Note: The original file submitted is modified to provide links to the results.


CYP2B6 allele nomenclature




Allele
Protein
Nucleotide changes
Effect
Enzyme activity
References
cDNA, NM_000767 
In_vivo
In_vitro
CYP2B6*1A
CYP2B6.1
 
Hesse et al, 2004
CYP2B6*2A
CYP2B6.2
64C>T
R22C
 
 
Lang et al, 2001
CYP2B6*2B
CYP2B6.2
64C>T + 216G>C
R22C




Lamba et al, 2003
CYP2B6*3
CYP2B6.3
777C>A
S259R
 
 
Lang et al, 2001
CYP2B6*4A
CYP2B6.4
785A>G
K262R
 
 
Lang et al, 2001
CYP2B6*4B
CYP2B6.4
785A>G
K262R
 
 
Hesse et al, 2004
CYP2B6*4C
CYP2B6.4
785A>G
K262R
 
 
Jacob et al., 2004
CYP2B6*5A
CYP2B6.5
1459C>T
R487C
 
 
Lang et al, 2001
CYP2B6*5B
CYP2B6.5
1459C>T
R487C
 
 
Hesse et al, 2004
CYP2B6*6A
CYP2B6.6
516G>T + 785A>G
Q172H; K262R
 
 
Lang et al, 2001
CYP2B6*6B
CYP2B6.6
516G>T + 785A>G
Q172H; K262R
 
 
Hesse et al, 2004
CYP2B6*7A
CYP2B6.7
516G>T + 785A>G + 1459C>T
Q172H; K262R; R487C
 
 
Lang et al, 2001
CYP2B6*7B
CYP2B6.7
516G>T + 785A>G + 1459C>T
Q172H; K262R; R487C




Hesse et al, 2004
CYP2B6*8
CYP2B6.8
415A>G
K139E


Decr. expr.

Lamba et al, 2003 Lang et al., in press, JPET
CYP2B6*9
CYP2B6.9
516G>T
Q172H




Lamba et al, 2003
CYP2B6*10
CYP2B6.10
62A>T + 64C>T + 216G>C
Q21L; R22C
 
 
Lang et al., in press, JPET
CYP2B6*11A
CYP2B6.11
136A>G
M46V
 
Decr. expr.
Lang et al., in press, JPET
CYP2B6*11B
CYP2B6.11
136A>G
M46V
 
Decr. expr.
Lang et al., in press, JPET
CYP2B6*12 Tentative allele
CYP2B6.12
296G>A
G99E
 
Decr. expr.
Lang et al., in press, JPET
CYP2B6*13A
CYP2B6.13
415A>G + 516G>T + 785A>G
K139E; Q172H; K262R
 
Decreased?
Lang et al., in press, JPET
CYP2B6*13B
CYP2B6.13
415A>G + 516G>T + 785A>G
K139E; Q172H; K262R
 
Decreased?
Lang et al., in press, JPET
CYP2B6*14 Tentative allele
CYP2B6.14
419G>A
R140Q
 
Decr. act.
Lang et al., in press, JPET
CYP2B6*15A
CYP2B6.15
1172T>A
I391N
 
Decr. expr.
Lang et al., in press, JPET
CYP2B6*15B
CYP2B6.15
1172T>A
I391N
 
Decr. expr.
Lang et al., in press, JPET
SwissProt OMIM GeneCards