Gene: CYP3A4
mRNA Accession: M18907
Mutation:CYP3A4.txt
Chromosome: chr 7

Sequence Walker  




1088C>T


Instruction: g98957424a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 98957437 49 98957486 2.3 2.3 0.0 1.0 100 -1.7 -1.7 0.0
No change 98957434 52 98957486 5.9 5.9 0.0 1.0 100 -0.6 -0.6 0.0
No change 98957386 100 98957486 1.0 1.0 0.0 1.0 100 -2.1 -2.1 0.0



1117C>T


Instruction: g98957395a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 98957437 49 98957486 2.3 2.3 0.0 1.0 100 -1.7 -1.7 0.0
No change 98957434 52 98957486 5.9 5.9 0.0 1.0 100 -0.6 -0.6 0.0
No change 98957386 100 98957486 1.0 1.0 0.0 1.0 100 -2.1 -2.1 0.0
No change 98957370 116 98957486 0.1 0.1 0.0 1.0 100 -2.4 -2.4 0.0



1247C>T


Instruction: g98957265a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 98957304 -46 98957258 0.5 0.5 0.0 1.0 100 -2.3 -2.3 0.0
No change 98957294 -36 98957258 1.7 1.7 0.0 1.0 100 -1.9 -1.9 0.0
No change 98957258 0 98957258 4.8 4.8 0.0 1.0 100 -1.0 -1.0 0.0
No change 98957244 14 98957258 1.6 1.6 0.0 1.0 100 -2.0 -2.0 0.0



1334T>C


Instruction: a98956119g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 98956143 57 98956200 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0
No change 98956115 85 98956200 2.0 2.0 0.0 1.0 100 -1.8 -1.8 0.0



167G>A


Instruction: c98973297t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 98973348 -49 98973299 1.5 1.5 0.0 1.0 100 -2.0 -2.0 0.0
No change 98973344 -45 98973299 1.0 1.0 0.0 1.0 100 -2.1 -2.1 0.0
No change 98973291 8 98973299 2.1 2.1 0.0 1.0 100 -1.8 -1.8 0.0
No change 98973263 36 98973299 5.2 5.2 0.0 1.0 100 -0.9 -0.9 0.0
No change 98973253 46 98973299 5.2 5.2 0.0 1.0 100 -0.9 -0.9 0.0
No change 98973251 48 98973299 3.2 3.2 0.0 1.0 100 -1.5 -1.5 0.0



352A>G


Instruction: t98965420c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 98965441 13 98965454 2.6 2.6 0.0 1.0 100 -1.7 -1.7 0.0
Increased 98965425 29 98965454 -0.0 0.4 0.4 1.3 127.5 -2.4 -2.3 0.1



389G>A


Instruction: c98965383t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 98965339 0 98965339 6.9 6.9 0.0 1.0 100 -0.3 -0.3 0.0



44T>C


Instruction: a98979256g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 98979305 -77 98979228 1.8 1.8 0.0 1.0 100 -1.9 -1.9 0.0
No change 98979302 -74 98979228 1.3 1.3 0.0 1.0 100 -2.1 -2.1 0.0
No change 98979242 -14 98979228 1.6 1.6 0.0 1.0 100 -1.9 -1.9 0.0
No change 98979228 0 98979228 5.4 5.4 0.0 1.0 100 -0.8 -0.8 0.0
No change 98979224 4 98979228 2.2 2.2 0.0 1.0 100 -1.8 -1.8 0.0



485G>A


Instruction: c98965022t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 98965054 -69 98964985 3.3 3.3 0.0 1.0 100 -1.4 -1.4 0.0
No change 98965044 -59 98964985 0.0 0.0 0.0 1.0 100 -2.4 -2.4 0.0
No change 98965038 -53 98964985 7.0 7.0 0.0 1.0 100 -0.3 -0.3 0.0
No change 98965007 -22 98964985 3.6 3.6 0.0 1.0 100 -1.3 -1.3 0.0
No change 98964985 0 98964985 7.2 7.2 0.0 1.0 100 -0.2 -0.2 0.0
No change 98964981 4 98964985 0.8 0.8 0.0 1.0 100 -2.2 -2.2 0.0



508G>A


Instruction: c98964999t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 98965044 -59 98964985 0.0 0.0 0.0 1.0 100 -2.4 -2.4 0.0
No change 98965038 -53 98964985 7.0 7.0 0.0 1.0 100 -0.3 -0.3 0.0
No change 98965007 -22 98964985 3.6 3.6 0.0 1.0 100 -1.3 -1.3 0.0
No change 98964985 0 98964985 7.2 7.2 0.0 1.0 100 -0.2 -0.2 0.0
No change 98964981 4 98964985 0.8 0.8 0.0 1.0 100 -2.2 -2.2 0.0



520G>C


Instruction: c98964987g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 98965038 -53 98964985 7.0 7.0 0.0 1.0 100 -0.3 -0.3 0.0
No change 98965007 -22 98964985 3.6 3.6 0.0 1.0 100 -1.3 -1.3 0.0
Increased 98964985 0 98964985 7.2 7.5 0.3 1.2 120.0 -0.2 -0.2 0.1
No change 98964981 4 98964985 0.8 0.8 0.0 1.0 100 -2.2 -2.2 0.0



653C>G


Instruction: g98963589c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 98963571 0 98963571 5.4 5.4 0.0 1.0 100 -0.8 -0.8 0.0



831insA


Instruction: i98961628,98961629t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 98961655 7 98961662 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0
No change 98961594 68 98961662 7.2 7.2 0.0 1.0 100 -0.2 -0.2 0.0

Legend:    Site Abolished   Leaky Site   Cryptic Site created   Strengthened Pre-existing site   Pre-existing Site   Weakened Pre-existing Site