Gene: DHCR7
mRNA Accession: AF034544
Mutation:DHCR7.txt
Chromosome: chr 11

Sequence Walker  




111G>A


Instruction: c71377947t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71377987 -27 71377960 2.4 2.4 0.0 1.0 100 -1.7 -1.7 0.0
No change 71377985 -25 71377960 3.0 3.0 0.0 1.0 100 -1.5 -1.5 0.0
No change 71377959 1 71377960 2.4 2.4 0.0 1.0 100 -1.7 -1.7 0.0
No change 71377955 5 71377960 3.1 3.1 0.0 1.0 100 -1.5 -1.5 0.0
No change 71377937 23 71377960 1.7 1.7 0.0 1.0 100 -1.9 -1.9 0.0



452G>A


Instruction: c71375145t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375179 6 71375185 0.8 0.8 0.0 1.0 100 -2.2 -2.2 0.0
No change 71375171 14 71375185 1.4 1.4 0.0 1.0 100 -2.0 -2.0 0.0
No change 71375123 62 71375185 1.6 1.6 0.0 1.0 100 -1.9 -1.9 0.0



682insC


Instruction: i71372771,71372772g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71372816 12 71372828 0.8 0.8 0.0 1.0 100 -2.2 -2.2 0.0
No change 71372765 63 71372828 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
No change 71372761 67 71372828 1.1 1.1 0.0 1.0 100 -2.1 -2.1 0.0
No change 71372758 70 71372828 0.1 0.1 0.0 1.0 100 -2.4 -2.4 0.0



762insT


Instruction: i71372691,71372692a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71372658 -36 71372622 3.7 3.7 0.0 1.0 100 -1.3 -1.3 0.0



IVS8-1G>C


Instruction: c71369584g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 71369582 2 71369584 2.4 2.7 0.3 1.2 120.0 -1.7 -1.6 0.1
No change 71369571 13 71369584 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0



151C>T


Instruction: g71377907a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71377955 5 71377960 3.1 3.1 0.0 1.0 100 -1.5 -1.5 0.0
No change 71377937 23 71377960 1.7 1.7 0.0 1.0 100 -1.9 -1.9 0.0
No change 71377876 84 71377960 1.5 1.5 0.0 1.0 100 -2.0 -2.0 0.0



278C>T


Instruction: g71377780a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71377776 -40 71377736 2.1 2.1 0.0 1.0 100 -1.8 -1.8 0.0
No change 71377752 -16 71377736 4.1 4.1 0.0 1.0 100 -1.2 -1.2 0.0
No change 71377736 0 71377736 6.5 6.5 0.0 1.0 100 -0.5 -0.5 0.0



296T>C


Instruction: a71377762g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71377776 -40 71377736 2.1 2.1 0.0 1.0 100 -1.8 -1.8 0.0
No change 71377752 -16 71377736 4.1 4.1 0.0 1.0 100 -1.2 -1.2 0.0
No change 71377736 0 71377736 6.5 6.5 0.0 1.0 100 -0.5 -0.5 0.0
No change 71377715 21 71377736 1.0 1.0 0.0 1.0 100 -2.1 -2.1 0.0



321G>C


Instruction: c71377737g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71377776 -40 71377736 2.1 2.1 0.0 1.0 100 -1.8 -1.8 0.0
No change 71377752 -16 71377736 4.1 4.1 0.0 1.0 100 -1.2 -1.2 0.0
Decreased 71377736 0 71377736 6.5 2.5 -4.0 -16.5 6.0 -0.5 -1.7 -1.2
No change 71377715 21 71377736 1.0 1.0 0.0 1.0 100 -2.1 -2.1 0.0
No change 71377700 36 71377736 8.5 8.5 0.0 1.0 100 0.2 0.2 0.0



326T>C


Instruction: a71376093g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71376141 -43 71376098 3.4 3.4 0.0 1.0 100 -1.4 -1.4 0.0
No change 71376130 -32 71376098 1.5 1.5 0.0 1.0 100 -2.0 -2.0 0.0
No change 71376123 -25 71376098 3.5 3.5 0.0 1.0 100 -1.4 -1.4 0.0
No change 71376108 -10 71376098 3.3 3.3 0.0 1.0 100 -1.4 -1.4 0.0
Decreased 71376097 1 71376098 5.1 5.1 -0.0 -1.0 97.9 -0.9 -0.9 -0.0



356A>T


Instruction: t71376063a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71376108 -10 71376098 3.3 3.3 0.0 1.0 100 -1.4 -1.4 0.0
No change 71376097 1 71376098 5.1 5.1 0.0 1.0 100 -0.9 -0.9 0.0
No change 71376043 55 71376098 3.3 3.3 0.0 1.0 100 -1.4 -1.4 0.0
No change 71376028 70 71376098 1.2 1.2 0.0 1.0 100 -2.1 -2.1 0.0
No change 71376019 79 71376098 0.9 0.9 0.0 1.0 100 -2.1 -2.1 0.0



440G>A


Instruction: c71375157t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375179 6 71375185 0.8 0.8 0.0 1.0 100 -2.2 -2.2 0.0
No change 71375171 14 71375185 1.4 1.4 0.0 1.0 100 -2.0 -2.0 0.0
No change 71375123 62 71375185 1.6 1.6 0.0 1.0 100 -1.9 -1.9 0.0



443T>G


Instruction: a71375154c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375179 6 71375185 0.8 0.8 0.0 1.0 100 -2.2 -2.2 0.0
No change 71375171 14 71375185 1.4 1.4 0.0 1.0 100 -2.0 -2.0 0.0
No change 71375123 62 71375185 1.6 1.6 0.0 1.0 100 -1.9 -1.9 0.0
Increased 71375153 32 71375185 -1.7 1.6 3.3 3.0 304.5 -3.0 -1.9 1.0



461C>T


Instruction: g71375136a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375179 6 71375185 0.8 0.8 0.0 1.0 100 -2.2 -2.2 0.0
No change 71375171 14 71375185 1.4 1.4 0.0 1.0 100 -2.0 -2.0 0.0
No change 71375123 62 71375185 1.6 1.6 0.0 1.0 100 -1.9 -1.9 0.0



461C>G


Instruction: g71375136c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375179 6 71375185 0.8 0.8 0.0 1.0 100 -2.2 -2.2 0.0
No change 71375171 14 71375185 1.4 1.4 0.0 1.0 100 -2.0 -2.0 0.0
No change 71375123 62 71375185 1.6 1.6 0.0 1.0 100 -1.9 -1.9 0.0



470T>C


Instruction: a71375127g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375171 14 71375185 1.4 1.4 0.0 1.0 100 -2.0 -2.0 0.0
No change 71375123 62 71375185 1.6 1.6 0.0 1.0 100 -1.9 -1.9 0.0



502T>A


Instruction: a71375095t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375123 62 71375185 1.6 1.6 0.0 1.0 100 -1.9 -1.9 0.0
No change 71375051 134 71375185 4.4 4.4 0.0 1.0 100 -1.1 -1.1 0.0



506C>T


Instruction: g71375091a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375123 62 71375185 1.6 1.6 0.0 1.0 100 -1.9 -1.9 0.0
No change 71375051 134 71375185 4.4 4.4 0.0 1.0 100 -1.1 -1.1 0.0



523G>C


Instruction: c71375074g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375123 -153 71374970 1.6 1.6 0.0 1.0 100 -1.9 -1.9 0.0
No change 71375051 -81 71374970 4.4 4.4 0.0 1.0 100 -1.1 -1.1 0.0



529T>C


Instruction: a71375068g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375051 -81 71374970 4.4 4.4 0.0 1.0 100 -1.1 -1.1 0.0



533T>A


Instruction: a71375064t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375051 -81 71374970 4.4 4.4 0.0 1.0 100 -1.1 -1.1 0.0



536C>T


Instruction: g71375061a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375051 -81 71374970 4.4 4.4 0.0 1.0 100 -1.1 -1.1 0.0



546G>C


Instruction: c71375051g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375008 -38 71374970 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
Decreased 71375051 -81 71374970 4.4 -5.5 -9.8 -20.4 NA -1.1 -4.1 -3.0



724C>T


Instruction: g71372730a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71372765 63 71372828 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
No change 71372761 67 71372828 1.1 1.1 0.0 1.0 100 -2.1 -2.1 0.0
No change 71372758 70 71372828 0.1 0.1 0.0 1.0 100 -2.4 -2.4 0.0



725G>A


Instruction: c71372729t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71372765 63 71372828 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
No change 71372761 67 71372828 1.1 1.1 0.0 1.0 100 -2.1 -2.1 0.0
No change 71372758 70 71372828 0.1 0.1 0.0 1.0 100 -2.4 -2.4 0.0



728C>G


Instruction: g71372726c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71372765 63 71372828 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
No change 71372761 67 71372828 1.1 1.1 0.0 1.0 100 -2.1 -2.1 0.0
No change 71372758 70 71372828 0.1 0.1 0.0 1.0 100 -2.4 -2.4 0.0



730G>A


Instruction: c71372724t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71372765 -143 71372622 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
No change 71372761 -139 71372622 1.1 1.1 0.0 1.0 100 -2.1 -2.1 0.0
No change 71372758 -136 71372622 0.1 0.1 0.0 1.0 100 -2.4 -2.4 0.0



740C>T


Instruction: g71372714a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71372765 -143 71372622 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
No change 71372761 -139 71372622 1.1 1.1 0.0 1.0 100 -2.1 -2.1 0.0
No change 71372758 -136 71372622 0.1 0.1 0.0 1.0 100 -2.4 -2.4 0.0



744G>T


Instruction: c71372710a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71372761 -139 71372622 1.1 1.1 0.0 1.0 100 -2.1 -2.1 0.0
No change 71372758 -136 71372622 0.1 0.1 0.0 1.0 100 -2.4 -2.4 0.0



808A>G


Instruction: t71372646c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71372658 -36 71372622 3.7 3.7 0.0 1.0 100 -1.3 -1.3 0.0
No change 71372637 -15 71372622 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
No change 71372622 0 71372622 5.7 5.7 0.0 1.0 100 -0.7 -0.7 0.0
No change 71372606 16 71372622 1.6 1.6 0.0 1.0 100 -1.9 -1.9 0.0
No change 71372600 22 71372622 4.6 4.6 0.0 1.0 100 -1.0 -1.0 0.0



841G>A


Instruction: c71371678t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71371726 -38 71371688 0.3 0.3 0.0 1.0 100 -2.3 -2.3 0.0
No change 71371715 -27 71371688 1.0 1.0 0.0 1.0 100 -2.1 -2.1 0.0
No change 71371712 -24 71371688 3.6 3.6 0.0 1.0 100 -1.3 -1.3 0.0
No change 71371649 39 71371688 4.0 4.0 0.0 1.0 100 -1.2 -1.2 0.0
Decreased 71371678 10 71371688 3.2 -9.6 -12.8 -9.0 NA -1.5 -5.4 -3.9



852C>A


Instruction: g71371667t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71371715 -27 71371688 1.0 1.0 0.0 1.0 100 -2.1 -2.1 0.0
No change 71371712 -24 71371688 3.6 3.6 0.0 1.0 100 -1.3 -1.3 0.0
No change 71371678 10 71371688 3.2 3.2 0.0 1.0 100 -1.5 -1.5 0.0
No change 71371649 39 71371688 4.0 4.0 0.0 1.0 100 -1.2 -1.2 0.0



861C>A


Instruction: g71371658t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71371678 10 71371688 3.2 3.2 0.0 1.0 100 -1.5 -1.5 0.0
No change 71371649 39 71371688 4.0 4.0 0.0 1.0 100 -1.2 -1.2 0.0
No change 71371610 78 71371688 1.8 1.8 0.0 1.0 100 -1.9 -1.9 0.0
Increased 71371661 27 71371688 -1.8 1.2 3.1 2.3 234.7 -3.0 -2.1 0.9



862G>A


Instruction: c71371657t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71371678 10 71371688 3.2 3.2 0.0 1.0 100 -1.5 -1.5 0.0
No change 71371649 39 71371688 4.0 4.0 0.0 1.0 100 -1.2 -1.2 0.0
No change 71371610 78 71371688 1.8 1.8 0.0 1.0 100 -1.9 -1.9 0.0



866C>T


Instruction: g71371653a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71371678 10 71371688 3.2 3.2 0.0 1.0 100 -1.5 -1.5 0.0
No change 71371649 39 71371688 4.0 4.0 0.0 1.0 100 -1.2 -1.2 0.0
No change 71371610 78 71371688 1.8 1.8 0.0 1.0 100 -1.9 -1.9 0.0
No change 71371607 81 71371688 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0



906C>G


Instruction: g71371613c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71371649 -94 71371555 4.0 4.0 0.0 1.0 100 -1.2 -1.2 0.0
Decreased 71371610 -55 71371555 1.8 0.6 -1.2 -2.2 44.7 -1.9 -2.3 -0.4
No change 71371607 -52 71371555 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0
No change 71371587 -32 71371555 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0



920G>A


Instruction: c71371599t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71371649 -94 71371555 4.0 4.0 0.0 1.0 100 -1.2 -1.2 0.0
No change 71371610 -55 71371555 1.8 1.8 0.0 1.0 100 -1.9 -1.9 0.0
No change 71371607 -52 71371555 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0
No change 71371587 -32 71371555 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0
No change 71371555 0 71371555 11.1 11.1 0.0 1.0 100 0.9 0.9 0.0



925G>A


Instruction: c71371594t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71371610 -55 71371555 1.8 1.8 0.0 1.0 100 -1.9 -1.9 0.0
No change 71371607 -52 71371555 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0
No change 71371587 -32 71371555 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0
No change 71371555 0 71371555 11.1 11.1 0.0 1.0 100 0.9 0.9 0.0
No change 71371547 8 71371555 7.2 7.2 0.0 1.0 100 -0.2 -0.2 0.0



931T>G


Instruction: a71371588c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71371610 -55 71371555 1.8 1.8 0.0 1.0 100 -1.9 -1.9 0.0
No change 71371607 -52 71371555 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0
Increased 71371587 -32 71371555 0.2 3.5 3.3 10.0 995.7 -2.4 -1.4 1.0
No change 71371555 0 71371555 11.1 11.1 0.0 1.0 100 0.9 0.9 0.0
No change 71371547 8 71371555 7.2 7.2 0.0 1.0 100 -0.2 -0.2 0.0



932G>A


Instruction: c71371587t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71371610 -55 71371555 1.8 1.8 0.0 1.0 100 -1.9 -1.9 0.0
No change 71371607 -52 71371555 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0
No change 71371555 0 71371555 11.1 11.1 0.0 1.0 100 0.9 0.9 0.0
No change 71371547 8 71371555 7.2 7.2 0.0 1.0 100 -0.2 -0.2 0.0
Decreased 71371587 -32 71371555 0.2 -12.6 -12.8 -1.1 NA -2.4 -6.3 -3.9



952T>A


Instruction: a71371567t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71371610 -55 71371555 1.8 1.8 0.0 1.0 100 -1.9 -1.9 0.0
No change 71371607 -52 71371555 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0
No change 71371587 -32 71371555 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0
No change 71371555 0 71371555 11.1 11.1 0.0 1.0 100 0.9 0.9 0.0
No change 71371547 8 71371555 7.2 7.2 0.0 1.0 100 -0.2 -0.2 0.0



957G>A


Instruction: c71371562t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71371610 -55 71371555 1.8 1.8 0.0 1.0 100 -1.9 -1.9 0.0
No change 71371607 -52 71371555 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0
No change 71371587 -32 71371555 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0
No change 71371555 0 71371555 11.1 11.1 0.0 1.0 100 0.9 0.9 0.0
No change 71371547 8 71371555 7.2 7.2 0.0 1.0 100 -0.2 -0.2 0.0



970T>C


Instruction: a71369577g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 71369582 2 71369584 2.4 1.0 -1.4 -2.7 37.4 -1.7 -2.1 -0.4
No change 71369571 13 71369584 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0
No change 71369535 49 71369584 1.5 1.5 0.0 1.0 100 -2.0 -2.0 0.0



976G>T


Instruction: c71369571a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369582 2 71369584 2.4 2.4 0.0 1.0 100 -1.7 -1.7 0.0
No change 71369535 49 71369584 1.5 1.5 0.0 1.0 100 -2.0 -2.0 0.0
Decreased 71369571 13 71369584 0.4 -7.4 -7.8 -1.3 NA -2.3 -4.7 -2.4



986C>T


Instruction: g71369561a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369582 2 71369584 2.4 2.4 0.0 1.0 100 -1.7 -1.7 0.0
No change 71369571 13 71369584 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0
No change 71369535 49 71369584 1.5 1.5 0.0 1.0 100 -2.0 -2.0 0.0



1022T>C


Instruction: a71369525g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369571 13 71369584 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0
No change 71369535 49 71369584 1.5 1.5 0.0 1.0 100 -2.0 -2.0 0.0
No change 71369511 73 71369584 5.7 5.7 0.0 1.0 100 -0.7 -0.7 0.0
No change 71369490 94 71369584 2.1 2.1 0.0 1.0 100 -1.8 -1.8 0.0



1054C>T


Instruction: g71369493a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369535 49 71369584 1.5 1.5 0.0 1.0 100 -2.0 -2.0 0.0
No change 71369511 73 71369584 5.7 5.7 0.0 1.0 100 -0.7 -0.7 0.0
Decreased 71369490 94 71369584 2.1 0.5 -1.6 -3.0 32.9 -1.8 -2.3 -0.5



1055G>A


Instruction: c71369492t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369535 49 71369584 1.5 1.5 0.0 1.0 100 -2.0 -2.0 0.0
No change 71369511 73 71369584 5.7 5.7 0.0 1.0 100 -0.7 -0.7 0.0
Increased 71369490 94 71369584 2.1 4.4 2.3 4.9 489.0 -1.8 -1.1 0.7



1058T>C


Instruction: a71369489g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369535 49 71369584 1.5 1.5 0.0 1.0 100 -2.0 -2.0 0.0
No change 71369511 73 71369584 5.7 5.7 0.0 1.0 100 -0.7 -0.7 0.0
Decreased 71369490 94 71369584 2.1 -5.4 -7.5 -4.3 NA -1.8 -4.1 -2.3



1084C>T


Instruction: g71369463a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369511 73 71369584 5.7 5.7 0.0 1.0 100 -0.7 -0.7 0.0
No change 71369490 94 71369584 2.1 2.1 0.0 1.0 100 -1.8 -1.8 0.0
No change 71369418 166 71369584 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0



1138T>C


Instruction: a71369409g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369418 166 71369584 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0
No change 71369361 223 71369584 2.3 2.3 0.0 1.0 100 -1.7 -1.7 0.0



1139G>A


Instruction: c71369408t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369418 166 71369584 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0
No change 71369361 223 71369584 2.3 2.3 0.0 1.0 100 -1.7 -1.7 0.0



1139G>C


Instruction: c71369408g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369418 166 71369584 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0
No change 71369361 223 71369584 2.3 2.3 0.0 1.0 100 -1.7 -1.7 0.0



1190C>T


Instruction: g71369357a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 71369361 223 71369584 2.3 2.4 0.0 1.0 102.1 -1.7 -1.7 0.0



1210C>A


Instruction: g71369337t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369361 223 71369584 2.3 2.3 0.0 1.0 100 -1.7 -1.7 0.0



1210C>T


Instruction: g71369337a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369361 223 71369584 2.3 2.3 0.0 1.0 100 -1.7 -1.7 0.0



1219A>T


Instruction: t71369328a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369361 223 71369584 2.3 2.3 0.0 1.0 100 -1.7 -1.7 0.0



1222T>C


Instruction: a71369325g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369361 223 71369584 2.3 2.3 0.0 1.0 100 -1.7 -1.7 0.0
Increased 71369322 262 71369584 -1.3 0.3 1.6 1.2 123.5 -2.8 -2.3 0.5



1228G>C


Instruction: c71369319g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369361 223 71369584 2.3 2.3 0.0 1.0 100 -1.7 -1.7 0.0



1228G>A


Instruction: c71369319t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369361 223 71369584 2.3 2.3 0.0 1.0 100 -1.7 -1.7 0.0
Increased 71369322 262 71369584 -1.3 1.3 2.6 2.4 241.4 -2.8 -2.0 0.8



1327C>T


Instruction: g71369220a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369189 395 71369584 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0
No change 71369185 399 71369584 5.2 5.2 0.0 1.0 100 -0.9 -0.9 0.0



1328G>A


Instruction: c71369219t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369189 395 71369584 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0
No change 71369185 399 71369584 5.2 5.2 0.0 1.0 100 -0.9 -0.9 0.0



1331G>A


Instruction: c71369216t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369189 395 71369584 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0
No change 71369185 399 71369584 5.2 5.2 0.0 1.0 100 -0.9 -0.9 0.0



1337G>A


Instruction: c71369210t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369189 395 71369584 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0
No change 71369185 399 71369584 5.2 5.2 0.0 1.0 100 -0.9 -0.9 0.0



1342G>C


Instruction: c71369205g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369189 395 71369584 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0
No change 71369185 399 71369584 5.2 5.2 0.0 1.0 100 -0.9 -0.9 0.0



1342G>A


Instruction: c71369205t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369189 395 71369584 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0
No change 71369185 399 71369584 5.2 5.2 0.0 1.0 100 -0.9 -0.9 0.0



1349G>T


Instruction: c71369198a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369189 395 71369584 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0
No change 71369185 399 71369584 5.2 5.2 0.0 1.0 100 -0.9 -0.9 0.0



1384T>C


Instruction: a71369163g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369189 395 71369584 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0
No change 71369185 399 71369584 5.2 5.2 0.0 1.0 100 -0.9 -0.9 0.0



1400C>T


Instruction: g71369147a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369189 395 71369584 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0
No change 71369185 399 71369584 5.2 5.2 0.0 1.0 100 -0.9 -0.9 0.0



1406G>C


Instruction: c71369141g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369189 395 71369584 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0
No change 71369185 399 71369584 5.2 5.2 0.0 1.0 100 -0.9 -0.9 0.0
No change 71369094 490 71369584 3.0 3.0 0.0 1.0 100 -1.5 -1.5 0.0

Legend:    Site Abolished   Leaky Site   Cryptic Site created   Strengthened Pre-existing site   Pre-existing Site   Weakened Pre-existing Site