Gene: LIS1
mRNA Accession: L13386
Mutation:LIS1.txt
Chromosome: chr 17

Sequence Walker  


No Change of Information Content
Mutation SubmittedMutation InstructionGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
1018-1019insT
Sequence Walker  
i2533249,2533250t 2533207 -1060 2534267 1.0 1.0 0.0 1.0 100 -2.1 -2.1 0.0
1018-1019insT
Sequence Walker  
i2533249,2533250t 2533240 -1027 2534267 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
1018-1019insT
Sequence Walker  
i2533249,2533250t 2533257 -1010 2534267 5.5 5.5 0.0 1.0 100 -0.8 -0.8 0.0
1018-1019insT
Sequence Walker  
i2533249,2533250t 2533288 -979 2534267 6.8 6.8 0.0 1.0 100 -0.4 -0.4 0.0
1018-1019insT
Sequence Walker  
i2533249,2533250t 2533292 -975 2534267 1.9 1.9 0.0 1.0 100 -1.9 -1.9 0.0
1050-1051insG
Sequence Walker  
i2533217,2533218g 2533207 -1060 2534267 1.0 1.0 0.0 1.0 100 -2.1 -2.1 0.0
1050-1051insG
Sequence Walker  
i2533217,2533218g 2533240 -1027 2534267 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
1050-1051insG
Sequence Walker  
i2533217,2533218g 2533257 -1010 2534267 5.5 5.5 0.0 1.0 100 -0.8 -0.8 0.0
1188C>T
Sequence Walker  
c2535861t 2535883 51 2535832 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0
1188C>T
Sequence Walker  
c2535861t 2535889 57 2535832 5.2 5.2 0.0 1.0 100 -0.9 -0.9 0.0
1188C>T
Sequence Walker  
c2535861t 2535891 59 2535832 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0
154-155insA
Sequence Walker  
i2519965,2519966a 2519942 -177 2520119 6.8 6.8 0.0 1.0 100 -0.4 -0.4 0.0
154-155insA
Sequence Walker  
i2519965,2519966a 2519969 -150 2520119 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
154-155insA
Sequence Walker  
i2519965,2519966a 2519984 -135 2520119 10.7 10.7 0.0 1.0 100 0.8 0.8 0.0
162-163insA
Sequence Walker  
i2519957,2519958a 2519908 -211 2520119 0.7 0.7 0.0 1.0 100 -2.2 -2.2 0.0
162-163insA
Sequence Walker  
i2519957,2519958a 2519942 -177 2520119 6.8 6.8 0.0 1.0 100 -0.4 -0.4 0.0
162-163insA
Sequence Walker  
i2519957,2519958a 2519969 -150 2520119 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
162-163insA
Sequence Walker  
i2519957,2519958a 2519984 -135 2520119 10.7 10.7 0.0 1.0 100 0.8 0.8 0.0
162delA
Sequence Walker  
d2520164,2520164 2520140 -55 2520195 4.5 4.5 0.0 1.0 100 -1.1 -1.1 0.0
162delA
Sequence Walker  
d2520164,2520164 2520195 0 2520195 8.6 8.6 0.0 1.0 100 0.2 0.2 0.0
166delA
Sequence Walker  
d2520168,2520168 2520140 -55 2520195 4.5 4.5 0.0 1.0 100 -1.1 -1.1 0.0
166delA
Sequence Walker  
d2520168,2520168 2520195 0 2520195 8.6 8.6 0.0 1.0 100 0.2 0.2 0.0
265C>T
Sequence Walker  
c2521168t 2521143 48 2521095 0.5 0.5 0.0 1.0 100 -2.3 -2.3 0.0
265C>T
Sequence Walker  
c2521168t 2521148 53 2521095 4.6 4.6 0.0 1.0 100 -1.0 -1.0 0.0
265C>T
Sequence Walker  
c2521168t 2521160 65 2521095 2.6 2.6 0.0 1.0 100 -1.6 -1.6 0.0
430C>T
Sequence Walker  
c2524297t 2524267 1 2524266 8.4 8.4 0.0 1.0 100 0.1 0.1 0.0
430C>T
Sequence Walker  
c2524297t 2524269 3 2524266 0.9 0.9 0.0 1.0 100 -2.2 -2.2 0.0
446A>G
Sequence Walker  
a2524313g 2524267 1 2524266 8.4 8.4 0.0 1.0 100 0.1 0.1 0.0
446A>G
Sequence Walker  
a2524313g 2524269 3 2524266 0.9 0.9 0.0 1.0 100 -2.2 -2.2 0.0
446A>G
Sequence Walker  
a2524313g 2524352 86 2524266 0.1 0.1 0.0 1.0 100 -2.4 -2.4 0.0
499T>C
Sequence Walker  
t2524366c 2524352 -84 2524436 0.1 0.1 0.0 1.0 100 -2.4 -2.4 0.0
687A>T
Sequence Walker  
a2528179t 2528140 -23 2528163 6.4 6.4 0.0 1.0 100 -0.5 -0.5 0.0
687A>T
Sequence Walker  
a2528179t 2528169 6 2528163 2.2 2.2 0.0 1.0 100 -1.8 -1.8 0.0
687A>T
Sequence Walker  
a2528179t 2528171 8 2528163 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0
687A>T
Sequence Walker  
a2528179t 2528201 38 2528163 5.8 5.8 0.0 1.0 100 -0.7 -0.7 0.0
687A>T
Sequence Walker  
a2528179t 2528205 42 2528163 2.2 2.2 0.0 1.0 100 -1.8 -1.8 0.0
687A>T
Sequence Walker  
a2528179t 2528210 47 2528163 6.0 6.0 0.0 1.0 100 -0.6 -0.6 0.0
703-704delGA
Sequence Walker  
d2527460,2527461 2527420 -743 2528163 4.9 4.9 0.0 1.0 100 -1.0 -1.0 0.0
703-704delGA
Sequence Walker  
d2527460,2527461 2527431 -732 2528163 2.3 2.3 0.0 1.0 100 -1.7 -1.7 0.0
703-704delGA
Sequence Walker  
d2527460,2527461 2527447 -716 2528163 0.9 0.9 0.0 1.0 100 -2.2 -2.2 0.0
703-704delGA
Sequence Walker  
d2527460,2527461 2527449 -714 2528163 3.5 3.5 0.0 1.0 100 -1.4 -1.4 0.0
703-704delGA
Sequence Walker  
d2527460,2527461 2527473 -690 2528163 2.4 2.4 0.0 1.0 100 -1.7 -1.7 0.0
703-704delGA
Sequence Walker  
d2527460,2527461 2527486 -677 2528163 1.8 1.8 0.0 1.0 100 -1.9 -1.9 0.0
771-772delTG
Sequence Walker  
d2527392,2527393 2527348 -815 2528163 5.9 5.9 0.0 1.0 100 -0.6 -0.6 0.0
771-772delTG
Sequence Walker  
d2527392,2527393 2527353 -810 2528163 2.6 2.6 0.0 1.0 100 -1.6 -1.6 0.0
771-772delTG
Sequence Walker  
d2527392,2527393 2527420 -743 2528163 4.9 4.9 0.0 1.0 100 -1.0 -1.0 0.0
771-772delTG
Sequence Walker  
d2527392,2527393 2527431 -732 2528163 2.3 2.3 0.0 1.0 100 -1.7 -1.7 0.0
805delA
Sequence Walker  
d2528297,2528297 2528264 -129 2528393 4.2 4.2 0.0 1.0 100 -1.2 -1.2 0.0
805delA
Sequence Walker  
d2528297,2528297 2528270 -123 2528393 3.2 3.2 0.0 1.0 100 -1.5 -1.5 0.0
805delA
Sequence Walker  
d2528297,2528297 2528291 -102 2528393 0.3 0.3 0.0 1.0 100 -2.4 -2.4 0.0
805delA
Sequence Walker  
d2528297,2528297 2528324 -69 2528393 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
805delA
Sequence Walker  
d2528297,2528297 2528327 -66 2528393 1.2 1.2 0.0 1.0 100 -2.1 -2.1 0.0
817C>T
Sequence Walker  
c2528309t 2528264 -129 2528393 4.2 4.2 0.0 1.0 100 -1.2 -1.2 0.0
817C>T
Sequence Walker  
c2528309t 2528270 -123 2528393 3.2 3.2 0.0 1.0 100 -1.5 -1.5 0.0
817C>T
Sequence Walker  
c2528309t 2528291 -102 2528393 0.3 0.3 0.0 1.0 100 -2.4 -2.4 0.0
817C>T
Sequence Walker  
c2528309t 2528295 -98 2528393 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0
817C>T
Sequence Walker  
c2528309t 2528324 -69 2528393 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
817C>T
Sequence Walker  
c2528309t 2528327 -66 2528393 1.2 1.2 0.0 1.0 100 -2.1 -2.1 0.0
866C>G
Sequence Walker  
c2528358g 2528324 -69 2528393 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
866C>G
Sequence Walker  
c2528358g 2528327 -66 2528393 1.2 1.2 0.0 1.0 100 -2.1 -2.1 0.0
866C>G
Sequence Walker  
c2528358g 2528393 0 2528393 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0
866C>G
Sequence Walker  
c2528358g 2528398 5 2528393 0.6 0.6 0.0 1.0 100 -2.2 -2.2 0.0
881-882delCT
Sequence Walker  
d2527282,2527283 2527233 -930 2528163 1.8 1.8 0.0 1.0 100 -1.9 -1.9 0.0
903-904insT
Sequence Walker  
i2529705,2529706t 2529665 -943 2530608 0.6 0.6 0.0 1.0 100 -2.3 -2.3 0.0
903-904insT
Sequence Walker  
i2529705,2529706t 2529675 -933 2530608 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
92T>C
Sequence Walker  
t2519535c 2519561 0 2519561 5.8 5.8 0.0 1.0 100 -0.7 -0.7 0.0
949G>C
Sequence Walker  
g2530657c 2530619 11 2530608 1.0 1.0 0.0 1.0 100 -2.1 -2.1 0.0
949G>C
Sequence Walker  
g2530657c 2530622 14 2530608 4.3 4.3 0.0 1.0 100 -1.1 -1.1 0.0
949G>C
Sequence Walker  
g2530657c 2530674 66 2530608 3.2 3.2 0.0 1.0 100 -1.5 -1.5 0.0
949G>C
Sequence Walker  
g2530657c 2530681 73 2530608 3.5 3.5 0.0 1.0 100 -1.4 -1.4 0.0
949G>C
Sequence Walker  
g2530657c 2530691 83 2530608 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0
949G>C
Sequence Walker  
g2530657c 2530695 87 2530608 1.5 1.5 0.0 1.0 100 -2.0 -2.0 0.0
c.1002+1G>A
Sequence Walker  
g2530711a 2530674 -37 2530711 3.2 3.2 0.0 1.0 100 -1.5 -1.5 0.0
c.1002+1G>A
Sequence Walker  
g2530711a 2530681 -30 2530711 3.5 3.5 0.0 1.0 100 -1.4 -1.4 0.0
c.1002+1G>A
Sequence Walker  
g2530711a 2530691 -20 2530711 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0
c.1002+1G>A
Sequence Walker  
g2530711a 2530695 -16 2530711 1.5 1.5 0.0 1.0 100 -2.0 -2.0 0.0
c.1002+5G>A
Sequence Walker  
g2530715a 2530674 -37 2530711 3.2 3.2 0.0 1.0 100 -1.5 -1.5 0.0
c.1002+5G>A
Sequence Walker  
g2530715a 2530681 -30 2530711 3.5 3.5 0.0 1.0 100 -1.4 -1.4 0.0
c.1002+5G>A
Sequence Walker  
g2530715a 2530691 -20 2530711 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0
c.1002+5G>A
Sequence Walker  
g2530715a 2530695 -16 2530711 1.5 1.5 0.0 1.0 100 -2.0 -2.0 0.0
c.1159+3insCA
Sequence Walker  
i2492395,2492396ca 2492348 -77 2492425 0.0 0.0 0.0 1.0 100 -2.4 -2.4 0.0
c.1159+3insCA
Sequence Walker  
i2492395,2492396ca 2492425 0 2492425 6.7 6.7 0.0 1.0 100 -0.4 -0.4 0.0
c.569-10T>C
Sequence Walker  
t2526749c 2526717 -41 2526758 0.0 0.0 0.0 1.0 100 -2.4 -2.4 0.0
c.569-10T>C
Sequence Walker  
t2526749c 2526720 -38 2526758 2.3 2.3 0.0 1.0 100 -1.7 -1.7 0.0
c.900+1G>A
Sequence Walker  
g2528393a 2528398 5 2528393 0.6 0.6 0.0 1.0 100 -2.2 -2.2 0.0