Gene: DTD
mRNA Accession: U14528
Mutation:DTD.txt
Chromosome: chr 5

Sequence Walker  




1045-1047delGTT


Instruction: d149341967,149341969; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149341962 -1051 149343013 8.5 8.5 0.0 1.0 100 -0.1 -0.1 0.0
No change 149341997 -1016 149343013 6.0 6.0 0.0 1.0 100 -0.6 -0.6 0.0



1184C>T


Instruction: c149343498t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 149343506 493 149343013 0.8 1.2 0.3 1.2 124.6 -1.8 -1.7 0.1
Increased 149343518 505 149343013 0.7 0.9 0.2 1.1 111.8 -1.8 -1.8 0.0
Decreased 149343520 507 149343013 2.5 2.5 -0.0 -1.0 96.5 -1.4 -1.4 -0.0
No change 149343532 519 149343013 0.5 0.5 0.0 1.0 100 -1.8 -1.8 0.0



1221delA


Instruction: d149343535,149343535; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149343506 493 149343013 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0
No change 149343518 505 149343013 0.7 0.7 0.0 1.0 100 -1.8 -1.8 0.0
No change 149343520 507 149343013 2.5 2.5 0.0 1.0 100 -1.4 -1.4 0.0
No change 149343532 519 149343013 0.5 0.5 0.0 1.0 100 -1.8 -1.8 0.0



1269-1272delAAAC


Instruction: d149341742,149341745; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 149341767 -1246 149343013 1.1 1.3 0.2 1.2 117.8 -1.7 -1.7 0.1
Decreased 149341770 -1243 149343013 0.4 0.1 -0.3 -1.2 80.0 -1.8 -1.9 -0.1



1421delT


Instruction: d149343735,149343735; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149343712 699 149343013 0.9 0.9 0.0 1.0 100 -1.7 -1.7 0.0
No change 149343722 709 149343013 8.1 8.1 0.0 1.0 100 -0.2 -0.2 0.0
No change 149343728 715 149343013 4.8 4.8 0.0 1.0 100 -0.9 -0.9 0.0
Decreased 149343751 738 149343013 5.5 5.0 -0.4 -1.3 74.3 -0.7 -0.8 -0.1
Decreased 149343752 739 149343013 1.9 1.5 -0.3 -1.3 79.3 -1.5 -1.6 -0.1
Decreased 149343753 740 149343013 1.2 0.5 -0.7 -1.6 60.9 -1.7 -1.8 -0.2
Decreased 149343756 743 149343013 2.0 1.9 -0.1 -1.1 91.0 -1.5 -1.5 -0.0



1478G>A


Instruction: g149343792a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 149343810 797 149343013 0.7 0.5 -0.2 -1.2 86.5 -1.8 -1.8 -0.0



1501C>T


Instruction: c149343815t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149343810 797 149343013 0.7 0.7 0.0 1.0 100 -1.8 -1.8 0.0



1677delG


Instruction: d149343991,149343991; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149344023 1010 149343013 1.6 1.6 0.0 1.0 100 -1.6 -1.6 0.0
No change 149344024 1011 149343013 3.5 3.5 0.0 1.0 100 -1.2 -1.2 0.0
No change 149344033 1020 149343013 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0



1751delA


Instruction: d149344065,149344065; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 149344081 1068 149343013 0.5 0.3 -0.2 -1.2 86.5 -1.8 -1.9 -0.0
Increased 149344083 1070 149343013 1.4 1.8 0.4 1.3 130.8 -1.6 -1.5 0.1
Decreased 149344067 1054 149343013 5.3 -12.7 -18.0 -39.7 NA -0.8 -4.7 -3.9
Decreased 149344078 1065 149343013 0.3 -11.3 -11.5 -1.2 NA -1.9 -4.4 -2.5



2003delT


Instruction: d149344317,149344317; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149344292 -828 149345120 1.8 1.8 0.0 1.0 100 -1.5 -1.5 0.0
No change 149344298 -822 149345120 2.8 2.8 0.0 1.0 100 -1.3 -1.3 0.0
No change 149344301 -819 149345120 3.7 3.7 0.0 1.0 100 -1.1 -1.1 0.0
No change 149344369 -751 149345120 1.9 1.9 0.0 1.0 100 -1.5 -1.5 0.0



2010delA


Instruction: d149344324,149344324; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149344298 -822 149345120 2.8 2.8 0.0 1.0 100 -1.3 -1.3 0.0
No change 149344301 -819 149345120 3.7 3.7 0.0 1.0 100 -1.1 -1.1 0.0
No change 149344369 -751 149345120 1.9 1.9 0.0 1.0 100 -1.5 -1.5 0.0



2021A>C


Instruction: a149344335c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149344369 -751 149345120 1.9 1.9 0.0 1.0 100 -1.5 -1.5 0.0
Increased 149344354 -766 149345120 -0.5 0.1 0.6 1.1 106.7 -2.0 -1.9 0.1



256A>C


Instruction: a149340629c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149340656 310 149340346 1.1 1.1 0.0 1.0 100 -1.7 -1.7 0.0
No change 149340661 315 149340346 0.1 0.1 0.0 1.0 100 -1.9 -1.9 0.0
No change 149340664 318 149340346 12.1 12.1 0.0 1.0 100 0.7 0.7 0.0



282delC


Instruction: d149340655,149340655; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 149340664 318 149340346 12.1 11.4 -0.7 -1.7 59.8 0.7 0.5 -0.2
Decreased 149340656 310 149340346 1.1 -8.4 -9.5 -2.2 NA -1.7 -3.8 -2.1
Decreased 149340661 315 149340346 0.1 -6.4 -6.5 -1.1 NA -1.9 -3.3 -1.4



418delT


Instruction: d149340791,149340791; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149340766 -307 149341073 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
No change 149340769 -304 149341073 4.3 4.3 0.0 1.0 100 -1.0 -1.0 0.0
No change 149340773 -300 149341073 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
No change 149340779 -294 149341073 0.7 0.7 0.0 1.0 100 -1.8 -1.8 0.0
Increased 149340816 -257 149341073 7.8 8.6 0.9 1.9 185.5 -0.2 -0.0 0.2
No change 149340819 -254 149341073 0.9 0.9 0.0 1.0 100 -1.7 -1.7 0.0
No change 149340835 -238 149341073 2.3 2.3 0.0 1.0 100 -1.4 -1.4 0.0
No change 149340836 -237 149341073 2.4 2.4 0.0 1.0 100 -1.4 -1.4 0.0



422T>C


Instruction: t149340795c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149340766 -307 149341073 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
No change 149340769 -304 149341073 4.3 4.3 0.0 1.0 100 -1.0 -1.0 0.0
No change 149340773 -300 149341073 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
No change 149340779 -294 149341073 0.7 0.7 0.0 1.0 100 -1.8 -1.8 0.0
Decreased 149340816 -257 149341073 7.8 7.7 -0.1 -1.0 96.1 -0.2 -0.3 -0.0
Increased 149340819 -254 149341073 0.9 1.0 0.1 1.1 108.2 -1.7 -1.7 0.0
No change 149340835 -238 149341073 2.3 2.3 0.0 1.0 100 -1.4 -1.4 0.0
No change 149340836 -237 149341073 2.4 2.4 0.0 1.0 100 -1.4 -1.4 0.0
No change 149340846 -227 149341073 0.5 0.5 0.0 1.0 100 -1.8 -1.8 0.0



476delT


Instruction: d149340849,149340849; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149340835 -238 149341073 2.3 2.3 0.0 1.0 100 -1.4 -1.4 0.0
No change 149340836 -237 149341073 2.4 2.4 0.0 1.0 100 -1.4 -1.4 0.0
No change 149340846 -227 149341073 0.5 0.5 0.0 1.0 100 -1.8 -1.8 0.0
Decreased 149340872 -201 149341073 0.6 0.1 -0.5 -1.4 71.4 -1.8 -1.9 -0.1
Decreased 149340850 -223 149341073 0.3 -9.6 -9.9 -1.2 NA -1.9 -4.0 -2.2
Increased 149340860 -213 149341073 -1.8 0.1 1.9 1.0 104.3 -2.3 -1.9 0.4



558C>T


Instruction: c149340931t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 149340956 -117 149341073 7.5 7.5 -0.0 -1.0 98.4 -0.3 -0.3 -0.0



731-737delGATGGGC


Instruction: d149342277,149342283; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 149342287 -726 149343013 2.6 1.1 -1.4 -2.7 36.6 -1.4 -1.7 -0.3
Increased 149342298 -715 149343013 3.2 3.9 0.7 1.6 163.9 -1.2 -1.1 0.2
Increased 149342294 -719 149343013 -1.0 0.9 1.9 1.8 184.6 -2.2 -1.7 0.4
Increased 149342297 -716 149343013 -0.7 1.5 2.3 2.9 290.1 -2.1 -1.6 0.5
Increased 149342301 -712 149343013 -0.2 0.9 1.1 1.9 185.7 -2.0 -1.7 0.2



933-934delCT


Instruction: d149342080,149342081; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149342052 -961 149343013 3.7 3.7 0.0 1.0 100 -1.1 -1.1 0.0



IVS1+2T>C


Instruction: t149341074c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 149341058 -15 149341073 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0
Decreased 149341072 -1 149341073 3.0 2.1 -0.9 -1.9 52.2 -1.3 -1.5 -0.2
No change 149341105 32 149341073 1.7 1.7 0.0 1.0 100 -1.6 -1.6 0.0

Legend:    Site Abolished   Leaky Site   Cryptic Site created   Strengthened Pre-existing site   Pre-existing Site   Weakened Pre-existing Site