Gene: CYP3A4
mRNA Accession: M18907
Mutation:CYP3A4.txt
Chromosome: chr 7

Sequence Walker  




1247C>T


Instruction: g98957265a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 98957294 -36 98957258 0.4 0.4 0.0 1.0 100 -1.8 -1.8 0.0
Increased 98957259 -1 98957258 1.3 1.5 0.2 1.1 111.1 -1.6 -1.6 0.0



1334T>C


Instruction: a98956119g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 98956080 120 98956200 1.1 1.1 0.0 1.0 100 -1.7 -1.7 0.0
No change 98956070 130 98956200 3.4 3.4 0.0 1.0 100 -1.2 -1.2 0.0



167G>A


Instruction: c98973297t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 98973299 0 98973299 14.9 14.9 0.0 1.0 103.1 1.3 1.3 0.0
Decreased 98973298 1 98973299 2.5 1.5 -1.0 -1.9 51.5 -1.4 -1.6 -0.2



352A>G


Instruction: t98965420c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 98965441 13 98965454 6.0 6.0 0.0 1.0 100 -0.6 -0.6 0.0
Increased 98965411 43 98965454 2.5 3.0 0.4 1.3 133.5 -1.4 -1.3 0.1



389G>A


Instruction: c98965383t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 98965411 -72 98965339 2.5 2.5 0.0 1.0 100 -1.4 -1.4 0.0
No change 98965356 -17 98965339 4.8 4.8 0.0 1.0 100 -0.9 -0.9 0.0



44T>C


Instruction: a98979256g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 98979284 -56 98979228 3.7 3.7 0.0 1.0 100 -1.1 -1.1 0.0
Decreased 98979247 -19 98979228 4.3 3.7 -0.6 -1.5 66.7 -1.0 -1.1 -0.1
No change 98979224 4 98979228 0.6 0.6 0.0 1.0 100 -1.8 -1.8 0.0
No change 98979213 15 98979228 3.8 3.8 0.0 1.0 100 -1.1 -1.1 0.0



520G>C


Instruction: c98964987g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 98964936 49 98964985 3.9 3.9 0.0 1.0 100 -1.1 -1.1 0.0



653C>G


Instruction: g98963589c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 98963575 -4 98963571 3.2 1.9 -1.3 -2.5 40.5 -1.2 -1.5 -0.3
Decreased 98963572 -1 98963571 3.2 1.9 -1.3 -2.5 40.3 -1.2 -1.5 -0.3
Decreased 98963571 0 98963571 3.2 2.4 -0.8 -1.8 55.6 -1.2 -1.4 -0.2
No change 98963538 33 98963571 3.0 3.0 0.0 1.0 100 -1.3 -1.3 0.0
Decreased 98963574 -3 98963571 0.6 -0.5 -1.1 -1.5 NA -1.8 -2.0 -0.2



831insA


Instruction: i98961628,98961629t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 98961657 5 98961662 2.8 2.8 0.0 1.0 100 -1.3 -1.3 0.0
No change 98961655 7 98961662 2.2 2.2 0.0 1.0 100 -1.5 -1.5 0.0
No change 98961641 21 98961662 4.5 4.5 0.0 1.0 100 -1.0 -1.0 0.0
Decreased 98961623 39 98961662 5.1 3.5 -1.6 -3.0 33.4 -0.8 -1.2 -0.3

Legend:    Site Abolished   Leaky Site   Cryptic Site created   Strengthened Pre-existing site   Pre-existing Site   Weakened Pre-existing Site