Table 2. Polymorphisms in the COX1 Gene (Coding Region and Adjacent Sequence)


Variant allele frequency


Exon/


Intron1 Nucleotide change2 Codon Amino acid change African-American Caucasian Minnesota


Caucasian



n=48 n=47 n=94




Exon/


Intron1 Nucleotide change2 Codon Amino acid change


Exon 2 22C>T CGG>TGG R8W


50C>T CCG>CTG P17L



Exon 3 123G>A CAG>CAA Q41Q


158G>A CGC>CAG R53H


204C>T TGC>TGT C68C








Intron 3 CTTCCG/ATCTTG IVS3+32G>A


-- --


Exon 6 554A>C AAG>ACG K185T


639C>A GGC>GGA G213G






Intron 6 CACGCG/ATATGT IVS6+51G>A


-- --


Exon 7 688G>A GGC>AGC G230S


709C>A CTG>ATG L237M





Intron 7 GGGCC(delA)GGGGG IVS7+14delA


-- --


Intron 7 AGCTGT/CGGGTG IVS7-45T>C


-- --


Exon 9 1022A>G AAG>AGG K341R


Exon 10 1428C>T TCC>TCT S476S


Intron 10 TCTGAT/CGCTAG IVS10-29T>C


-- --


Exon 11 1497G>A GCG>GCA A499A


1512T>C CCT>CCC P504P





http://download.interscience.wiley.com/cgi-bin/fulltext?ID=99018987&PLACEBO=IE.pdf&mode=pdf



http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Search&db=Nucleotide&term=M59979&doptcmdl=GenBank&tool=genome.ucsc.edu




MUTATION IN BRIEF


HUMAN MUTATION Mutation in Brief #551 (2002) O nline


Cyclooxygenase 1 (COX1) Polymorphisms in African-


American and Caucasian Populations


Cornelia M Ulrich1,3 *, Jeannette Bigler1, Justin Sibert1, Elizabeth A Greene 2, Rachel Sparks1,3,


Christopher S Carlson4, and John D Potter1,3


1Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, and 2Bioinformatics Center; 3University of Washington, Department of Epidemiology, and 4Department of Genome Sciences










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