.0
No Change 103239533 -18103239515 1.1 1.1 0.0 1.0100 -2.1 -2.1 0.0
Decreased103239515 0 103239515 7.2 3.3 -3.9 -15.16.6 -0.3 -1.4 -1.2
No Change 103239498 17103239515 1.6 1.6 0.0 1.0100 -1.9 -1.9 0.0



IVS2nt6t>g


Instruction: a103239510c ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103239476 39103239515 0.9 0.9 0.0 1.0100 -1.7 -1.7 0.0
increased1032395114103239515 -0.8 1.4 2.2 2.7266.0 -2.1 -1.6 0.5
Sites found for donor
No Change 103239551 -36103239515 1.8 1.8 0.0 1.0100 -1.9 -1.9 0.0
No Change 103239547 -32103239515 1.5 1.5 0.0 1.0100 -2.0 -2.0 0.0
No Change 103239533 -18103239515 1.1 1.1 0.0 1.0100 -2.1 -2.1 0.0
Decreased103239515 0 103239515 7.2 6.0 -1.2 -2.342.8 -0.3 -0.6 -0.4
No Change 103239498 17103239515 1.6 1.6 0.0 1.0100 -1.9 -1.9 0.0



IVS2nt19t>c


Instruction: a103239497g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Decreased103239476 39 103239515 0.9 0.9 -0.1 -1.096.1 -1.7 -1.7 -0.0
No Change 103239453 62103239515 8.5 8.5 0.0 1.0100 -0.1 -0.1 0.0
No Change 103239449 66103239515 7.9 7.9 0.0 1.0100 -0.2 -0.2 0.0
Sites found for donor
No Change 103239547 -32103239515 1.5 1.5 0.0 1.0100 -2.0 -2.0 0.0
No Change 103239533 -18103239515 1.1 1.1 0.0 1.0100 -2.1 -2.1 0.0
No Change 103239515 0103239515 7.2 7.2 0.0 1.0100 -0.3 -0.3 0.0
No Change 103239453 62103239515 0.9 0.9 0.0 1.0100 -2.1 -2.1 0.0
Decreased10323949817103239515 1.6 -5.9 -7.5 -3.0NA -1.9 -4.2 -2.3
increased10320428435231103239515 -1.8 1.3 3.1 2.4239.4 -3.0 -2.1 0.9



IVS3nt-22c>t


Instruction: g103204297a ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103204300 -24103204276 4.9 4.9 0.0 1.0100 -0.9 -0.9 0.0
Increased 103204276 0103204276 7.6 7.6 0.1 1.0104.0 -0.3 -0.3 0.0
No Change 103204269 7103204276 1.3 1.3 0.0 1.0100 -1.7 -1.7 0.0
No Change 103204261 15103204276 0.5 0.5 0.0 1.0100 -1.8 -1.8 0.0
No Change 103204260 16103204276 3.3 3.3 0.0 1.0100 -1.2 -1.2 0.0
Sites found for donor



IVS3nt-6t>a


Instruction: a103204281t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103204300 -24103204276 4.9 4.9 0.0 1.0100 -0.9 -0.9 0.0
Decreased103204276 0 103204276 7.6 4.9 -2.7 -6.415.6 -0.3 -0.9 -0.6
Decreased103204260 16 103204276 3.3 2.9 -0.4 -1.374.2 -1.2 -1.3 -0.1
Decreased1032042697103204276 1.3 -1.2 -2.5 -2.5NA -1.7 -2.2 -0.5
Decreased10320426115103204276 0.5 -0.4 -0.9 -1.5NA -1.8 -2.0 -0.2
Sites found for donor



IVS4nt1g>a


Instruction: c103204186t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Decreased103204168 18 103204186 4.4 4.2 -0.2 -1.286.5 -1.0 -1.0 -0.0
No Change 103204138 48103204186 2.0 2.0 0.0 1.0100 -1.5 -1.5 0.0
Sites found for donor
No Change 103204171 15103204186 2.0 2.0 0.0 1.0100 -1.8 -1.8 0.0
Decreased1032041860103204186 6.8 -6.0 -12.8 -109.9NA -0.4 -4.3 -3.9



IVS4nt-1g>a


Instruction: c103193389t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Decreased103193389 0 103193389 10.8 3.3 -7.6 -191.10.5 0.4 -1.2 -1.7
Increased 103193388 1103193389 1.5 9.6 8.2 286.228616.6 -1.6 0.2 1.8
Decreased103193379 10 103193389 4.9 4.4 -0.4 -1.473.8 -0.9 -1.0 -0.1
increased1031933872103193389 -1.5 0.2 1.7 1.2118.8 -2.3 -1.9 0.4
Sites found for donor
No Change 103193406 -17103193389 5.1 5.1 0.0 1.0100 -0.9 -0.9 0.0



IVS4nt-5c>g


Instruction: g103193393c ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103193421 -32103193389 1.6 1.6 0.0 1.0100 -1.6 -1.6 0.0
Decreased103193389 0 103193389 10.8 8.3 -2.5 -5.717.4 0.4 -0.1 -0.6
Decreased103193379 10 103193389 4.9 3.6 -1.3 -2.540.5 -0.9 -1.2 -0.3
Decreased1031933881103193389 1.5 -1.2 -2.7 -2.8NA -1.6 -2.2 -0.6
Sites found for donor
No Change 103193443 -54103193389 4.4 4.4 0.0 1.0100 -1.1 -1.1 0.0
No Change 103193406 -17103193389 5.1 5.1 0.0 1.0100 -0.9 -0.9 0.0



IVS5nt1delg


Instruction: d103193320,103193320 ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Increased 103193298 22103193320 2.6 2.7 0.0 1.0103.2 -1.4 -1.3 0.0
Decreased1031933200103193320 0.4 -13.3 -13.7 -1.4NA -1.8 -4.8 -3.0
Sites found for donor
No Change 103193296 24103193320 0.9 0.9 0.0 1.0100 -2.2 -2.2 0.0
Decreased1031933200103193320 7.4 -7.5 -15.0 -173.8NA -0.2 -4.7 -4.5



IVS5nt1g>a


Instruction: c103193320t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Increased 103193298 22103193320 2.6 3.1 0.4 1.4135.5 -1.4 -1.3 0.1
Decreased1031933200103193320 0.4 -7.1 -7.6 -1.4NA -1.8 -3.5 -1.7
Sites found for donor
No Change 103193296 24103193320 0.9 0.9 0.0 1.0100 -2.2 -2.2 0.0
Decreased1031933200103193320 7.4 -5.4 -12.8 -173.8NA -0.2 -4.1 -3.9



IVS5nt5delg


Instruction: d103193316,103193316 ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103193320 0103193320 0.4 0.4 0.0 1.0100 -1.8 -1.8 0.0
Decreased103193298 22 103193320 2.6 2.3 -0.4 -1.377.4 -1.4 -1.4 -0.1
Sites found for donor
Decreased103193320 0 103193320 7.4 1.8 -5.7 -50.41.9 -0.2 -1.9 -1.7
No Change 103193296 24103193320 0.9 0.9 0.0 1.0100 -2.2 -2.2 0.0



IVS5nt54c>g


Instruction: g103193267c ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Decreased103193250 70 103193320 1.8 0.5 -1.3 -2.540.3 -1.5 -1.8 -0.3
Decreased103193246 74 103193320 11.0 10.0 -1.0 -2.148.5 0.5 0.2 -0.2
No Change 103193241 79103193320 3.0 3.0 0.0 1.0100 -1.3 -1.3 0.0
Decreased10319325763103193320 0.6 -1.1 -1.7 -1.5NA -1.8 -2.2 -0.4
Decreased10319324377103193320 0.3 -0.7 -1.0 -1.2NA -1.9 -2.1 -0.2
Sites found for donor
No Change 103193296 24103193320 0.9 0.9 0.0 1.0100 -2.2 -2.2 0.0
No Change 103193245 75103193320 3.3 3.3 0.0 1.0100 -1.4 -1.4 0.0



IVS6nt-1g>a


Instruction: c103179676t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103179681 -5103179676 5.4 5.4 0.0 1.0100 -0.7 -0.7 0.0
Decreased103179676 0 103179676 14.7 7.1 -7.6 -191.10.5 1.3 -0.4 -1.7
No Change 103179669 7103179676 2.2 2.2 0.0 1.0100 -1.5 -1.5 0.0
Decreased103179667 9 103179676 1.9 1.5 -0.4 -1.374.8 -1.5 -1.6 -0.1
Increased 103179654 22103179676 0.6 1.1 0.4 1.4135.5 -1.8 -1.7 0.1
No Change 103179627 49103179676 2.0 2.0 0.0 1.0100 -1.5 -1.5 0.0
No Change 103179626 50103179676 2.2 2.2 0.0 1.0100 -1.5 -1.5 0.0
increased1031796751103179676 -5.1 3.0 8.2 8.2816.9 -3.1 -1.3 1.8
increased1031796724103179676 -0.2 0.1 0.3 1.0104.5 -2.0 -1.9 0.1
Sites found for donor
No Change 103179714 -38103179676 3.9 3.9 0.0 1.0100 -1.2 -1.2 0.0
No Change 103179649 27103179676 0.9 0.9 0.0 1.0100 -2.2 -2.2 0.0



IVS6nt-2a>g


Instruction: t103179677c ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103179681 -5103179676 5.4 5.4 0.0 1.0100 -0.7 -0.7 0.0
Decreased103179676 0 103179676 14.7 6.5 -8.2 -286.20.3 1.3 -0.5 -1.8
Increased 103179669 7103179676 2.2 2.5 0.3 1.2123.0 -1.5 -1.4 0.1
Increased 103179667 9103179676 1.9 2.4 0.4 1.4135.4 -1.5 -1.4 0.1
Decreased103179654 22 103179676 0.6 0.3 -0.3 -1.280.5 -1.8 -1.9 -0.1
No Change 103179627 49103179676 2.0 2.0 0.0 1.0100 -1.5 -1.5 0.0
No Change 103179626 50103179676 2.2 2.2 0.0 1.0100 -1.5 -1.5 0.0
increased103179677-1103179676 -0.5 7.0 7.6 130.813079.4 -2.1 -0.4 1.7
Sites found for donor
No Change 103179714 -38103179676 3.9 3.9 0.0 1.0100 -1.2 -1.2 0.0
No Change 103179649 27103179676 0.9 0.9 0.0 1.0100 -2.2 -2.2 0.0



IVS7nt1g>a


Instruction: c103179539t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Increased 103179522 17103179539 4.9 5.0 0.1 1.1109.8 -0.9 -0.8 0.0
Increased 103179515 24103179539 4.0 4.4 0.4 1.3130.5 -1.1 -1.0 0.1
No Change 103179508 31103179539 3.7 3.7 0.0 1.0100 -1.1 -1.1 0.0
Sites found for donor
No Change 103179581 -42103179539 0.7 0.7 0.0 1.0100 -2.2 -2.2 0.0
No Change 103179554 -15103179539 1.2 1.2 0.0 1.0100 -2.1 -2.1 0.0
Decreased1031795390103179539 6.1 -6.7 -12.8 -68.8NA -0.6 -4.5 -3.9



IVS7nt2t>a


Instruction: a103179538t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Decreased103179522 17 103179539 4.9 3.5 -1.4 -2.737.3 -0.9 -1.2 -0.3
Decreased103179515 24 103179539 4.0 3.4 -0.6 -1.664.3 -1.1 -1.2 -0.1
No Change 103179508 31103179539 3.7 3.7 0.0 1.0100 -1.1 -1.1 0.0
Sites found for donor
No Change 103179581 -42103179539 0.7 0.7 0.0 1.0100 -2.2 -2.2 0.0
No Change 103179554 -15103179539 1.2 1.2 0.0 1.0100 -2.1 -2.1 0.0
Decreased1031795390103179539 6.1 -1.7 -7.8 -68.8NA -0.6 -2.9 -2.4



IVS7nt5g>a


Instruction: c103179535t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Decreased103179522 17 103179539 4.9 4.4 -0.5 -1.568.5 -0.9 -1.0 -0.1
Increased 103179515 24103179539 4.0 4.3 0.3 1.2122.1 -1.1 -1.0 0.1
No Change 103179508 31103179539 3.7 3.7 0.0 1.0100 -1.1 -1.1 0.0
Sites found for donor
No Change 103179581 -42103179539 0.7 0.7 0.0 1.0100 -2.2 -2.2 0.0
No Change 103179554 -15103179539 1.2 1.2 0.0 1.0100 -2.1 -2.1 0.0
Decreased103179539 0 103179539 6.1 2.6 -3.5 -11.58.7 -0.6 -1.6 -1.1



IVS7nt-2a>t


Instruction: t103178483a ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103178508 -26103178482 0.9 0.9 0.0 1.0100 -1.7 -1.7 0.0
No Change 103178506 -24103178482 4.5 4.5 0.0 1.0100 -1.0 -1.0 0.0
No Change 103178490 -8103178482 1.0 1.0 0.0 1.0100 -1.7 -1.7 0.0
Decreased103178482 0 103178482 10.8 3.4 -7.4 -171.70.5 0.4 -1.2 -1.6
No Change 103178438 44103178482 7.2 7.2 0.0 1.0100 -0.4 -0.4 0.0
No Change 103178431 51103178482 7.0 7.0 0.0 1.0100 -0.4 -0.4 0.0
increased1031784766103178482 -1.5 0.4 2.0 1.3134.0 -2.3 -1.8 0.4
Sites found for donor
No Change 103178453 29103178482 0.1 0.1 0.0 1.0100 -2.4 -2.4 0.0



IVS8nt1g>a


Instruction: c103178411t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103178438 -27103178411 7.2 7.2 0.0 1.0100 -0.4 -0.4 0.0
No Change 103178431 -20103178411 7.0 7.0 0.0 1.0100 -0.4 -0.4 0.0
No Change 103178421 -10103178411 2.5 2.5 0.0 1.0100 -1.4 -1.4 0.0
Decreased103178412 -1 103178411 9.4 8.4 -1.0 -1.951.5 0.1 -0.1 -0.2
Increased 103178407 4103178411 1.4 1.7 0.3 1.2123.3 -1.6 -1.6 0.1
No Change 103178384 27103178411 5.1 5.1 0.0 1.0100 -0.8 -0.8 0.0
No Change 103178378 33103178411 8.4 8.4 0.0 1.0100 -0.1 -0.1 0.0
Sites found for donor
No Change 103178453 -42103178411 0.1 0.1 0.0 1.0100 -2.4 -2.4 0.0
No Change 103178406 5103178411 0.5 0.5 0.0 1.0100 -2.3 -2.3 0.0
No Change 103178377 34103178411 3.6 3.6 0.0 1.0100 -1.3 -1.3 0.0
Decreased1031784110103178411 11.5 -1.3 -12.8 -2922.7NA 1.1 -2.8 -3.9



IVS8nt-5t>g


Instruction: a103173681c ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Decreased103173677 0 103173677 10.0 6.9 -3.1 -8.911.2 0.3 -0.4 -0.7
Decreased103173683-6103173677 0.3 -0.2 -0.5 -1.2NA -1.9 -2.0 -0.1
Sites found for donor
No Change 103173676 1103173677 1.4 1.4 0.0 1.0100 -2.0 -2.0 0.0
No Change 103173654 23103173677 0.2 0.2 0.0 1.0100 -2.4 -2.4 0.0



IVS8nt-7a>g


Instruction: t103173683c ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103173711 -34103173677 6.4 6.4 0.0 1.0100 -0.5 -0.5 0.0
Increased 103173683 -6103173677 0.3 7.9 7.6 191.119111.1 -1.9 -0.2 1.7
Decreased103173677 0 103173677 10.0 10.0 -0.1 -1.095.7 0.3 0.2 -0.0
Sites found for donor
No Change 103173676 1103173677 1.4 1.4 0.0 1.0100 -2.0 -2.0 0.0
No Change 103173654 23103173677 0.2 0.2 0.0 1.0100 -2.4 -2.4 0.0



IVS9nt6t>a


Instruction: a103173614t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Decreased103173600 19 103173619 3.5 1.5 -2.0 -3.925.5 -1.2 -1.6 -0.4
Decreased103173599 20 103173619 3.1 1.5 -1.6 -2.934.1 -1.3 -1.6 -0.3
No Change 103173564 55103173619 2.0 2.0 0.0 1.0100 -1.5 -1.5 0.0
Sites found for donor
No Change 103173654 -35103173619 0.2 0.2 0.0 1.0100 -2.4 -2.4 0.0
Decreased103173619 0 103173619 7.3 5.7 -1.6 -3.033.2 -0.2 -0.7 -0.5
No Change 103173598 21103173619 2.8 2.8 0.0 1.0100 -1.6 -1.6 0.0
No Change 103173591 28103173619 2.2 2.2 0.0 1.0100 -1.8 -1.8 0.0



IVS9nt-2a>c


Instruction: t103171158g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103171175 -18103171157 3.0 3.0 0.0 1.0100 -1.3 -1.3 0.0
Decreased103171157 0 103171157 9.6 2.2 -7.4 -171.70.5 0.2 -1.5 -1.6
Increased 103171149 8103171157 1.9 3.9 2.0 4.1407.6 -1.5 -1.1 0.4
Increased 103171136 21103171157 0.2 0.7 0.5 1.4141.7 -1.9 -1.8 0.1
Sites found for donor
No Change 103171186 -29103171157 1.8 1.8 0.0 1.0100 -1.9 -1.9 0.0
No Change 103171116 41103171157 0.2 0.2 0.0 1.0100 -2.4 -2.4 0.0



IVS9nt-5t>a


Instruction: a103171161t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103171175 -18103171157 3.0 3.0 0.0 1.0100 -1.3 -1.3 0.0
Decreased103171157 0 103171157 9.6 6.7 -2.8 -7.213.8 0.2 -0.5 -0.6
Decreased1031711498103171157 1.9 -0.6 -2.5 -3.7NA -1.5 -2.1 -0.5
Decreased10317113621103171157 0.2 -0.1 -0.3 -1.2NA -1.9 -2.0 -0.1
Sites found for donor
No Change 103171186 -29103171157 1.8 1.8 0.0 1.0100 -1.9 -1.9 0.0
No Change 103171116 41103171157 0.2 0.2 0.0 1.0100 -2.4 -2.4 0.0



IVS10nt1g>a


Instruction: c103171060t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Decreased103171061 -1 103171060 7.6 6.7 -1.0 -1.951.5 -0.3 -0.5 -0.2
Decreased103171046 14 103171060 3.8 3.5 -0.3 -1.281.8 -1.1 -1.2 -0.1
Sites found for donor
No Change 103171095 -35103171060 2.2 2.2 0.0 1.0100 -1.8 -1.8 0.0
No Change 103171071 -11103171060 4.6 4.6 0.0 1.0100 -1.0 -1.0 0.0
No Change 103171024 36103171060 1.8 1.8 0.0 1.0100 -1.9 -1.9 0.0
No Change 103171021 39103171060 6.5 6.5 0.0 1.0100 -0.5 -0.5 0.0
No Change 103171017 43103171060 1.0 1.0 0.0 1.0100 -2.1 -2.1 0.0
Decreased1031710600103171060 7.8 -5.0 -12.8 -228.6NA -0.1 -3.9 -3.9



IVS10nt3a>g


Instruction: t103171058c ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103171061 -1103171060 7.6 7.6 0.0 1.0100 -0.3 -0.3 0.0
Increased 103171046 14103171060 3.8 4.3 0.5 1.4142.6 -1.1 -1.0 0.1
Sites found for donor
No Change 103171095 -35103171060 2.2 2.2 0.0 1.0100 -1.8 -1.8 0.0
No Change 103171071 -11103171060 4.6 4.6 0.0 1.0100 -1.0 -1.0 0.0
Decreased103171060 0 103171060 7.8 7.4 -0.4 -1.375.7 -0.1 -0.2 -0.1
No Change 103171024 36103171060 1.8 1.8 0.0 1.0100 -1.9 -1.9 0.0
No Change 103171021 39103171060 6.5 6.5 0.0 1.0100 -0.5 -0.5 0.0
No Change 103171017 43103171060 1.0 1.0 0.0 1.0100 -2.1 -2.1 0.0



IVS10nt-11g>a


Instruction: c103170515t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103170535 -30103170505 1.2 1.2 0.0 1.0100 -1.7 -1.7 0.0
Decreased103170505 0 103170505 5.2 4.8 -0.4 -1.473.8 -0.8 -0.9 -0.1
Increased 103170492 13103170505 1.8 2.2 0.3 1.2124.0 -1.5 -1.5 0.1
No Change 103170466 39103170505 2.1 2.1 0.0 1.0100 -1.5 -1.5 0.0
increased103170514-9103170505 -5.5 2.7 8.2 6.4636.3 -3.1 -1.4 1.8
Sites found for donor
No Change 103170535 -30103170505 1.6 1.6 0.0 1.0100 -2.0 -2.0 0.0



IVS10nt-3c>t


Instruction: g103170507a ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103170535 -30103170505 1.2 1.2 0.0 1.0100 -1.7 -1.7 0.0
Decreased103170505 0 103170505 5.2 3.6 -1.7 -3.231.6 -0.8 -1.2 -0.4
Increased 103170492 13103170505 1.8 2.1 0.2 1.2116.1 -1.5 -1.5 0.0
No Change 103170466 39103170505 2.1 2.1 0.0 1.0100 -1.5 -1.5 0.0
No Change 103170460 45103170505 0.4 0.4 0.0 1.0100 -1.8 -1.8 0.0
Sites found for donor
No Change 103170535 -30103170505 1.6 1.6 0.0 1.0100 -2.0 -2.0 0.0



IVS11nt1g>a


Instruction: c103170370t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Sites found for donor
Decreased103170375 -5 103170370 7.8 7.4 -0.4 -1.377.5 -0.1 -0.2 -0.1
No Change 103170365 5103170370 3.5 3.5 0.0 1.0100 -1.4 -1.4 0.0
No Change 103170362 8103170370 3.5 3.5 0.0 1.0100 -1.4 -1.4 0.0
No Change 103170353 17103170370 10.5 10.5 0.0 1.0100 0.8 0.8 0.0
Decreased1031703700103170370 10.4 -2.4 -12.8 -1372.3NA 0.7 -3.2 -3.9



IVS11nt1g>c


Instruction: c103170370g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Sites found for donor
Decreased103170375 -5 103170370 7.8 7.6 -0.2 -1.187.3 -0.1 -0.1 -0.1
Decreased103170370 0 103170370 10.4 0.6 -9.8 -894.50.1 0.7 -2.2 -3.0
No Change 103170365 5103170370 3.5 3.5 0.0 1.0100 -1.4 -1.4 0.0
No Change 103170362 8103170370 3.5 3.5 0.0 1.0100 -1.4 -1.4 0.0
No Change 103170353 17103170370 10.5 10.5 0.0 1.0100 0.8 0.8 0.0



IVS11nt20g>c


Instruction: c103170351g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Sites found for donor
No Change 103170375 -5103170370 7.8 7.8 0.0 1.0100 -0.1 -0.1 0.0
No Change 103170370 0103170370 10.4 10.4 0.0 1.0100 0.7 0.7 0.0
No Change 103170365 5103170370 3.5 3.5 0.0 1.0100 -1.4 -1.4 0.0
No Change 103170362 8103170370 3.5 3.5 0.0 1.0100 -1.4 -1.4 0.0
Decreased103170353 17 103170370 10.5 6.1 -4.4 -21.14.7 0.8 -0.6 -1.3
No Change 103170321 49103170370 1.4 1.4 0.0 1.0100 -2.0 -2.0 0.0
No Change 103170308 62103170370 3.2 3.2 0.0 1.0100 -1.5 -1.5 0.0
No Change 103170304 66103170370 2.4 2.4 0.0 1.0100 -1.7 -1.7 0.0



IVS11nt-8g>a


Instruction: c103167248t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103167260 -19103167241 3.2 3.2 0.0 1.0100 -1.2 -1.2 0.0
No Change 103167241 0103167241 6.4 6.4 0.0 1.0100 -0.5 -0.5 0.0
No Change 103167206 35103167241 6.9 6.9 0.0 1.0100 -0.4 -0.4 0.0
increased103167247-6103167241 -5.6 2.6 8.2 6.1608.5 -3.2 -1.4 1.8
Sites found for donor
No Change 103167275 -34103167241 1.1 1.1 0.0 1.0100 -2.1 -2.1 0.0



IVS12nt2t>c


Instruction: a103167123g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Increased 103167124 0103167124 3.2 3.5 0.3 1.2123.5 -1.2 -1.2 0.1
No Change 103167085 39103167124 4.3 4.3 0.0 1.0100 -1.0 -1.0 0.0
No Change 103167076 48103167124 0.3 0.3 0.0 1.0100 -1.9 -1.9 0.0
Sites found for donor
Decreased103167124 0 103167124 7.5 0.0 -7.5 -177.50.5 -0.2 -2.4 -2.3
Increased 103167120 4103167124 3.6 5.2 1.6 3.0303.1 -1.3 -0.8 0.5
No Change 103167085 39103167124 1.1 1.1 0.0 1.0100 -2.1 -2.1 0.0



IVS12nt-5t>c


Instruction: a103165948g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103165976 -32103165944 1.4 1.4 0.0 1.0100 -1.6 -1.6 0.0
Decreased103165944 0 103165944 12.5 11.9 -0.6 -1.564.5 0.8 0.7 -0.1
No Change 103165922 22103165944 0.5 0.5 0.0 1.0100 -1.8 -1.8 0.0
No Change 103165912 32103165944 7.2 7.2 0.0 1.0100 -0.4 -0.4 0.0
Sites found for donor
No Change 103165975 -31103165944 1.1 1.1 0.0 1.0100 -2.1 -2.1 0.0
No Change 103165959 -15103165944 2.5 2.5 0.0 1.0100 -1.7 -1.7 0.0
Decreased103165947 -3 103165944 3.5 2.8 -0.7 -1.760.2 -1.4 -1.6 -0.2
No Change 103165943 1103165944 5.1 5.1 0.0 1.0100 -0.9 -0.9 0.0
No Change 103165903 41103165944 4.6 4.6 0.0 1.0100 -1.0 -1.0 0.0



IVS12nt-35c>t


Instruction: g103165978a ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 103166007 -63103165944 2.4 2.4 0.0 1.0100 -1.4 -1.4 0.0
No Change 103165944 0103165944 12.5 12.5 0.0 1.0100 0.8 0.8 0.0
Decreased103165976-32103165944 1.4 -0.3 -1.7 -2.6NA -1.6 -2.0 -0.4
Sites found for donor
No Change 103165959 -15103165944 2.5 2.5 0.0 1.0100 -1.7 -1.7 0.0
No Change 103165947 -3103165944 3.5 3.5 0.0 1.0100 -1.4 -1.4 0.0
No Change 103165943 1103165944 5.1 5.1 0.0 1.0100 -0.9 -0.9 0.0
Decreased103165975-31103165944 1.1 -0.5 -1.6 -2.2NA -2.1 -2.6 -0.5