Gene: LIS1
mRNA Accession: L13386
Mutation:LIS1.txt
Chromosome: chr 17

Sequence Walker  




1018-1019insT


Instruction: i2533249,2533250t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2533207 -1060 2534267 1.0 1.0 0.0 1.0 100 -2.1 -2.1 0.0
No change 2533240 -1027 2534267 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
No change 2533257 -1010 2534267 5.5 5.5 0.0 1.0 100 -0.8 -0.8 0.0
No change 2533288 -979 2534267 6.8 6.8 0.0 1.0 100 -0.4 -0.4 0.0
No change 2533292 -975 2534267 1.9 1.9 0.0 1.0 100 -1.9 -1.9 0.0



1050-1051insG

Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z )Δ Z
Increased newly inserted = 2533218 -1049 2534267 0.0 3.1 3.1 8.4 842.3 0.0 -1.5 -1.5
No change 2533207 -1060 2534267 1.0 1.0 0.0 1.0 100 -2.1 -2.1 0.0
No change 2533240 -1027 2534267 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
No change 2533257 -1010 2534267 5.5 5.5 0.0 1.0 100 -0.8 -0.8 0.0



1188C>T


Instruction: c2535861t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2535883 51 2535832 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0
No change 2535889 57 2535832 5.2 5.2 0.0 1.0 100 -0.9 -0.9 0.0
No change 2535891 59 2535832 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0



154-155insA


Instruction: i2519965,2519966a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2519942 -177 2520119 6.8 6.8 0.0 1.0 100 -0.4 -0.4 0.0
No change 2519969 -150 2520119 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
No change 2519984 -135 2520119 10.7 10.7 0.0 1.0 100 0.8 0.8 0.0



162-163insA


Instruction: i2519957,2519958a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2519908 -211 2520119 0.7 0.7 0.0 1.0 100 -2.2 -2.2 0.0
No change 2519942 -177 2520119 6.8 6.8 0.0 1.0 100 -0.4 -0.4 0.0
No change 2519969 -150 2520119 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
No change 2519984 -135 2520119 10.7 10.7 0.0 1.0 100 0.8 0.8 0.0



162delA


Instruction: d2520164,2520164; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2520140 -55 2520195 4.5 4.5 0.0 1.0 100 -1.1 -1.1 0.0
No change 2520195 0 2520195 8.6 8.6 0.0 1.0 100 0.2 0.2 0.0



166delA


Instruction: d2520168,2520168; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2520140 -55 2520195 4.5 4.5 0.0 1.0 100 -1.1 -1.1 0.0
No change 2520195 0 2520195 8.6 8.6 0.0 1.0 100 0.2 0.2 0.0



265C>T


Instruction: c2521168t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2521143 48 2521095 0.5 0.5 0.0 1.0 100 -2.3 -2.3 0.0
No change 2521148 53 2521095 4.6 4.6 0.0 1.0 100 -1.0 -1.0 0.0
No change 2521160 65 2521095 2.6 2.6 0.0 1.0 100 -1.6 -1.6 0.0



430C>T


Instruction: c2524297t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2524267 1 2524266 8.4 8.4 0.0 1.0 100 0.1 0.1 0.0
No change 2524269 3 2524266 0.9 0.9 0.0 1.0 100 -2.2 -2.2 0.0



446A>G


Instruction: a2524313g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2524267 1 2524266 8.4 8.4 0.0 1.0 100 0.1 0.1 0.0
No change 2524269 3 2524266 0.9 0.9 0.0 1.0 100 -2.2 -2.2 0.0
No change 2524352 86 2524266 0.1 0.1 0.0 1.0 100 -2.4 -2.4 0.0



484G>A

Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z )Δ Z
Decreased 2524352 -84 2524436 0.1 -2.9 -3.1 -1.1 NA -2.4 -3.3 -0.9



499T>C


Instruction: t2524366c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2524352 -84 2524436 0.1 0.1 0.0 1.0 100 -2.4 -2.4 0.0



687A>T


Instruction: a2528179t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2528140 -23 2528163 6.4 6.4 0.0 1.0 100 -0.5 -0.5 0.0
No change 2528169 6 2528163 2.2 2.2 0.0 1.0 100 -1.8 -1.8 0.0
No change 2528171 8 2528163 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0
No change 2528201 38 2528163 5.8 5.8 0.0 1.0 100 -0.7 -0.7 0.0
No change 2528205 42 2528163 2.2 2.2 0.0 1.0 100 -1.8 -1.8 0.0
No change 2528210 47 2528163 6.0 6.0 0.0 1.0 100 -0.6 -0.6 0.0



703-704delGA


Instruction: d2527460,2527461; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2527420 -743 2528163 4.9 4.9 0.0 1.0 100 -1.0 -1.0 0.0
No change 2527431 -732 2528163 2.3 2.3 0.0 1.0 100 -1.7 -1.7 0.0
No change 2527447 -716 2528163 0.9 0.9 0.0 1.0 100 -2.2 -2.2 0.0
No change 2527449 -714 2528163 3.5 3.5 0.0 1.0 100 -1.4 -1.4 0.0
No change 2527473 -690 2528163 2.4 2.4 0.0 1.0 100 -1.7 -1.7 0.0
No change 2527486 -677 2528163 1.8 1.8 0.0 1.0 100 -1.9 -1.9 0.0



771-772delTG


Instruction: d2527392,2527393; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2527348 -815 2528163 5.9 5.9 0.0 1.0 100 -0.6 -0.6 0.0
No change 2527353 -810 2528163 2.6 2.6 0.0 1.0 100 -1.6 -1.6 0.0
No change 2527420 -743 2528163 4.9 4.9 0.0 1.0 100 -1.0 -1.0 0.0
No change 2527431 -732 2528163 2.3 2.3 0.0 1.0 100 -1.7 -1.7 0.0
Decreased 2527386 -777 2528163 0.8 -0.1 -0.9 -1.7 NA -2.2 -2.5 -0.3
Increased 2527391 -772 2528163 -12.9 0.3 13.2 1.2 123.8 -6.4 -2.3 4.0



805delA


Instruction: d2528297,2528297; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2528264 -129 2528393 4.2 4.2 0.0 1.0 100 -1.2 -1.2 0.0
No change 2528270 -123 2528393 3.2 3.2 0.0 1.0 100 -1.5 -1.5 0.0
No change 2528291 -102 2528393 0.3 0.3 0.0 1.0 100 -2.4 -2.4 0.0
No change 2528324 -69 2528393 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
No change 2528327 -66 2528393 1.2 1.2 0.0 1.0 100 -2.1 -2.1 0.0
Decreased 2528295 -98 2528393 0.4 -2.7 -3.1 -1.3 NA -2.3 -3.3 -0.9



817C>T


Instruction: c2528309t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2528264 -129 2528393 4.2 4.2 0.0 1.0 100 -1.2 -1.2 0.0
No change 2528270 -123 2528393 3.2 3.2 0.0 1.0 100 -1.5 -1.5 0.0
No change 2528291 -102 2528393 0.3 0.3 0.0 1.0 100 -2.4 -2.4 0.0
No change 2528295 -98 2528393 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0
No change 2528324 -69 2528393 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
No change 2528327 -66 2528393 1.2 1.2 0.0 1.0 100 -2.1 -2.1 0.0



866C>G


Instruction: c2528358g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2528324 -69 2528393 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
No change 2528327 -66 2528393 1.2 1.2 0.0 1.0 100 -2.1 -2.1 0.0
No change 2528393 0 2528393 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0
No change 2528398 5 2528393 0.6 0.6 0.0 1.0 100 -2.2 -2.2 0.0



881-882delCT


Instruction: d2527282,2527283; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2527233 -930 2528163 1.8 1.8 0.0 1.0 100 -1.9 -1.9 0.0



903-904insT


Instruction: i2529705,2529706t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2529665 -943 2530608 0.6 0.6 0.0 1.0 100 -2.3 -2.3 0.0
No change 2529675 -933 2530608 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0



92T>C


Instruction: t2519535c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2519561 0 2519561 5.8 5.8 0.0 1.0 100 -0.7 -0.7 0.0



949G>C


Instruction: g2530657c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2530619 11 2530608 1.0 1.0 0.0 1.0 100 -2.1 -2.1 0.0
No change 2530622 14 2530608 4.3 4.3 0.0 1.0 100 -1.1 -1.1 0.0
No change 2530674 66 2530608 3.2 3.2 0.0 1.0 100 -1.5 -1.5 0.0
No change 2530681 73 2530608 3.5 3.5 0.0 1.0 100 -1.4 -1.4 0.0
No change 2530691 83 2530608 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0
No change 2530695 87 2530608 1.5 1.5 0.0 1.0 100 -2.0 -2.0 0.0



c.1002+1G>A


Instruction: g2530711a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2530674 -37 2530711 3.2 3.2 0.0 1.0 100 -1.5 -1.5 0.0
No change 2530681 -30 2530711 3.5 3.5 0.0 1.0 100 -1.4 -1.4 0.0
No change 2530691 -20 2530711 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0
No change 2530695 -16 2530711 1.5 1.5 0.0 1.0 100 -2.0 -2.0 0.0
Decreased 2530711 0 2530711 6.0 -6.8 -12.8 -65.6 NA -0.6 -4.5 -3.9



c.1002+5G>A


Instruction: g2530715a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2530674 -37 2530711 3.2 3.2 0.0 1.0 100 -1.5 -1.5 0.0
No change 2530681 -30 2530711 3.5 3.5 0.0 1.0 100 -1.4 -1.4 0.0
No change 2530691 -20 2530711 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0
No change 2530695 -16 2530711 1.5 1.5 0.0 1.0 100 -2.0 -2.0 0.0
Decreased 2530711 0 2530711 6.0 2.5 -3.5 -11.5 8.7 -0.6 -1.7 -1.1



c.1159+3insCA


Instruction: i2492395,2492396ca; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2492348 -77 2492425 0.0 0.0 0.0 1.0 100 -2.4 -2.4 0.0
No change 2492425 0 2492425 6.7 6.7 0.0 1.0 100 -0.4 -0.4 0.0
Decreased 2492396 -29 2492425 1.3 -12.6 -13.9 -2.5 NA -2.0 -6.3 -4.2



c.569-10T>C


Instruction: t2526749c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2526717 -41 2526758 0.0 0.0 0.0 1.0 100 -2.4 -2.4 0.0
No change 2526720 -38 2526758 2.3 2.3 0.0 1.0 100 -1.7 -1.7 0.0
Increased 2526746 -12 2526758 0.1 0.1 0.0 1.0 102.0 -2.4 -2.4 0.0



c.900+1G>A


Instruction: g2528393a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2528398 5 2528393 0.6 0.6 0.0 1.0 100 -2.2 -2.2 0.0
Decreased 2528393 0 2528393 2.8 -10.0 -12.8 -7.1 NA -1.6 -5.5 -3.9

Legend:    Site Abolished   Leaky Site   Cryptic Site created   Strengthened Pre-existing site   Pre-existing Site   Weakened Pre-existing Site