Allele Protein__ Nucleotide changes


cDNA_____ gene


M18907___ AF280107 Trivial name Effect Enzyme activity References________ In_vivo In_vitro


CYP3A4*1A CYP3A4.1 None None Wild-type Normal Normal Gonzalez et al, 1988


CYP3A4*1B CYP3A4.1 CYP3A4-V ? ? Rebbeck et al, 1998 Westlind et al, 1999


CYP3A4*1C CYP3A4.1 g.-444TG Kuehl el al, 2001


CYP3A4*1D CYP3A4.1 g.-62CA Kuehl el al, 2001


CYP3A4*1E CYP3A4.1 g.-369TA Hamzeiy et al, 2002


CYP3A4*1F CYP3A4.1 g.-747CG Hamzeiy et al, 2002


CYP3A4*2 CYP3A4.2 S222P Sata et al, 2000


CYP3A4*3 CYP3A4.3 c.1334T>C M445T Sata et al, 2000


CYP3A4*4 CYP3A4.4 c.352A>G I118V Hsieh et al, 2001


CYP3A4*5 CYP3A4.5 c.653C>G P218R Hsieh et al, 2001


CYP3A4*6 c.831insA frameshift Hsieh et al, 2001


CYP3A4*7 CYP3A4.7 c.167G>A g.6004GA G56D Eiselt et al, 2001


CYP3A4*8 CYP3A4.8 c.389G>A g.13908GA R130Q Eiselt et al, 2001


CYP3A4*9 CYP3A4.9 c.508G>A g.14292GA V170I Eiselt et al, 2001


CYP3A4*10 CYP3A4.10 c.520G>C g.14304GC D174H Eiselt et al, 2001


CYP3A4*11 CYP3A4.11 c.1088C>T g.21867CT T363M Eiselt et al, 2001


CYP3A4*12 CYP3A4.12 c.1117C>T g.21896CT L373F Eiselt et al, 2001


CYP3A4*13 CYP3A4.13 c.1247C>T g.22026CT P416L Eiselt et al, 2001


CYP3A4*14 CYP3A4.14 c.44T>C g.44TC L15P Lamba et al, 2002


CYP3A4*15A CYP3A4.15 c.485G>A g.14269GA R162Q Lamba et al, 2002


CYP3A4*16 CYP3A4.16 c.554C>G g.15603CG T185S Lamba et al, 2002


CYP3A4*17 CYP3A4.17 c.566T>C g.15615TC F189S Decr Dai et al, 2001


CYP3A4*18 CYP3A4.18 c.878T>C g.20070TC L293P Incr Dai et al, 2001


CYP3A4*19 CYP3A4.19 c.1399C>T IVS10+12G>A g.23237CT; g.20230GA P467S Dai et al, 2001





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