Gene: CHM
mRNA Accession: X78121
Mutation:CHM.txt
Chromosome: chr X

Sequence Walker  




47delC


Instruction: d83338249,83338249; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83338296 -80 83338216 4.6 4.6 0.0 1.0 100 -1.0 -1.0 0.0
No change 83338235 -19 83338216 2.9 2.9 0.0 1.0 100 -1.5 -1.5 0.0
No change 83338229 -13 83338216 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
No change 83338216 0 83338216 7.7 7.7 0.0 1.0 100 -0.1 -0.1 0.0
No change 83338202 14 83338216 3.0 3.0 0.0 1.0 100 -1.5 -1.5 0.0



79+1G>A


Instruction: c83338216t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83338235 -19 83338216 2.9 2.9 0.0 1.0 100 -1.5 -1.5 0.0
No change 83338229 -13 83338216 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
No change 83338202 14 83338216 3.0 3.0 0.0 1.0 100 -1.5 -1.5 0.0
Decreased 83338216 0 83338216 7.7 -5.1 -12.8 -214.9 NA -0.1 -4.0 -3.9



146+1G>A


Instruction: c83318223t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83318251 -28 83318223 0.6 0.6 0.0 1.0 100 -2.3 -2.3 0.0
No change 83318244 -21 83318223 2.0 2.0 0.0 1.0 100 -1.8 -1.8 0.0
Decreased 83318223 0 83318223 4.4 -8.4 -12.8 -21.6 NA -1.1 -5.0 -3.9



160G>T


Instruction: c83272529a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83272525 18 83272543 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0



555_556delAG


Instruction: d83254575,83254576; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83254596 191 83254787 5.4 5.4 0.0 1.0 100 -0.8 -0.8 0.0
No change 83254589 198 83254787 1.8 1.8 0.0 1.0 100 -1.9 -1.9 0.0
Increased 83254581 206 83254787 3.0 3.3 0.4 1.3 128.8 -1.5 -1.4 0.1
No change 83254556 231 83254787 1.6 1.6 0.0 1.0 100 -1.9 -1.9 0.0
No change 83254541 246 83254787 2.2 2.2 0.0 1.0 100 -1.8 -1.8 0.0



559delG


Instruction: d83254572,83254572; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83254596 -198 83254398 5.4 5.4 0.0 1.0 100 -0.8 -0.8 0.0
No change 83254589 -191 83254398 1.8 1.8 0.0 1.0 100 -1.9 -1.9 0.0
No change 83254581 -183 83254398 3.0 3.0 0.0 1.0 100 -1.5 -1.5 0.0
No change 83254556 -158 83254398 1.6 1.6 0.0 1.0 100 -1.9 -1.9 0.0
No change 83254541 -143 83254398 2.2 2.2 0.0 1.0 100 -1.8 -1.8 0.0



579_587delTGATAAAACinsAGTTTTCT


Instruction: i83254544,83254554agaaaact; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 83254581 -183 83254398 3.0 1.8 -1.1 -2.2 45.5 -1.5 -1.9 -0.3
Decreased 83254589 -191 83254398 1.8 -9.6 -11.4 -3.6 NA -1.9 -5.3 -3.5
Decreased 83254556 -158 83254398 1.6 -18.9 -20.5 -3.0 NA -1.9 -8.2 -6.2
Decreased 83254541 -143 83254398 2.2 2.2 0.0 1.0 100 -1.8 -1.8 0.0
Decreased 83254511 -113 83254398 0.3 0.3 0.0 1.0 100 -2.3 -2.3 0.0
Decreased 83254503 -105 83254398 1.8 1.8 0.0 1.0 100 -1.9 -1.9 0.0
Increased 83254573 -175 83254398 -3.0 3.0 6.0 7.9 788.8 -3.4 -1.5 1.8
Increased 83254548 -150 83254398 -16.8 6.2 23.0 73.9 7385.9 -7.5 -0.5 7.0
Increased 83254542 -144 83254398 -21.2 2.2 23.4 4.5 449.9 -8.9 -1.8 7.1
Increased 83254512 -114 83254398 -22.7 0.3 23.0 1.2 121.6 -9.3 -2.3 7.0
Increased 83254504 -106 83254398 -19.5 1.8 21.3 3.6 358.9 -8.4 -1.9 6.5



599C>G


Instruction: g83254532c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83254581 -183 83254398 3.0 3.0 0.0 1.0 100 -1.5 -1.5 0.0
No change 83254556 -158 83254398 1.6 1.6 0.0 1.0 100 -1.9 -1.9 0.0
No change 83254541 -143 83254398 2.2 2.2 0.0 1.0 100 -1.8 -1.8 0.0
No change 83254511 -113 83254398 0.3 0.3 0.0 1.0 100 -2.3 -2.3 0.0
No change 83254503 -105 83254398 1.8 1.8 0.0 1.0 100 -1.9 -1.9 0.0



682_685delTCAC


Instruction: d83254446,83254449; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83254430 357 83254787 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
No change 83254426 361 83254787 0.1 0.1 0.0 1.0 100 -2.4 -2.4 0.0
No change 83254398 389 83254787 12.6 12.6 0.0 1.0 100 1.4 1.4 0.0



745C>T


Instruction: g83249699a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83249733 -21 83249712 1.7 1.7 0.0 1.0 100 -1.9 -1.9 0.0
No change 83249663 49 83249712 4.5 4.5 0.0 1.0 100 -1.1 -1.1 0.0



757delAAinsT


Instruction: d83249686,83249687; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83249733 -21 83249712 1.7 1.7 0.0 1.0 100 -1.9 -1.9 0.0
No change 83249663 49 83249712 4.5 4.5 0.0 1.0 100 -1.1 -1.1 0.0



787C>T


Instruction: g83249657a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 83249663 49 83249712 4.5 4.2 -0.3 -1.2 80.2 -1.1 -1.1 -0.1



798delG


Instruction: d83249646,83249646; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83249663 -69 83249594 4.5 4.5 0.0 1.0 100 -1.1 -1.1 0.0



829C>T


Instruction: g83249615a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83249663 -69 83249594 4.5 4.5 0.0 1.0 100 -1.1 -1.1 0.0
No change 83249594 0 83249594 4.0 4.0 0.0 1.0 100 -1.2 -1.2 0.0
No change 83249573 21 83249594 3.6 3.6 0.0 1.0 100 -1.3 -1.3 0.0



838C>T


Instruction: g83249606a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83249594 0 83249594 4.0 4.0 0.0 1.0 100 -1.2 -1.2 0.0
No change 83249573 21 83249594 3.6 3.6 0.0 1.0 100 -1.3 -1.3 0.0



907C>T


Instruction: g83248652a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83248661 49 83248710 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0
No change 83248624 86 83248710 1.4 1.4 0.0 1.0 100 -2.0 -2.0 0.0
Increased 83248653 57 83248710 -1.5 6.0 7.5 64.0 6403.2 -2.9 -0.6 2.3



934delT


Instruction: d83248625,83248625; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83248661 -73 83248588 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0
No change 83248624 -36 83248588 1.4 1.4 0.0 1.0 100 -2.0 -2.0 0.0
No change 83248588 0 83248588 5.0 5.0 0.0 1.0 100 -0.9 -0.9 0.0



970+1G>T


Instruction: c83248588a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83248624 -36 83248588 1.4 1.4 0.0 1.0 100 -2.0 -2.0 0.0
No change 83248572 16 83248588 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0
Decreased 83248588 0 83248588 5.0 -2.8 -7.8 -32.7 NA -0.9 -3.3 -2.4
Increased 83248589 -1 83248588 -7.6 0.6 8.2 1.5 148.3 -4.8 -2.3 2.5



1248C>A


Instruction: g83202021t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83202069 -75 83201994 2.8 2.8 0.0 1.0 100 -1.6 -1.6 0.0
No change 83202055 -61 83201994 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0
No change 83201994 0 83201994 8.3 8.3 0.0 1.0 100 0.1 0.1 0.0
No change 83201979 15 83201994 2.2 2.2 0.0 1.0 100 -1.8 -1.8 0.0
Increased 83202024 -30 83201994 -0.5 2.6 3.1 6.1 612.4 -2.6 -1.6 0.9



1274+1G>A


Instruction: c83201994t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83201979 15 83201994 2.2 2.2 0.0 1.0 100 -1.8 -1.8 0.0
Decreased 83201994 0 83201994 8.3 -4.5 -12.8 -315.2 NA 0.1 -3.8 -3.9



1319delA


Instruction: d83191878,83191878; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83191920 3 83191923 3.3 3.3 0.0 1.0 100 -1.4 -1.4 0.0
No change 83191896 27 83191923 3.0 3.0 0.0 1.0 100 -1.5 -1.5 0.0
No change 83191838 85 83191923 0.6 0.6 0.0 1.0 100 -2.2 -2.2 0.0
No change 83191830 93 83191923 3.8 3.8 0.0 1.0 100 -1.3 -1.3 0.0



1380-6T>G


Instruction: a83191449c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83191431 13 83191444 0.1 0.1 0.0 1.0 100 -2.4 -2.4 0.0



1380-1G>A


Instruction: c83191444t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83191431 13 83191444 0.1 0.1 0.0 1.0 100 -2.4 -2.4 0.0



1393delG

Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z )Δ Z
Decreased 83191431 13 83191444 0.1 -5.0 -5.1 -1.1 NA -2.4 -3.9 -1.5



1542T>A


Instruction: a83169796t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83169847 -49 83169798 2.4 2.4 0.0 1.0 100 -1.7 -1.7 0.0
No change 83169834 -36 83169798 0.2 0.2 0.0 1.0 100 -2.4 -2.4 0.0



1614_1618delTGTT


Instruction: d83169720,83169724; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83169740 58 83169798 0.0 0.0 0.0 1.0 100 -2.4 -2.4 0.0
No change 83169698 100 83169798 9.5 9.5 0.0 1.0 100 0.5 0.5 0.0



1633G>T


Instruction: c83169705a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83169740 -42 83169698 0.0 0.0 0.0 1.0 100 -2.4 -2.4 0.0
No change 83169698 0 83169698 9.5 9.5 0.0 1.0 100 0.5 0.5 0.0
No change 83169669 29 83169698 0.9 0.9 0.0 1.0 100 -2.2 -2.2 0.0
No change 83169664 34 83169698 6.9 6.9 0.0 1.0 100 -0.3 -0.3 0.0
No change 83169659 39 83169698 3.9 3.9 0.0 1.0 100 -1.3 -1.3 0.0
Increased 83169706 -8 83169698 -5.0 3.2 8.2 9.0 902.9 -4.0 -1.5 2.5



1693A>T


Instruction: t83163893a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83163935 12 83163947 2.0 2.0 0.0 1.0 100 -1.8 -1.8 0.0
No change 83163915 32 83163947 0.9 0.9 0.0 1.0 100 -2.2 -2.2 0.0
Increased 83163894 53 83163947 -2.5 5.3 7.8 39.4 3936.4 -3.2 -0.8 2.4

Legend:    Site Abolished   Leaky Site   Cryptic Site created   Strengthened Pre-existing site   Pre-existing Site   Weakened Pre-existing Site