Gene: LIS1
mRNA Accession: L13386
Mutation:LIS1.txt
Chromosome: chr 17

Sequence Walker  


Decrease of Information Content
Mutation SubmittedMutation InstructionGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
154-155insA
Sequence Walker
i2519965,2519966a 2519969 -150 2520119 2.8 2.3 -0.5 -1.4 69.8 -1.3 -1.4 -0.1
154-155insA
Sequence Walker
i2519965,2519966a 2519983 -136 2520119 2.6 2.0 -0.6 -1.5 65.6 -1.4 -1.5 -0.1
154-155insA
Sequence Walker  
i2519965,2519966a 2519967 -152 2520119 0.3 0.3 0.0 1.0 103.1 -1.9 -1.9 0.0
162-163insA
Sequence Walker
i2519957,2519958a 2519959 -160 2520119 1.7 1.6 -0.1 -1.1 91.7 -1.6 -1.6 -0.0
162-163insA
Sequence Walker
i2519957,2519958a 2519969 -150 2520119 2.8 2.0 -0.9 -1.8 54.6 -1.3 -1.5 -0.2
162-163insA
Sequence Walker  
i2519957,2519958a 2519967 -152 2520119 0.3 -8.9 -9.1 -1.2 NA -1.9 -3.9 -2.0
499T>C
Sequence Walker
t2524366c 2524378 -58 2524436 11.8 11.4 -0.4 -1.3 75.9 0.6 0.6 -0.1
866C>G
Sequence Walker
c2528358g 2528378 -15 2528393 5.6 4.6 -1.0 -2.0 49.2 -0.7 -0.9 -0.2
866C>G
Sequence Walker  
c2528358g 2528375 -18 2528393 0.2 -1.1 -1.3 -1.1 NA -1.9 -2.2 -0.3
949G>C
Sequence Walker
g2530657c 2530655 47 2530608 4.4 4.0 -0.4 -1.3 74.5 -1.0 -1.1 -0.1
949G>C
Sequence Walker  
g2530657c 2530657 49 2530608 0.9 -6.4 -7.3 -1.8 NA -1.8 -3.3 -1.6
c.1159+3insCA
Sequence Walker
i2492395,2492396ca 2492407 -18 2492425 1.8 0.9 -0.9 -1.8 54.7 -1.6 -1.7 -0.2
c.569-10T>C
Sequence Walker
t2526749c 2526758 0 2526758 5.9 5.3 -0.6 -1.5 66.7 -0.6 -0.8 -0.1