Gene: LIS1
mRNA Accession: L13386
Mutation:LIS1.txt
Chromosome: chr 17

Sequence Walker  




1018-1019insT


Instruction: i2533249,2533250t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 2533256 -1011 2534267 2.6 3.6 1.1 2.1 207.1 -1.4 -1.1 0.2
Increased 2533268 -999 2534267 1.8 2.4 0.5 1.5 146.2 -1.5 -1.4 0.1
Increased 2533260 -1007 2534267 -0.7 0.6 1.3 1.5 153.9 -2.1 -1.8 0.3



1050-1051insG


Instruction: i2533217,2533218g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2533206 -1061 2534267 0.1 0.1 0.0 1.0 100 -1.9 -1.9 0.0
No change 2533212 -1055 2534267 8.9 8.9 0.0 1.0 100 0.0 0.0 0.0
No change 2533256 -1011 2534267 2.6 2.6 0.0 1.0 100 -1.4 -1.4 0.0
No change 2533268 -999 2534267 1.8 1.8 0.0 1.0 100 -1.5 -1.5 0.0



1188C>T


Instruction: c2535861t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2535832 0 2535832 14.4 14.4 0.0 1.0 100 1.2 1.2 0.0
No change 2535840 8 2535832 4.6 4.6 0.0 1.0 100 -0.9 -0.9 0.0
No change 2535842 10 2535832 4.2 4.2 0.0 1.0 100 -1.0 -1.0 0.0
No change 2535843 11 2535832 3.9 3.9 0.0 1.0 100 -1.1 -1.1 0.0
Increased 2535869 37 2535832 3.5 3.8 0.3 1.2 124.6 -1.2 -1.1 0.1
Increased 2535874 42 2535832 1.9 2.4 0.4 1.3 134.9 -1.5 -1.4 0.1



154-155insA


Instruction: i2519965,2519966a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2519941 -178 2520119 2.3 2.3 0.0 1.0 100 -1.4 -1.4 0.0
No change 2519959 -160 2520119 1.7 1.7 0.0 1.0 100 -1.6 -1.6 0.0
Decreased 2519969 -150 2520119 2.8 2.3 -0.5 -1.4 69.8 -1.3 -1.4 -0.1
Decreased 2519983 -136 2520119 2.6 2.0 -0.6 -1.5 65.6 -1.4 -1.5 -0.1
Decreased 2519967 -152 2520119 0.3 0.3 0.0 1.0 103.1 -1.9 -1.9 0.0
Increased 2519966 -153 2520119 -7.5 0.3 7.8 1.3 125.3 -3.6 -1.9 1.7



162-163insA


Instruction: i2519957,2519958a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2519934 -185 2520119 3.0 3.0 0.0 1.0 100 -1.3 -1.3 0.0
No change 2519941 -178 2520119 2.3 2.3 0.0 1.0 100 -1.4 -1.4 0.0
Decreased 2519959 -160 2520119 1.7 1.6 -0.1 -1.1 91.7 -1.6 -1.6 -0.0
Decreased 2519969 -150 2520119 2.8 2.0 -0.9 -1.8 54.6 -1.3 -1.5 -0.2
No change 2519983 -136 2520119 2.6 2.6 0.0 1.0 100 -1.4 -1.4 0.0
Decreased 2519967 -152 2520119 0.3 -8.9 -9.1 -1.2 NA -1.9 -3.9 -2.0



166delA


Instruction: d2520168,2520168; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2520217 22 2520195 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0
No change 2520219 24 2520195 0.0 0.0 0.0 1.0 100 -1.9 -1.9 0.0



265C>T


Instruction: c2521168t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2521164 69 2521095 0.3 0.3 0.0 1.0 100 -1.9 -1.9 0.0
No change 2521201 106 2521095 3.2 3.2 0.0 1.0 100 -1.2 -1.2 0.0



430C>T


Instruction: c2524297t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2524329 63 2524266 0.7 0.7 0.0 1.0 100 -1.8 -1.8 0.0
No change 2524349 83 2524266 3.5 3.5 0.0 1.0 100 -1.2 -1.2 0.0



446A>G


Instruction: a2524313g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 2524329 63 2524266 0.7 0.8 0.0 1.0 103.1 -1.8 -1.8 0.0
No change 2524349 83 2524266 3.5 3.5 0.0 1.0 100 -1.2 -1.2 0.0



484G>A


Instruction: g2524351a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2524329 -107 2524436 0.7 0.7 0.0 1.0 100 -1.8 -1.8 0.0
Increased 2524349 -87 2524436 3.5 3.6 0.0 1.0 103.1 -1.2 -1.2 0.0
No change 2524378 -58 2524436 11.8 11.8 0.0 1.0 100 0.6 0.6 0.0
Increased 2524352 -84 2524436 -6.3 1.9 8.2 3.6 364.3 -3.3 -1.5 1.8



499T>C


Instruction: t2524366c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2524349 -87 2524436 3.5 3.5 0.0 1.0 100 -1.2 -1.2 0.0
Decreased 2524378 -58 2524436 11.8 11.4 -0.4 -1.3 75.9 0.6 0.6 -0.1
No change 2524407 -29 2524436 2.6 2.6 0.0 1.0 100 -1.4 -1.4 0.0



687A>T


Instruction: a2528179t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2528163 0 2528163 3.5 3.5 0.0 1.0 100 -1.2 -1.2 0.0
Increased 2528186 23 2528163 0.6 2.5 2.0 3.9 391.8 -1.8 -1.4 0.4



703-704delGA


Instruction: d2527460,2527461; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2527434 -729 2528163 1.7 1.7 0.0 1.0 100 -1.6 -1.6 0.0
No change 2527495 -668 2528163 2.5 2.5 0.0 1.0 100 -1.4 -1.4 0.0



771-772delTG


Instruction: d2527392,2527393; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2527419 -744 2528163 11.8 11.8 0.0 1.0 100 0.6 0.6 0.0
No change 2527434 -729 2528163 1.7 1.7 0.0 1.0 100 -1.6 -1.6 0.0



817C>T


Instruction: c2528309t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2528351 -42 2528393 4.2 4.2 0.0 1.0 100 -1.0 -1.0 0.0



866C>G


Instruction: c2528358g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2528351 -42 2528393 4.2 4.2 0.0 1.0 100 -1.0 -1.0 0.0
Decreased 2528378 -15 2528393 5.6 4.6 -1.0 -2.0 49.2 -0.7 -0.9 -0.2
No change 2528384 -9 2528393 4.7 4.7 0.0 1.0 100 -0.9 -0.9 0.0
Decreased 2528375 -18 2528393 0.2 -1.1 -1.3 -1.1 NA -1.9 -2.2 -0.3



881-882delCT


Instruction: d2527282,2527283; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2527332 -831 2528163 1.7 1.7 0.0 1.0 100 -1.6 -1.6 0.0



903-904insT


Instruction: i2529705,2529706t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2529733 -875 2530608 5.6 5.6 0.0 1.0 100 -0.7 -0.7 0.0
No change 2529755 -853 2530608 4.8 4.8 0.0 1.0 100 -0.9 -0.9 0.0
No change 2529756 -852 2530608 3.4 3.4 0.0 1.0 100 -1.2 -1.2 0.0
No change 2529757 -851 2530608 2.6 2.6 0.0 1.0 100 -1.4 -1.4 0.0



92T>C


Instruction: t2519535c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2519580 19 2519561 0.7 0.7 0.0 1.0 100 -1.8 -1.8 0.0
No change 2519587 26 2519561 3.1 3.1 0.0 1.0 100 -1.3 -1.3 0.0



949G>C


Instruction: g2530657c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 2530655 47 2530608 4.4 4.0 -0.4 -1.3 74.5 -1.0 -1.1 -0.1
Decreased 2530657 49 2530608 0.9 -6.4 -7.3 -1.8 NA -1.8 -3.3 -1.6



c.1002+1G>A


Instruction: g2530711a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2530744 33 2530711 2.7 2.7 0.0 1.0 100 -1.3 -1.3 0.0
No change 2530750 39 2530711 4.3 4.3 0.0 1.0 100 -1.0 -1.0 0.0
No change 2530752 41 2530711 3.6 3.6 0.0 1.0 100 -1.1 -1.1 0.0
No change 2530759 48 2530711 1.3 1.3 0.0 1.0 100 -1.6 -1.6 0.0



c.1002+5G>A


Instruction: g2530715a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2530744 33 2530711 2.7 2.7 0.0 1.0 100 -1.3 -1.3 0.0
No change 2530750 39 2530711 4.3 4.3 0.0 1.0 100 -1.0 -1.0 0.0
No change 2530752 41 2530711 3.6 3.6 0.0 1.0 100 -1.1 -1.1 0.0
No change 2530759 48 2530711 1.3 1.3 0.0 1.0 100 -1.6 -1.6 0.0
No change 2530766 55 2530711 1.7 1.7 0.0 1.0 100 -1.6 -1.6 0.0
No change 2530767 56 2530711 1.5 1.5 0.0 1.0 100 -1.6 -1.6 0.0



c.1159+3insCA


Instruction: i2492395,2492396ca; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2492387 -38 2492425 1.8 1.8 0.0 1.0 100 -1.6 -1.6 0.0
Decreased 2492407 -18 2492425 1.8 0.9 -0.9 -1.8 54.7 -1.6 -1.7 -0.2



c.569-10T>C


Instruction: t2526749c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 2526758 0 2526758 5.9 5.3 -0.6 -1.5 66.7 -0.6 -0.8 -0.1
No change 2526782 24 2526758 3.0 3.0 0.0 1.0 100 -1.3 -1.3 0.0
No change 2526785 27 2526758 3.6 3.6 0.0 1.0 100 -1.2 -1.2 0.0



c.900+1G>A


Instruction: g2528393a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 2528375 -18 2528393 0.2 0.2 0.0 1.0 100 -1.9 -1.9 0.0
No change 2528378 -15 2528393 5.6 5.6 0.0 1.0 100 -0.7 -0.7 0.0
No change 2528384 -9 2528393 4.7 4.7 0.0 1.0 100 -0.9 -0.9 0.0
No change 2528430 37 2528393 1.6 1.6 0.0 1.0 100 -1.6 -1.6 0.0
No change 2528440 47 2528393 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0

Legend:    Site Abolished   Leaky Site   Cryptic Site created   Strengthened Pre-existing site   Pre-existing Site   Weakened Pre-existing Site