Gene: DHCR7
mRNA Accession: AF034544
Mutation:DHCR7.txt
Chromosome: chr 11

Sequence Walker  




111G>A


Instruction: c71377947t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71377960 0 71377960 8.8 8.8 0.0 1.0 100 -0.0 -0.0 0.0
No change 71377956 4 71377960 0.0 0.0 0.0 1.0 100 -1.9 -1.9 0.0
No change 71377900 60 71377960 1.2 1.2 0.0 1.0 100 -1.7 -1.7 0.0
No change 71377898 62 71377960 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0



452G>A


Instruction: c71375145t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375116 69 71375185 1.8 1.8 0.0 1.0 100 -1.5 -1.5 0.0
No change 71375097 88 71375185 1.6 1.6 0.0 1.0 100 -1.6 -1.6 0.0



762insT


Instruction: i71372691,71372692a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 71372685 -63 71372622 8.1 9.7 1.6 3.0 295.5 -0.2 0.2 0.3
Increased 71372680 -58 71372622 1.7 2.3 0.6 1.5 148.5 -1.6 -1.4 0.1
Decreased 71372677 -55 71372622 0.8 0.7 -0.1 -1.1 91.7 -1.8 -1.8 -0.0



IVS8-1G>C


Instruction: c71369584g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369592 -8 71369584 0.1 0.1 0.0 1.0 100 -1.9 -1.9 0.0
Decreased 71369584 0 71369584 13.5 6.2 -7.3 -156.4 0.6 1.0 -0.6 -1.6
Increased 71369583 1 71369584 1.4 2.1 0.7 1.7 166.6 -1.6 -1.5 0.2
No change 71369554 30 71369584 4.3 4.3 0.0 1.0 100 -1.0 -1.0 0.0
No change 71369539 45 71369584 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0
Increased 71369582 2 71369584 -4.0 2.0 6.0 3.9 388.0 -2.8 -1.5 1.3



151C>T


Instruction: g71377907a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 71377900 60 71377960 1.2 1.2 0.0 1.0 102.7 -1.7 -1.7 0.0
Increased 71377898 62 71377960 0.8 1.4 0.6 1.5 149.8 -1.8 -1.6 0.1
No change 71377869 91 71377960 1.9 1.9 0.0 1.0 100 -1.5 -1.5 0.0
No change 71377864 96 71377960 2.2 2.2 0.0 1.0 100 -1.5 -1.5 0.0



278C>T


Instruction: g71377780a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71377737 -1 71377736 9.6 9.6 0.0 1.0 100 0.2 0.2 0.0
No change 71377732 4 71377736 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
No change 71377729 7 71377736 1.1 1.1 0.0 1.0 100 -1.7 -1.7 0.0



296T>C


Instruction: a71377762g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 71377737 -1 71377736 9.6 9.6 0.0 1.0 101.5 0.2 0.2 0.0
No change 71377732 4 71377736 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
No change 71377729 7 71377736 1.1 1.1 0.0 1.0 100 -1.7 -1.7 0.0



321G>C


Instruction: c71377737g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 71377737 -1 71377736 9.6 2.3 -7.3 -156.4 0.6 0.2 -1.4 -1.6
Increased 71377732 4 71377736 1.4 4.1 2.7 6.3 628.1 -1.6 -1.0 0.6
Increased 71377729 7 71377736 1.1 2.7 1.6 3.0 303.6 -1.7 -1.4 0.4



326T>C


Instruction: a71376093g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71376098 0 71376098 6.7 6.7 0.0 1.0 100 -0.5 -0.5 0.0
No change 71376066 32 71376098 0.2 0.2 0.0 1.0 100 -1.9 -1.9 0.0
No change 71376060 38 71376098 1.7 1.7 0.0 1.0 100 -1.6 -1.6 0.0
No change 71376059 39 71376098 3.3 3.3 0.0 1.0 100 -1.2 -1.2 0.0
Decreased 71376084 14 71376098 0.0 -0.6 -0.6 -1.0 NA -1.9 -2.1 -0.1



356A>T


Instruction: t71376063a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71376084 14 71376098 0.0 0.0 0.0 1.0 100 -1.9 -1.9 0.0
No change 71376066 32 71376098 0.2 0.2 0.0 1.0 100 -1.9 -1.9 0.0
Increased 71376060 38 71376098 1.7 1.8 0.1 1.0 104.3 -1.6 -1.6 0.0
Increased 71376059 39 71376098 3.3 6.2 2.8 7.2 719.6 -1.2 -0.6 0.6
Increased 71376040 58 71376098 4.6 5.3 0.6 1.6 155.3 -0.9 -0.8 0.1



440G>A


Instruction: c71375157t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375185 0 71375185 11.8 11.8 0.0 1.0 100 0.6 0.6 0.0
No change 71375116 69 71375185 1.8 1.8 0.0 1.0 100 -1.5 -1.5 0.0



443T>G


Instruction: a71375154c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375116 69 71375185 1.8 1.8 0.0 1.0 100 -1.5 -1.5 0.0



461C>T


Instruction: g71375136a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 71375116 69 71375185 1.8 2.0 0.2 1.1 111.8 -1.5 -1.5 0.0
No change 71375097 88 71375185 1.6 1.6 0.0 1.0 100 -1.6 -1.6 0.0
No change 71375085 100 71375185 0.7 0.7 0.0 1.0 100 -1.8 -1.8 0.0



461C>G


Instruction: g71375136c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 71375116 69 71375185 1.8 0.8 -1.0 -2.0 49.2 -1.5 -1.8 -0.2
No change 71375097 88 71375185 1.6 1.6 0.0 1.0 100 -1.6 -1.6 0.0
No change 71375085 100 71375185 0.7 0.7 0.0 1.0 100 -1.8 -1.8 0.0
Increased 71375136 49 71375185 -3.1 4.2 7.3 18.0 1800.0 -2.6 -1.0 1.6



470T>C


Instruction: a71375127g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 71375116 69 71375185 1.8 1.3 -0.5 -1.5 68.3 -1.5 -1.7 -0.1
No change 71375097 88 71375185 1.6 1.6 0.0 1.0 100 -1.6 -1.6 0.0
No change 71375085 100 71375185 0.7 0.7 0.0 1.0 100 -1.8 -1.8 0.0



502T>A


Instruction: a71375095t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375116 69 71375185 1.8 1.8 0.0 1.0 100 -1.5 -1.5 0.0
Decreased 71375097 88 71375185 1.6 1.1 -0.5 -1.4 72.2 -1.6 -1.7 -0.1
Decreased 71375085 100 71375185 0.7 -2.2 -2.8 -1.6 NA -1.8 -2.4 -0.6



506C>T


Instruction: g71375091a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375116 69 71375185 1.8 1.8 0.0 1.0 100 -1.5 -1.5 0.0
No change 71375097 88 71375185 1.6 1.6 0.0 1.0 100 -1.6 -1.6 0.0
Increased 71375085 100 71375185 0.7 0.8 0.2 1.1 111.1 -1.8 -1.8 0.0
Increased 71375082 103 71375185 -0.4 0.1 0.6 1.1 110.5 -2.0 -1.9 0.1



523G>C


Instruction: c71375074g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375097 -127 71374970 1.6 1.6 0.0 1.0 100 -1.6 -1.6 0.0
No change 71375085 -115 71374970 0.7 0.7 0.0 1.0 100 -1.8 -1.8 0.0
Increased 71375072 -102 71374970 -5.1 0.8 6.0 1.8 179.3 -3.1 -1.8 1.3
Increased 71375070 -100 71374970 -1.6 0.9 2.5 1.9 187.9 -2.3 -1.7 0.6
Increased 71375067 -97 71374970 -1.0 0.9 1.9 1.9 186.8 -2.2 -1.7 0.4



529T>C


Instruction: a71375068g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375097 -127 71374970 1.6 1.6 0.0 1.0 100 -1.6 -1.6 0.0
No change 71375085 -115 71374970 0.7 0.7 0.0 1.0 100 -1.8 -1.8 0.0



533T>A


Instruction: a71375064t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375085 -115 71374970 0.7 0.7 0.0 1.0 100 -1.8 -1.8 0.0



536C>T


Instruction: g71375061a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375085 -115 71374970 0.7 0.7 0.0 1.0 100 -1.8 -1.8 0.0



546G>C


Instruction: c71375051g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71375003 -33 71374970 2.6 2.6 0.0 1.0 100 -1.4 -1.4 0.0



724C>T


Instruction: g71372730a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71372685 143 71372828 8.1 8.1 0.0 1.0 100 -0.2 -0.2 0.0
No change 71372680 148 71372828 1.7 1.7 0.0 1.0 100 -1.6 -1.6 0.0



725G>A


Instruction: c71372729t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71372685 143 71372828 8.1 8.1 0.0 1.0 100 -0.2 -0.2 0.0
No change 71372680 148 71372828 1.7 1.7 0.0 1.0 100 -1.6 -1.6 0.0
No change 71372677 151 71372828 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0



728C>G


Instruction: g71372726c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71372685 143 71372828 8.1 8.1 0.0 1.0 100 -0.2 -0.2 0.0
No change 71372680 148 71372828 1.7 1.7 0.0 1.0 100 -1.6 -1.6 0.0
No change 71372677 151 71372828 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0



730G>A


Instruction: c71372724t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71372685 -63 71372622 8.1 8.1 0.0 1.0 100 -0.2 -0.2 0.0
No change 71372680 -58 71372622 1.7 1.7 0.0 1.0 100 -1.6 -1.6 0.0
No change 71372677 -55 71372622 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0
Increased 71372723 -101 71372622 -4.9 3.2 8.2 9.5 949.8 -3.0 -1.2 1.8



740C>T


Instruction: g71372714a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71372685 -63 71372622 8.1 8.1 0.0 1.0 100 -0.2 -0.2 0.0
No change 71372680 -58 71372622 1.7 1.7 0.0 1.0 100 -1.6 -1.6 0.0
No change 71372677 -55 71372622 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0



744G>T


Instruction: c71372710a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 71372685 -63 71372622 8.1 9.0 0.9 1.9 185.5 -0.2 0.0 0.2
No change 71372680 -58 71372622 1.7 1.7 0.0 1.0 100 -1.6 -1.6 0.0
No change 71372677 -55 71372622 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0



808A>G


Instruction: t71372646c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 71372623 -1 71372622 6.6 6.2 -0.3 -1.2 80.5 -0.5 -0.6 -0.1



841G>A


Instruction: c71371678t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71371688 0 71371688 9.3 9.3 0.0 1.0 100 0.1 0.1 0.0



852C>A


Instruction: g71371667t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71371688 0 71371688 9.3 9.3 0.0 1.0 100 0.1 0.1 0.0



852C>A

Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z )Δ Z
Increased 71371657 31 71371688 -6.2 1.2 7.4 2.3 229.9 -3.3 -1.7 1.6



906C>G


Instruction: g71371613c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71371563 -8 71371555 3.3 3.3 0.0 1.0 100 -1.2 -1.2 0.0



920G>A


Instruction: c71371599t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71371563 -8 71371555 3.3 3.3 0.0 1.0 100 -1.2 -1.2 0.0
No change 71371556 -1 71371555 8.0 8.0 0.0 1.0 100 -0.2 -0.2 0.0



925G>A


Instruction: c71371594t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71371563 -8 71371555 3.3 3.3 0.0 1.0 100 -1.2 -1.2 0.0
No change 71371556 -1 71371555 8.0 8.0 0.0 1.0 100 -0.2 -0.2 0.0



931T>G


Instruction: a71371588c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 71371563 -8 71371555 3.3 2.4 -0.9 -1.9 53.8 -1.2 -1.4 -0.2
No change 71371556 -1 71371555 8.0 8.0 0.0 1.0 100 -0.2 -0.2 0.0



932G>A


Instruction: c71371587t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 71371563 -8 71371555 3.3 3.7 0.4 1.3 130.5 -1.2 -1.1 0.1
No change 71371556 -1 71371555 8.0 8.0 0.0 1.0 100 -0.2 -0.2 0.0
Increased 71371565 -10 71371555 -0.4 0.1 0.4 1.0 104.2 -2.0 -1.9 0.1



952T>A


Instruction: a71371567t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 71371563 -8 71371555 3.3 0.5 -2.8 -7.2 13.8 -1.2 -1.8 -0.6
Decreased 71371556 -1 71371555 8.0 5.4 -2.6 -6.0 16.5 -0.2 -0.8 -0.6



957G>A


Instruction: c71371562t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 71371563 -8 71371555 3.3 2.3 -1.0 -1.9 51.5 -1.2 -1.4 -0.2
Increased 71371556 -1 71371555 8.0 8.1 0.1 1.0 104.4 -0.2 -0.2 0.0



970T>C


Instruction: a71369577g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369592 -8 71369584 0.1 0.1 0.0 1.0 100 -1.9 -1.9 0.0
No change 71369584 0 71369584 13.5 13.5 0.0 1.0 100 1.0 1.0 0.0
No change 71369583 1 71369584 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
Decreased 71369554 30 71369584 4.3 4.2 -0.1 -1.1 92.4 -1.0 -1.0 -0.0
No change 71369539 45 71369584 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0



976G>T


Instruction: c71369571a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369592 -8 71369584 0.1 0.1 0.0 1.0 100 -1.9 -1.9 0.0
No change 71369584 0 71369584 13.5 13.5 0.0 1.0 100 1.0 1.0 0.0
No change 71369583 1 71369584 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
Increased 71369554 30 71369584 4.3 5.8 1.5 2.9 292.3 -1.0 -0.7 0.3
No change 71369539 45 71369584 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0



986C>T


Instruction: g71369561a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369584 0 71369584 13.5 13.5 0.0 1.0 100 1.0 1.0 0.0
No change 71369583 1 71369584 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
Increased 71369554 30 71369584 4.3 4.3 0.0 1.0 102.7 -1.0 -1.0 0.0
Decreased 71369539 45 71369584 0.8 0.8 -0.1 -1.0 96.5 -1.8 -1.8 -0.0



1022T>C


Instruction: a71369525g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369554 30 71369584 4.3 4.3 0.0 1.0 100 -1.0 -1.0 0.0
No change 71369539 45 71369584 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0
No change 71369476 108 71369584 1.6 1.6 0.0 1.0 100 -1.6 -1.6 0.0



1054C>T


Instruction: g71369493a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 71369476 108 71369584 1.6 1.9 0.2 1.2 118.1 -1.6 -1.5 0.1



1055G>A


Instruction: c71369492t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 71369476 108 71369584 1.6 1.6 -0.0 -1.0 96.9 -1.6 -1.6 -0.0
Increased 71369491 93 71369584 -2.3 5.8 8.2 57.3 5731.9 -2.4 -0.7 1.8



1058T>C


Instruction: a71369489g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 71369476 108 71369584 1.6 1.2 -0.4 -1.3 74.0 -1.6 -1.7 -0.1



1084C>T


Instruction: g71369463a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369476 108 71369584 1.6 1.6 0.0 1.0 100 -1.6 -1.6 0.0
No change 71369429 155 71369584 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0



1138T>C


Instruction: a71369409g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369429 155 71369584 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0
No change 71369383 201 71369584 0.7 0.7 0.0 1.0 100 -1.8 -1.8 0.0



1139G>A


Instruction: c71369408t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369429 155 71369584 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0
Increased 71369383 201 71369584 0.7 1.3 0.6 1.5 148.5 -1.8 -1.7 0.1



1139G>C


Instruction: c71369408g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369429 155 71369584 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0
Increased 71369383 201 71369584 0.7 1.6 0.9 1.9 188.4 -1.8 -1.6 0.2
Increased 71369399 185 71369584 -1.6 0.0 1.6 1.0 101.1 -2.3 -1.9 0.4



1190C>T


Instruction: g71369357a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369383 201 71369584 0.7 0.7 0.0 1.0 100 -1.8 -1.8 0.0



1190C>T

Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z )Δ Z
Increased 71369318 266 71369584 -7.6 0.6 8.2 1.5 147.5 -3.6 -1.8 1.8



1327C>T


Instruction: g71369220a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369240 344 71369584 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0
Increased 71369209 375 71369584 0.1 0.6 0.5 1.5 146.3 -1.9 -1.8 0.1



1328G>A


Instruction: c71369219t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369240 344 71369584 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0
Decreased 71369209 375 71369584 0.1 -0.4 -0.4 -1.1 NA -1.9 -2.0 -0.1



1331G>A


Instruction: c71369216t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369240 344 71369584 0.8 0.8 0.0 1.0 100 -1.8 -1.8 0.0
No change 71369209 375 71369584 0.1 0.1 0.0 1.0 100 -1.9 -1.9 0.0



1337G>A


Instruction: c71369210t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 71369209 375 71369584 0.1 8.2 8.2 286.2 28616.6 -1.9 -0.1 1.8



1342G>C


Instruction: c71369205g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369209 375 71369584 0.1 0.1 0.0 1.0 100 -1.9 -1.9 0.0
Increased 71369203 381 71369584 -4.7 1.2 6.0 2.3 234.6 -3.0 -1.7 1.3



1342G>A


Instruction: c71369205t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369209 375 71369584 0.1 0.1 0.0 1.0 100 -1.9 -1.9 0.0



1349G>T


Instruction: c71369198a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369209 375 71369584 0.1 0.1 0.0 1.0 100 -1.9 -1.9 0.0



1384T>C


Instruction: a71369163g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369118 466 71369584 2.2 2.2 0.0 1.0 100 -1.5 -1.5 0.0



1400C>T


Instruction: g71369147a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 71369118 466 71369584 2.2 2.2 0.0 1.0 100 -1.5 -1.5 0.0



1406G>C


Instruction: c71369141g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 71369118 466 71369584 2.2 3.1 0.8 1.8 178.1 -1.5 -1.3 0.2

Legend:    Site Abolished   Leaky Site   Cryptic Site created   Strengthened Pre-existing site   Pre-existing Site   Weakened Pre-existing Site