Gene: COL1A1
mRNA Accession: Z74615
Chromosome: chr 17

Sequence Walker  




IVS3+1G>C


Instruction: c48618995g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 48618966 2948618995 0.0 0.0 0.0 1.0100 -1.9 -1.9 0.0
No Change 48618944 5148618995 4.3 4.3 0.0 1.0100 -1.0 -1.0 0.0
Sites found for donor
No Change 48618957 3848618995 2.1 2.1 0.0 1.0100 -1.8 -1.8 0.0
Decreased48618995048618995 5.7 -4.1 -9.8 -52.2NA -0.7 -3.7 -3.0



c.333G>T;.c333+1G>C


Instruction: c48619277a.c48619192g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Decreased48619193 -1 48619192 4.9 3.0 -1.9 -3.826.5 -0.9 -1.3 -0.4
Sites found for donor
No Change 48619294 -10248619192 1.3 1.3 0.0 1.0100 -2.0 -2.0 0.0
No Change 48619289 -9748619192 3.4 3.4 0.0 1.0100 -1.4 -1.4 0.0
No Change 48619284 -9248619192 0.5 0.5 0.0 1.0100 -2.3 -2.3 0.0
Decreased48619274 -82 48619192 1.3 0.8 -0.4 -1.473.7 -2.1 -2.2 -0.1
No Change 48619267 -7548619192 0.2 0.2 0.0 1.0100 -2.4 -2.4 0.0
No Change 48619225 -3348619192 2.8 2.8 0.0 1.0100 -1.6 -1.6 0.0
Decreased48619192048619192 7.8 -2.0 -9.8 -227.8NA -0.1 -3.0 -3.0



IVS5-2A>G


Instruction: t48617946c ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 48617965 -2048617945 0.6 0.6 0.0 1.0100 -1.8 -1.8 0.0
No Change 48617955 -1048617945 0.2 0.2 0.0 1.0100 -1.9 -1.9 0.0
Decreased48617945 0 48617945 10.9 2.7 -8.2 -286.20.3 0.4 -1.3 -1.8
Increased 48617930 1548617945 7.4 7.4 0.0 1.0103.1 -0.3 -0.3 0.0
increased48617946-148617945 -3.1 4.5 7.6 22.22215.5 -2.6 -1.0 1.7
Sites found for donor



IVS5-1G>A


Instruction: c48617945t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 48617965 -2048617945 0.6 0.6 0.0 1.0100 -1.8 -1.8 0.0
No Change 48617955 -1048617945 0.2 0.2 0.0 1.0100 -1.9 -1.9 0.0
Decreased48617945 0 48617945 10.9 3.3 -7.6 -191.10.5 0.4 -1.2 -1.7
Decreased48617930 15 48617945 7.4 7.1 -0.2 -1.285.8 -0.3 -0.4 -0.0
increased48617943248617945 -0.2 1.5 1.7 2.9292.8 -2.0 -1.6 0.4
Sites found for donor



c.503G>A


Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Unprocessed due to the following error. c.503G>A the old base at 48618753 is NOT c! It is g.



IVS8+1G>C


Instruction: c48617388g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Increased 48617370 1848617388 5.6 6.4 0.8 1.8179.6 -0.7 -0.5 0.2
No Change 48617351 3748617388 1.3 1.3 0.0 1.0100 -1.6 -1.6 0.0
No Change 48617343 4548617388 3.1 3.1 0.0 1.0100 -1.3 -1.3 0.0
Sites found for donor
No Change 48617414 -2648617388 8.6 8.6 0.0 1.0100 0.2 0.2 0.0
No Change 48617405 -1748617388 1.1 1.1 0.0 1.0100 -2.1 -2.1 0.0
Decreased48617388048617388 4.6 -5.2 -9.8 -24.9NA -1.0 -4.0 -3.0



IVS9-1G>T


Instruction: c48616674a ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Decreased48616674 0 48616674 14.2 5.5 -8.7 -430.00.2 1.2 -0.7 -1.9
Increased 48616673 148616674 2.7 3.4 0.7 1.7166.6 -1.4 -1.2 0.2
Increased 48616667 748616674 0.2 2.1 2.0 3.9391.8 -1.9 -1.5 0.4
increased48616672248616674 -0.3 4.0 4.3 16.21620.7 -2.0 -1.1 0.9
Sites found for donor
No Change 48616718 -4448616674 1.8 1.8 0.0 1.0100 -1.9 -1.9 0.0
No Change 48616715 -4148616674 5.3 5.3 0.0 1.0100 -0.8 -0.8 0.0
No Change 48616645 2948616674 9.2 9.2 0.0 1.0100 0.4 0.4 0.0
No Change 48616639 3548616674 1.6 1.6 0.0 1.0100 -1.9 -1.9 0.0



IVS11+3-+6delGAGT


Instruction: d48616444,48616447 ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Increased 48616425 2448616449 0.1 0.5 0.3 1.3125.1 -1.9 -1.8 0.1
No Change 48616416 3348616449 0.7 0.7 0.0 1.0100 -1.8 -1.8 0.0
No Change 48616409 4048616449 2.2 2.2 0.0 1.0100 -1.5 -1.5 0.0
Sites found for donor
Decreased48616449048616449 6.6 -10.7 -17.3 -98.2NA -0.4 -5.7 -5.3



IVS12+1G>A


Instruction: c48616056t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Decreased48616057 -1 48616056 1.3 0.4 -1.0 -1.951.5 -1.6 -1.9 -0.2
No Change 48616016 4048616056 6.9 6.9 0.0 1.0100 -0.4 -0.4 0.0
No Change 48616014 4248616056 1.1 1.1 0.0 1.0100 -1.7 -1.7 0.0
Sites found for donor
No Change 48616100 -4448616056 0.6 0.6 0.0 1.0100 -2.2 -2.2 0.0
No Change 48616091 -3548616056 1.4 1.4 0.0 1.0100 -2.0 -2.0 0.0
Decreased48616056048616056 11.4 -1.4 -12.8 -2677.4NA 1.0 -2.9 -3.9



IVS13-10T>A


Instruction: a48615817t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 48615821 -1348615808 3.1 3.1 0.0 1.0100 -1.3 -1.3 0.0
Decreased48615808 0 48615808 8.4 5.8 -2.6 -6.116.3 -0.1 -0.7 -0.6
increased48615816-848615808 -0.3 7.1 7.4 140.114005.3 -2.0 -0.4 1.6
Sites found for donor
No Change 48615812 -448615808 0.5 0.5 0.0 1.0100 -2.3 -2.3 0.0
No Change 48615788 2048615808 9.0 9.0 0.0 1.0100 0.3 0.3 0.0
increased48615820-1248615808 -0.3 2.8 3.1 6.8676.1 -2.5 -1.6 0.9



c.904-10T>A


Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Unprocessed due to the following error. c.904-10T>A the old base at 48616513 is NOT a! It is g.



IVS14+5G>A


Instruction: c48615749t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 48615700 5348615753 0.7 0.7 0.0 1.0100 -1.8 -1.8 0.0
Sites found for donor
No Change 48615788 -3548615753 9.0 9.0 0.0 1.0100 0.3 0.3 0.0
Decreased48615753 0 48615753 6.2 2.7 -3.5 -11.58.7 -0.5 -1.6 -1.1



IVS15-33--44delCTGCCATCTCTT


Instruction: d48615661,48615672 ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 48615700 -6048615640 0.7 0.7 0.0 1.0100 -1.8 -1.8 0.0
Decreased48615643 -3 48615640 3.1 2.4 -0.7 -1.759.7 -1.3 -1.4 -0.2
Increased 48615640 048615640 12.8 14.0 1.2 2.4236.5 0.9 1.1 0.3
Sites found for donor
No Change 48615638 248615640 1.9 1.9 0.0 1.0100 -1.9 -1.9 0.0



IVS16-2A>G


Instruction: t48615107c ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 48615112 -648615106 2.4 2.4 0.0 1.0100 -1.4 -1.4 0.0
Decreased48615106 0 48615106 11.4 3.3 -8.2 -286.20.3 0.6 -1.2 -1.8
No Change 48615069 3748615106 0.6 0.6 0.0 1.0100 -1.8 -1.8 0.0
No Change 48615061 4548615106 0.8 0.8 0.0 1.0100 -1.8 -1.8 0.0
increased48615107-148615106 -6.6 0.9 7.6 1.9192.8 -3.4 -1.7 1.7
increased48615099748615106 -0.1 0.2 0.3 1.2116.4 -2.0 -1.9 0.1
Sites found for donor
No Change 48615158 -5248615106 2.3 2.3 0.0 1.0100 -1.7 -1.7 0.0
No Change 48615153 -4748615106 3.8 3.8 0.0 1.0100 -1.3 -1.3 0.0
No Change 48615138 -3248615106 2.8 2.8 0.0 1.0100 -1.6 -1.6 0.0
Decreased48615104 2 48615106 4.9 3.9 -1.0 -2.049.9 -0.9 -1.2 -0.3
No Change 48615059 4748615106 5.8 5.8 0.0 1.0100 -0.7 -0.7 0.0



IVS17+1G>C


Instruction: c48615006g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 48615024 -1848615006 2.2 2.2 0.0 1.0100 -1.5 -1.5 0.0
No Change 48615015 -948615006 0.6 0.6 0.0 1.0100 -1.8 -1.8 0.0
Increased 48614988 1848615006 2.6 3.5 0.8 1.8179.6 -1.4 -1.2 0.2
No Change 48614966 4048615006 0.4 0.4 0.0 1.0100 -1.9 -1.9 0.0
No Change 48614960 4648615006 9.9 9.9 0.0 1.0100 0.2 0.2 0.0
No Change 48614958 4848615006 2.8 2.8 0.0 1.0100 -1.3 -1.3 0.0
increased48615002448615006 -2.0 0.5 2.5 1.4140.9 -2.4 -1.8 0.6
Sites found for donor
No Change 48615057 -5148615006 2.9 2.9 0.0 1.0100 -1.6 -1.6 0.0
No Change 48615050 -4448615006 7.4 7.4 0.0 1.0100 -0.2 -0.2 0.0
No Change 48615023 -1748615006 1.8 1.8 0.0 1.0100 -1.9 -1.9 0.0
Decreased48615006048615006 6.6 -3.2 -9.8 -99.1NA -0.4 -3.4 -3.0



IVS18+1G>A


Instruction: c48614873t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Increased 48614851 2248614873 1.3 1.8 0.4 1.4135.5 -1.6 -1.5 0.1
No Change 48614830 4348614873 8.1 8.1 0.0 1.0100 -0.2 -0.2 0.0
Decreased486148581548614873 0.1 -0.2 -0.2 -1.0NA -1.9 -2.0 -0.0
Sites found for donor
No Change 48614908 -3548614873 2.0 2.0 0.0 1.0100 -1.8 -1.8 0.0
No Change 48614890 -1748614873 1.6 1.6 0.0 1.0100 -1.9 -1.9 0.0
No Change 48614881 -848614873 3.6 3.6 0.0 1.0100 -1.3 -1.3 0.0
Decreased48614873048614873 9.3 -3.5 -12.8 -613.6NA 0.4 -3.5 -3.9



IVS18-1G>A


Instruction: c48614771t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 48614800 -2948614771 0.9 0.9 0.0 1.0100 -1.7 -1.7 0.0
No Change 48614795 -2448614771 1.2 1.2 0.0 1.0100 -1.7 -1.7 0.0
Increased 48614773 -248614771 2.2 2.2 0.0 1.0103.1 -1.5 -1.5 0.0
Decreased48614771 0 48614771 10.4 2.8 -7.6 -191.10.5 0.3 -1.3 -1.7
Increased 48614752 1948614771 0.0 0.2 0.2 1.1113.7 -1.9 -1.9 0.0
No Change 48614734 3748614771 2.5 2.5 0.0 1.0100 -1.4 -1.4 0.0
No Change 48614725 4648614771 2.3 2.3 0.0 1.0100 -1.4 -1.4 0.0
increased48614770148614771 -2.6 5.6 8.2 47.74770.3 -2.5 -0.7 1.8
Sites found for donor
Increased 48614769 248614771 1.3 3.6 2.3 4.9489.0 -2.0 -1.4 0.7
No Change 48614760 1148614771 2.2 2.2 0.0 1.0100 -1.8 -1.8 0.0
No Change 48614751 2048614771 1.6 1.6 0.0 1.0100 -1.9 -1.9 0.0
No Change 48614733 3848614771 2.2 2.2 0.0 1.0100 -1.8 -1.8 0.0



IVS19+1G>A


Instruction: c48614671t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 48614681 -1048614671 3.6 3.6 0.0 1.0100 -1.1 -1.1 0.0
No Change 48614643 2848614671 0.4 0.4 0.0 1.0100 -1.8 -1.8 0.0
No Change 48614638 3348614671 2.6 2.6 0.0 1.0100 -1.4 -1.4 0.0
No Change 48614634 3748614671 0.9 0.9 0.0 1.0100 -1.8 -1.8 0.0
No Change 48614632 3948614671 0.2 0.2 0.0 1.0100 -1.9 -1.9 0.0
No Change 48614625 4648614671 3.9 3.9 0.0 1.0100 -1.1 -1.1 0.0
Sites found for donor
No Change 48614679 -848614671 5.1 5.1 0.0 1.0100 -0.9 -0.9 0.0
No Change 48614625 4648614671 2.8 2.8 0.0 1.0100 -1.6 -1.6 0.0
Decreased48614671048614671 5.8 -7.0 -12.8 -57.3NA -0.7 -4.6 -3.9



IVS19+1G>C


Instruction: c48614671g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 48614681 -1048614671 3.6 3.6 0.0 1.0100 -1.1 -1.1 0.0
No Change 48614643 2848614671 0.4 0.4 0.0 1.0100 -1.8 -1.8 0.0
No Change 48614638 3348614671 2.6 2.6 0.0 1.0100 -1.4 -1.4 0.0
No Change 48614634 3748614671 0.9 0.9 0.0 1.0100 -1.8 -1.8 0.0
No Change 48614632 3948614671 0.2 0.2 0.0 1.0100 -1.9 -1.9 0.0
No Change 48614625 4648614671 3.9 3.9 0.0 1.0100 -1.1 -1.1 0.0
Sites found for donor
No Change 48614679 -848614671 5.1 5.1 0.0 1.0100 -0.9 -0.9 0.0
No Change 48614625 4648614671 2.8 2.8 0.0 1.0100 -1.6 -1.6 0.0
Decreased48614671048614671 5.8 -4.0 -9.8 -57.3NA -0.7 -3.6 -3.0



c.1299+1G>C


Instruction: c48614873g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Increased 48614858 1548614873 0.1 1.2 1.1 2.2216.5 -1.9 -1.7 0.2
Increased 48614851 2248614873 1.3 2.3 0.9 1.9192.0 -1.6 -1.4 0.2
No Change 48614830 4348614873 8.1 8.1 0.0 1.0100 -0.2 -0.2 0.0
Sites found for donor
No Change 48614908 -3548614873 2.0 2.0 0.0 1.0100 -1.8 -1.8 0.0
No Change 48614890 -1748614873 1.6 1.6 0.0 1.0100 -1.9 -1.9 0.0
No Change 48614881 -848614873 3.6 3.6 0.0 1.0100 -1.3 -1.3 0.0
Decreased48614873048614873 9.3 -0.5 -9.8 -613.6NA 0.4 -2.6 -3.0



IVS20-2A>G


Instruction: t48614270c ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 48614297 -2848614269 4.5 4.5 0.0 1.0100 -1.0 -1.0 0.0
No Change 48614280 -1148614269 1.2 1.2 0.0 1.0100 -1.7 -1.7 0.0
No Change 48614279 -1048614269 0.8 0.8 0.0 1.0100 -1.8 -1.8 0.0
Decreased48614269 0 48614269 12.7 4.5 -8.2 -286.20.3 0.8 -0.9 -1.8
Decreased48614250 19 48614269 3.5 3.2 -0.3 -1.281.8 -1.2 -1.2 -0.1
No Change 48614232 3748614269 0.4 0.4 0.0 1.0100 -1.9 -1.9 0.0
No Change 48614229 4048614269 0.5 0.5 0.0 1.0100 -1.8 -1.8 0.0
increased48614270-148614269 -2.5 5.1 7.6 33.33333.6 -2.5 -0.8 1.7
Sites found for donor
No Change 48614262 748614269 0.7 0.7 0.0 1.0100 -2.2 -2.2 0.0
No Change 48614258 1148614269 0.2 0.2 0.0 1.0100 -2.4 -2.4 0.0
No Change 48614231 3848614269 1.2 1.2 0.0 1.0100 -2.1 -2.1 0.0
No Change 48614222 4748614269 3.8 3.8 0.0 1.0100 -1.3 -1.3 0.0



IVS20+2T>C


Instruction: a48614485g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 48614459 2748614486 9.9 9.9 0.0 1.0100 0.2 0.2 0.0
No Change 48614454 3248614486 7.0 7.0 0.0 1.0100 -0.4 -0.4 0.0
No Change 48614439 4748614486 5.1 5.1 0.0 1.0100 -0.8 -0.8 0.0
Sites found for donor
No Change 48614530 -4448614486 1.6 1.6 0.0 1.0100 -1.9 -1.9 0.0
No Change 48614503 -1748614486 1.6 1.6 0.0 1.0100 -1.9 -1.9 0.0
No Change 48614494 -848614486 0.5 0.5 0.0 1.0100 -2.3 -2.3 0.0
Decreased48614486048614486 7.2 -0.3 -7.5 -145.0NA -0.3 -2.5 -2.3



IVS19-12G>A


Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Unprocessed due to the following error. IVS19-12G>A the old base at 48614552 is NOT c! It is g.



IVS22-1G>T


Instruction: c48613888a ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 48613892 -448613888 0.1 0.1 0.0 1.0100 -1.9 -1.9 0.0
No Change 48613851 3748613888 1.5 1.5 0.0 1.0100 -1.6 -1.6 0.0
No Change 48613842 4648613888 5.3 5.3 0.0 1.0100 -0.8 -0.8 0.0
Decreased48613888048613888 7.0 -1.8 -8.7 -127.8NA -0.4 -2.3 -1.9
Sites found for donor
No Change 48613905 -1748613888 2.5 2.5 0.0 1.0100 -1.7 -1.7 0.0
No Change 48613877 1148613888 5.7 5.7 0.0 1.0100 -0.7 -0.7 0.0
No Change 48613871 1748613888 1.4 1.4 0.0 1.0100 -2.0 -2.0 0.0



IVS22+3A>G


Instruction: t48614010c ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 48614033 -2148614012 4.8 4.8 0.0 1.0100 -0.9 -0.9 0.0
No Change 48614013 -148614012 0.8 0.8 0.0 1.0100 -1.8 -1.8 0.0
Sites found for donor
No Change 48614056 -4448614012 3.1 3.1 0.0 1.0100 -1.5 -1.5 0.0
No Change 48614029 -1748614012 1.6 1.6 0.0 1.0100 -1.9 -1.9 0.0
Decreased48614012 0 48614012 6.7 6.3 -0.4 -1.375.7 -0.4 -0.5 -0.1



IVS25-1G>A


Instruction: c48612488t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Increased 48612490 -248612488 5.0 5.1 0.0 1.0103.1 -0.8 -0.8 0.0
Decreased48612488 0 48612488 13.8 6.3 -7.6 -191.10.5 1.1 -0.6 -1.7
Increased 48612487 148612488 0.0 8.2 8.2 286.228616.6 -1.9 -0.1 1.8
Increased 48612484 448612488 2.2 2.5 0.3 1.2123.3 -1.4 -1.4 0.1
Sites found for donor
Increased 48612486 248612488 0.5 2.8 2.3 4.9489.0 -2.3 -1.6 0.7
No Change 48612477 1148612488 1.8 1.8 0.0 1.0100 -1.9 -1.9 0.0
No Change 48612468 2048612488 1.4 1.4 0.0 1.0100 -2.0 -2.0 0.0
No Change 48612459 2948612488 2.5 2.5 0.0 1.0100 -1.7 -1.7 0.0



IVS26+1G>A


Instruction: c48612433t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Increased 48612409 2448612433 2.0 2.4 0.4 1.3130.5 -1.5 -1.4 0.1
No Change 48612398 3548612433 3.2 3.2 0.0 1.0100 -1.2 -1.2 0.0
No Change 48612396 3748612433 3.8 3.8 0.0 1.0100 -1.1 -1.1 0.0
No Change 48612393 4048612433 4.3 4.3 0.0 1.0100 -1.0 -1.0 0.0
No Change 48612388 4548612433 3.1 3.1 0.0 1.0100 -1.3 -1.3 0.0
No Change 48612387 4648612433 1.0 1.0 0.0 1.0100 -1.7 -1.7 0.0
No Change 48612384 4948612433 1.4 1.4 0.0 1.0100 -1.6 -1.6 0.0
Sites found for donor
No Change 48612477 -4448612433 1.8 1.8 0.0 1.0100 -1.9 -1.9 0.0
No Change 48612468 -3548612433 1.4 1.4 0.0 1.0100 -2.0 -2.0 0.0
No Change 48612459 -2648612433 2.5 2.5 0.0 1.0100 -1.7 -1.7 0.0
No Change 48612429 448612433 0.8 0.8 0.0 1.0100 -2.2 -2.2 0.0
Decreased48612433048612433 5.4 -7.4 -12.8 -42.4NA -0.8 -4.7 -3.9



IVS26+1G>T


Instruction: c48612433a ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Increased 48612409 2448612433 2.0 2.9 0.8 1.8179.6 -1.5 -1.3 0.2
No Change 48612398 3548612433 3.2 3.2 0.0 1.0100 -1.2 -1.2 0.0
No Change 48612396 3748612433 3.8 3.8 0.0 1.0100 -1.1 -1.1 0.0
No Change 48612393 4048612433 4.3 4.3 0.0 1.0100 -1.0 -1.0 0.0
No Change 48612388 4548612433 3.1 3.1 0.0 1.0100 -1.3 -1.3 0.0
No Change 48612387 4648612433 1.0 1.0 0.0 1.0100 -1.7 -1.7 0.0
No Change 48612384 4948612433 1.4 1.4 0.0 1.0100 -1.6 -1.6 0.0
increased48612429448612433 -2.0 1.1 3.1 2.2219.3 -2.4 -1.7 0.7
Sites found for donor
No Change 48612477 -4448612433 1.8 1.8 0.0 1.0100 -1.9 -1.9 0.0
No Change 48612468 -3548612433 1.4 1.4 0.0 1.0100 -2.0 -2.0 0.0
No Change 48612459 -2648612433 2.5 2.5 0.0 1.0100 -1.7 -1.7 0.0
No Change 48612429 448612433 0.8 0.8 0.0 1.0100 -2.2 -2.2 0.0
Decreased48612433048612433 5.4 -2.4 -7.8 -42.4NA -0.8 -3.2 -2.4



IVS26-2A>C


Instruction: t48612292g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Decreased48612294 -3 48612291 4.5 4.1 -0.5 -1.472.3 -0.9 -1.1 -0.1
Decreased48612291 0 48612291 15.4 8.0 -7.4 -171.70.5 1.4 -0.2 -1.6
Increased 48612290 148612291 1.3 5.5 4.2 18.71870.1 -1.7 -0.7 0.9
increased486122811048612291 -0.6 1.5 2.0 2.8280.8 -2.1 -1.6 0.4
increased486122751648612291 -0.2 1.0 1.2 2.0196.5 -2.0 -1.7 0.3
Sites found for donor
No Change 48612271 2048612291 0.8 0.8 0.0 1.0100 -2.2 -2.2 0.0



IVS27-1G>C


Instruction: c48612134g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 48612159 -2548612134 1.6 1.6 0.0 1.0100 -1.6 -1.6 0.0
No Change 48612150 -1648612134 5.4 5.4 0.0 1.0100 -0.8 -0.8 0.0
Decreased48612134 0 48612134 8.8 1.6 -7.3 -156.40.6 -0.0 -1.6 -1.6
Sites found for donor
No Change 48612159 -2548612134 2.7 2.7 0.0 1.0100 -1.6 -1.6 0.0
No Change 48612123 1148612134 1.6 1.6 0.0 1.0100 -2.0 -2.0 0.0
No Change 48612114 2048612134 6.2 6.2 0.0 1.0100 -0.5 -0.5 0.0



IVS41+4A>C


Instruction: t48608339g ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
Increased 48608316 2648608342 1.7 2.2 0.5 1.4143.5 -1.6 -1.4 0.1
No Change 48608307 3548608342 4.2 4.2 0.0 1.0100 -1.0 -1.0 0.0
Sites found for donor
No Change 48608359 -1748608342 6.5 6.5 0.0 1.0100 -0.5 -0.5 0.0
No Change 48608347 -548608342 5.4 5.4 0.0 1.0100 -0.8 -0.8 0.0
Decreased48608342 0 48608342 9.8 6.7 -3.1 -8.411.9 0.5 -0.4 -0.9



IVS47+1G>A


Instruction: c48606454t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 48606447 748606454 2.0 2.0 0.0 1.0100 -1.5 -1.5 0.0
Increased 48606431 2348606454 0.9 1.2 0.3 1.2124.0 -1.7 -1.7 0.1
No Change 48606426 2848606454 0.9 0.9 0.0 1.0100 -1.7 -1.7 0.0
No Change 48606416 3848606454 8.3 8.3 0.0 1.0100 -0.1 -0.1 0.0
No Change 48606407 4748606454 2.2 2.2 0.0 1.0100 -1.5 -1.5 0.0
Sites found for donor
No Change 48606471 -1748606454 4.9 4.9 0.0 1.0100 -1.0 -1.0 0.0
Decreased48606454048606454 3.0 -9.8 -12.8 -8.2NA -1.5 -5.4 -3.9



IVS47-3C>G


Instruction: g48606365c ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 48606368 -548606363 4.6 4.6 0.0 1.0100 -0.9 -0.9 0.0
Decreased48606363 0 48606363 15.2 9.3 -6.0 -62.71.5 1.4 0.1 -1.3
Decreased48606362 1 48606363 0.5 0.3 -0.2 -1.286.5 -1.8 -1.9 -0.0
No Change 48606335 2848606363 3.1 3.1 0.0 1.0100 -1.3 -1.3 0.0
No Change 48606326 3748606363 3.4 3.4 0.0 1.0100 -1.2 -1.2 0.0
No Change 48606316 4748606363 10.3 10.3 0.0 1.0100 0.3 0.3 0.0
increased48606366-348606363 -0.2 1.7 1.9 3.3333.4 -2.0 -1.6 0.4
increased48606365-248606363 -1.4 5.9 7.3 59.05899.3 -2.2 -0.7 1.6
Sites found for donor
No Change 48606393 -3048606363 5.2 5.2 0.0 1.0100 -0.9 -0.9 0.0



IVS48+1G>A


Instruction: c48606079t ; Sequence Walker  
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Sites found for acceptor
No Change 48606105 -2648606079 3.1 3.1 0.0 1.0100 -1.3 -1.3 0.0
No Change 48606045 3448606079 3.1 3.1 0.0 1.0100 -1.3 -1.3 0.0
No Change 48606040 3948606079 4.3 4.3 0.0 1.0100 -1.0 -1.0 0.0
No Change 48606036 4348606079 3.0 3.0 0.0 1.0100 -1.3 -1.3 0.0
No Change 48606031 4848606079 10.0 10.0 0.0 1.0100 0.2 0.2 0.0
Sites found for donor
Decreased48606079048606079 8.2 -4.6 -12.8 -299.8NA 0.1 -3.8 -3.9
increased48606082-348606079 -0.9 1.7 2.6 3.2322.7 -2.7 -1.9 0.8