Gene: DTD
mRNA Accession: U14528
Mutation:DTD.txt
Chromosome: chr 5

Sequence Walker  




1045-1047delGTT

Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z )Δ Z
Decreased 149341965 -1048 149343013 1.8 -6.2 -8.0 -3.6 NA -1.9 -4.3 -2.4



1184C>T


Instruction: c149343498t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149343456 443 149343013 2.6 2.6 0.0 1.0 100 -1.6 -1.6 0.0
No change 149343458 445 149343013 0.5 0.5 0.0 1.0 100 -2.3 -2.3 0.0
No change 149343464 451 149343013 0.5 0.5 0.0 1.0 100 -2.3 -2.3 0.0
No change 149343540 527 149343013 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0



1221delA


Instruction: d149343535,149343535; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149343540 527 149343013 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0
No change 149343568 555 149343013 4.5 4.5 0.0 1.0 100 -1.1 -1.1 0.0



1269-1272delAAAC


Instruction: d149341742,149341745; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149341702 -1311 149343013 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0



1421delT


Instruction: d149343735,149343735; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149343684 671 149343013 5.4 5.4 0.0 1.0 100 -0.8 -0.8 0.0
No change 149343689 676 149343013 4.3 4.3 0.0 1.0 100 -1.1 -1.1 0.0
No change 149343722 709 149343013 2.4 2.4 0.0 1.0 100 -1.7 -1.7 0.0
No change 149343756 743 149343013 0.1 0.1 0.0 1.0 100 -2.4 -2.4 0.0
No change 149343765 752 149343013 3.4 3.4 0.0 1.0 100 -1.4 -1.4 0.0
No change 149343767 754 149343013 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0
No change 149343779 766 149343013 3.4 3.4 0.0 1.0 100 -1.4 -1.4 0.0



1478G>A


Instruction: g149343792a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149343756 743 149343013 0.1 0.1 0.0 1.0 100 -2.4 -2.4 0.0
No change 149343765 752 149343013 3.4 3.4 0.0 1.0 100 -1.4 -1.4 0.0
No change 149343767 754 149343013 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0
No change 149343779 766 149343013 3.4 3.4 0.0 1.0 100 -1.4 -1.4 0.0
Increased 149343790 777 149343013 0.3 0.7 0.4 1.3 131.9 -2.3 -2.2 0.1
No change 149343801 788 149343013 0.9 0.9 0.0 1.0 100 -2.2 -2.2 0.0
No change 149343826 813 149343013 1.0 1.0 0.0 1.0 100 -2.1 -2.1 0.0



1501C>T


Instruction: c149343815t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149343765 752 149343013 3.4 3.4 0.0 1.0 100 -1.4 -1.4 0.0
No change 149343767 754 149343013 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0
No change 149343779 766 149343013 3.4 3.4 0.0 1.0 100 -1.4 -1.4 0.0
No change 149343790 777 149343013 0.3 0.3 0.0 1.0 100 -2.3 -2.3 0.0
No change 149343801 788 149343013 0.9 0.9 0.0 1.0 100 -2.2 -2.2 0.0
No change 149343826 813 149343013 1.0 1.0 0.0 1.0 100 -2.1 -2.1 0.0
No change 149343859 846 149343013 2.5 2.5 0.0 1.0 100 -1.7 -1.7 0.0



1677delG


Instruction: d149343991,149343991; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149343983 970 149343013 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
No change 149343998 985 149343013 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0



2021A>C


Instruction: a149344335c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149344382 -738 149345120 6.0 6.0 0.0 1.0 100 -0.6 -0.6 0.0



418delT


Instruction: d149340791,149340791; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149340837 -236 149341073 1.6 1.6 0.0 1.0 100 -1.9 -1.9 0.0
Decreased 149340792 -281 149341073 2.6 -17.6 -20.2 -5.9 NA -1.7 -7.8 -6.1



422T>C


Instruction: t149340795c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 149340792 -281 149341073 2.6 2.6 0.0 1.0 102.0 -1.7 -1.6 0.0
No change 149340837 -236 149341073 1.6 1.6 0.0 1.0 100 -1.9 -1.9 0.0



476delT


Instruction: d149340849,149340849; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149340837 -236 149341073 1.6 1.6 0.0 1.0 100 -1.9 -1.9 0.0
No change 149340857 -216 149341073 1.4 1.4 0.0 1.0 100 -2.0 -2.0 0.0
No change 149340891 -182 149341073 6.8 6.8 0.0 1.0 100 -0.4 -0.4 0.0



558C>T


Instruction: c149340931t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149340891 -182 149341073 6.8 6.8 0.0 1.0 100 -0.4 -0.4 0.0



731-737delGATGGGC


Instruction: d149342277,149342283; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149342243 -770 149343013 1.0 1.0 0.0 1.0 100 -2.1 -2.1 0.0
Increased 149342284 -729 149343013 2.6 4.0 1.3 2.5 252.9 -1.6 -1.2 0.4
Decreased 149342280 -733 149343013 1.2 -22.6 -23.7 -2.3 NA -2.1 -9.3 -7.2



74C>G


Instruction: c149340447g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149340480 134 149340346 1.5 1.5 0.0 1.0 100 -2.0 -2.0 0.0
Increased 149340447 101 149340346 -5.5 4.3 9.8 20.1 2013.8 -4.1 -1.1 3.0



933-934delCT


Instruction: d149342080,149342081; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149342045 -968 149343013 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0
No change 149342057 -956 149343013 1.6 1.6 0.0 1.0 100 -1.9 -1.9 0.0
No change 149342060 -953 149343013 0.0 0.0 0.0 1.0 100 -2.4 -2.4 0.0
No change 149342066 -947 149343013 2.5 2.5 0.0 1.0 100 -1.7 -1.7 0.0
No change 149342070 -943 149343013 2.1 2.1 0.0 1.0 100 -1.8 -1.8 0.0
Decreased 149342079 -934 149343013 5.4 5.3 -0.1 -1.0 96.0 -0.8 -0.8 -0.0
No change 149342112 -901 149343013 6.9 6.9 0.0 1.0 100 -0.3 -0.3 0.0
Decreased 149342081 -932 149343013 0.8 -7.5 -8.3 -1.8 NA -2.2 -4.7 -2.5



IVS1+2T>C


Instruction: t149341074c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149341034 -39 149341073 2.0 2.0 0.0 1.0 100 -1.8 -1.8 0.0
No change 149341046 -27 149341073 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
Decreased 149341073 0 149341073 11.3 3.8 -7.5 -177.5 0.5 1.0 -1.3 -2.3
No change 149341095 22 149341073 0.1 0.1 0.0 1.0 100 -2.4 -2.4 0.0
No change 149341110 37 149341073 3.7 3.7 0.0 1.0 100 -1.3 -1.3 0.0
No change 149341118 45 149341073 1.4 1.4 0.0 1.0 100 -2.0 -2.0 0.0

Legend:    Site Abolished   Leaky Site   Cryptic Site created   Strengthened Pre-existing site   Pre-existing Site   Weakened Pre-existing Site