Gene: PAH
mRNA Accession: U49897
Mutation:PAH.txt
Chromosome: chr 12

Sequence Walker  


Decrease of Information Content
Mutation SubmittedMutation InstructionGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
IVS2nt19t>c
Sequence Walker
a103239497g 103239476 39 103239515 0.9 0.9 -0.1 -1.0 96.1 -1.7 -1.7 -0.0
IVS3nt-6t>a
Sequence Walker
a103204281t 103204276 0 103204276 7.6 4.9 -2.7 -6.4 15.6 -0.3 -0.9 -0.6
IVS3nt-6t>a
Sequence Walker
a103204281t 103204260 16 103204276 3.3 2.9 -0.4 -1.3 74.2 -1.2 -1.3 -0.1
IVS3nt-6t>a
Sequence Walker  
a103204281t 103204269 7 103204276 1.3 -1.2 -2.5 -2.5 NA -1.7 -2.2 -0.5
IVS3nt-6t>a
Sequence Walker  
a103204281t 103204261 15 103204276 0.5 -0.4 -0.9 -1.5 NA -1.8 -2.0 -0.2
IVS4nt1g>a
Sequence Walker
c103204186t 103204168 18 103204186 4.4 4.2 -0.2 -1.2 86.5 -1.0 -1.0 -0.0
IVS4nt-1g>a
Sequence Walker
c103193389t 103193389 0 103193389 10.8 3.3 -7.6 -191.1 0.5 0.4 -1.2 -1.7
IVS4nt-1g>a
Sequence Walker
c103193389t 103193379 10 103193389 4.9 4.4 -0.4 -1.4 73.8 -0.9 -1.0 -0.1
IVS4nt-5c>g
Sequence Walker
g103193393c 103193389 0 103193389 10.8 8.3 -2.5 -5.7 17.4 0.4 -0.1 -0.6
IVS4nt-5c>g
Sequence Walker
g103193393c 103193379 10 103193389 4.9 3.6 -1.3 -2.5 40.5 -0.9 -1.2 -0.3
IVS4nt-5c>g
Sequence Walker  
g103193393c 103193388 1 103193389 1.5 -1.2 -2.7 -2.8 NA -1.6 -2.2 -0.6
IVS5nt1delg
Sequence Walker  
d103193320,103193320 103193320 0 103193320 0.4 -13.3 -13.7 -1.4 NA -1.8 -4.8 -3.0
IVS5nt1g>a
Sequence Walker  
c103193320t 103193320 0 103193320 0.4 -7.1 -7.6 -1.4 NA -1.8 -3.5 -1.7
IVS5nt5delg
Sequence Walker
d103193316,103193316 103193298 22 103193320 2.6 2.3 -0.4 -1.3 77.4 -1.4 -1.4 -0.1
IVS5nt54c>g
Sequence Walker
g103193267c 103193250 70 103193320 1.8 0.5 -1.3 -2.5 40.3 -1.5 -1.8 -0.3
IVS5nt54c>g
Sequence Walker
g103193267c 103193246 74 103193320 11.0 10.0 -1.0 -2.1 48.5 0.5 0.2 -0.2
IVS5nt54c>g
Sequence Walker  
g103193267c 103193257 63 103193320 0.6 -1.1 -1.7 -1.5 NA -1.8 -2.2 -0.4
IVS5nt54c>g
Sequence Walker  
g103193267c 103193243 77 103193320 0.3 -0.7 -1.0 -1.2 NA -1.9 -2.1 -0.2
IVS6nt-1g>a
Sequence Walker
c103179676t 103179676 0 103179676 14.7 7.1 -7.6 -191.1 0.5 1.3 -0.4 -1.7
IVS6nt-1g>a
Sequence Walker
c103179676t 103179667 9 103179676 1.9 1.5 -0.4 -1.3 74.8 -1.5 -1.6 -0.1
IVS6nt-2a>g
Sequence Walker
t103179677c 103179676 0 103179676 14.7 6.5 -8.2 -286.2 0.3 1.3 -0.5 -1.8
IVS6nt-2a>g
Sequence Walker
t103179677c 103179654 22 103179676 0.6 0.3 -0.3 -1.2 80.5 -1.8 -1.9 -0.1
IVS7nt2t>a
Sequence Walker
a103179538t 103179522 17 103179539 4.9 3.5 -1.4 -2.7 37.3 -0.9 -1.2 -0.3
IVS7nt2t>a
Sequence Walker
a103179538t 103179515 24 103179539 4.0 3.4 -0.6 -1.6 64.3 -1.1 -1.2 -0.1
IVS7nt5g>a
Sequence Walker
c103179535t 103179522 17 103179539 4.9 4.4 -0.5 -1.5 68.5 -0.9 -1.0 -0.1
IVS7nt-2a>t
Sequence Walker
t103178483a 103178482 0 103178482 10.8 3.4 -7.4 -171.7 0.5 0.4 -1.2 -1.6
IVS8nt1g>a
Sequence Walker
c103178411t 103178412 -1 103178411 9.4 8.4 -1.0 -1.9 51.5 0.1 -0.1 -0.2
IVS8nt-5t>g
Sequence Walker
a103173681c 103173677 0 103173677 10.0 6.9 -3.1 -8.9 11.2 0.3 -0.4 -0.7
IVS8nt-5t>g
Sequence Walker  
a103173681c 103173683 -6 103173677 0.3 -0.2 -0.5 -1.2 NA -1.9 -2.0 -0.1
IVS8nt-7a>g
Sequence Walker
t103173683c 103173677 0 103173677 10.0 10.0 -0.1 -1.0 95.7 0.3 0.2 -0.0
IVS9nt6t>a
Sequence Walker
a103173614t 103173600 19 103173619 3.5 1.5 -2.0 -3.9 25.5 -1.2 -1.6 -0.4
IVS9nt6t>a
Sequence Walker
a103173614t 103173599 20 103173619 3.1 1.5 -1.6 -2.9 34.1 -1.3 -1.6 -0.3
IVS9nt-2a>c
Sequence Walker
t103171158g 103171157 0 103171157 9.6 2.2 -7.4 -171.7 0.5 0.2 -1.5 -1.6
IVS9nt-5t>a
Sequence Walker
a103171161t 103171157 0 103171157 9.6 6.7 -2.8 -7.2 13.8 0.2 -0.5 -0.6
IVS9nt-5t>a
Sequence Walker  
a103171161t 103171149 8 103171157 1.9 -0.6 -2.5 -3.7 NA -1.5 -2.1 -0.5
IVS9nt-5t>a
Sequence Walker  
a103171161t 103171136 21 103171157 0.2 -0.1 -0.3 -1.2 NA -1.9 -2.0 -0.1
IVS10nt1g>a
Sequence Walker
c103171060t 103171061 -1 103171060 7.6 6.7 -1.0 -1.9 51.5 -0.3 -0.5 -0.2
IVS10nt1g>a
Sequence Walker
c103171060t 103171046 14 103171060 3.8 3.5 -0.3 -1.2 81.8 -1.1 -1.2 -0.1
IVS10nt-11g>a
Sequence Walker
c103170515t 103170505 0 103170505 5.2 4.8 -0.4 -1.4 73.8 -0.8 -0.9 -0.1
IVS10nt-3c>t
Sequence Walker
g103170507a 103170505 0 103170505 5.2 3.6 -1.7 -3.2 31.6 -0.8 -1.2 -0.4
IVS12nt-5t>c
Sequence Walker
a103165948g 103165944 0 103165944 12.5 11.9 -0.6 -1.5 64.5 0.8 0.7 -0.1
IVS12nt-35c>t
Sequence Walker  
g103165978a 103165976 -32 103165944 1.4 -0.3 -1.7 -2.6 NA -1.6 -2.0 -0.4