Gene: COL3A1
mRNA Accession: X14420
Mutation:COL3A1.txt
Chromosome: chr 2

Sequence Walker  




IVS13+2T>A


Instruction: t189820473a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 189820472 0 189820472 1.9 3.1 1.3 2.4 240.1 -1.5 -1.3 0.3



IVS17+2TA>AG


Instruction: i189822832,189822835ag; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 189822853 21 189822832 4.9 3.8 -1.1 -2.1 47.2 -0.9 -1.1 -0.2
No change 189822868 36 189822832 1.6 1.6 0.0 1.0 100 -1.6 -1.6 0.0
No change 189822870 38 189822832 3.1 3.1 0.0 1.0 100 -1.3 -1.3 0.0



IVS36+1G>C


Instruction: g189831812c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 189831785 -27 189831812 3.3 3.3 0.0 1.0 100 -1.2 -1.2 0.0
Increased 189831834 22 189831812 3.5 4.4 0.9 1.9 192.0 -1.2 -1.0 0.2
No change 189831839 27 189831812 2.7 2.7 0.0 1.0 100 -1.3 -1.3 0.0
No change 189831843 31 189831812 2.6 2.6 0.0 1.0 100 -1.4 -1.4 0.0
No change 189831847 35 189831812 0.6 0.6 0.0 1.0 100 -1.8 -1.8 0.0
No change 189831850 38 189831812 0.3 0.3 0.0 1.0 100 -1.9 -1.9 0.0
No change 189831864 52 189831812 2.1 2.1 0.0 1.0 100 -1.5 -1.5 0.0



IVS9-2A>G


Instruction: a189819054g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 189819055 0 189819055 10.3 2.1 -8.2 -286.2 0.3 0.3 -1.5 -1.8
Increased 189819065 10 189819055 2.3 2.6 0.3 1.3 125.6 -1.4 -1.4 0.1
Decreased 189819056 1 189819055 1.0 -0.8 -1.7 -2.0 NA -1.7 -2.1 -0.4
Increased 189819054 -1 189819055 -5.6 2.0 7.6 4.0 401.1 -3.2 -1.5 1.7

Legend:    Site Abolished   Leaky Site   Cryptic Site created   Strengthened Pre-existing site   Pre-existing Site   Weakened Pre-existing Site