Gene: CHM
mRNA Accession: X78121
Mutation:CHM.txt
Chromosome: chr X

Sequence Walker  




47delC


Instruction: d83338249,83338249; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83338266 -50 83338216 2.8 2.8 0.0 1.0 100 -1.3 -1.3 0.0
Decreased 83338242 -26 83338216 0.3 -0.2 -0.6 -1.2 NA -1.9 -2.0 -0.1



79+1G>A


Instruction: c83338216t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83338242 -26 83338216 0.3 0.3 0.0 1.0 100 -1.9 -1.9 0.0



146+1G>A


Instruction: c83318223t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83318174 49 83318223 7.5 7.5 0.0 1.0 100 -0.3 -0.3 0.0



160G>T


Instruction: c83272529a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83272554 -11 83272543 0.4 0.4 0.0 1.0 100 -1.9 -1.9 0.0
No change 83272553 -10 83272543 2.3 2.3 0.0 1.0 100 -1.4 -1.4 0.0
No change 83272552 -9 83272543 8.7 8.7 0.0 1.0 100 -0.0 -0.0 0.0
No change 83272551 -8 83272543 4.4 4.4 0.0 1.0 100 -1.0 -1.0 0.0
No change 83272550 -7 83272543 0.2 0.2 0.0 1.0 100 -1.9 -1.9 0.0
No change 83272549 -6 83272543 6.5 6.5 0.0 1.0 100 -0.5 -0.5 0.0
No change 83272545 -2 83272543 3.5 3.5 0.0 1.0 100 -1.2 -1.2 0.0
No change 83272543 0 83272543 12.1 12.1 0.0 1.0 100 0.7 0.7 0.0
No change 83272540 3 83272543 3.5 3.5 0.0 1.0 100 -1.2 -1.2 0.0
No change 83272499 44 83272543 8.0 8.0 0.0 1.0 100 -0.2 -0.2 0.0
No change 83272479 64 83272543 3.3 3.3 0.0 1.0 100 -1.2 -1.2 0.0



555_556delAG


Instruction: d83254575,83254576; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83254524 263 83254787 3.7 3.7 0.0 1.0 100 -1.1 -1.1 0.0



559delG


Instruction: d83254572,83254572; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83254524 -126 83254398 3.7 3.7 0.0 1.0 100 -1.1 -1.1 0.0
No change 83254521 -123 83254398 3.3 3.3 0.0 1.0 100 -1.2 -1.2 0.0



579_587delTGATAAAACinsAGTTTTCT

Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z )Δ Z
Decreased 83254524 -126 83254398 3.7 5.7 2.0 4.1 407.7 -1.1 -0.7 0.4
Decreased 83254521 -123 83254398 3.3 4.1 0.8 1.7 174.5 -1.2 -1.0 0.2
Increased 83254525 -127 83254398 -13.8 5.7 19.5 52.9 5289.7 -4.9 -0.7 4.3
Increased 83254522 -124 83254398 -15.1 4.1 19.2 17.3 1731.9 -5.2 -1.0 4.2



599C>G


Instruction: g83254532c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 83254524 -126 83254398 3.7 2.1 -1.6 -3.0 32.9 -1.1 -1.5 -0.4
Decreased 83254521 -123 83254398 3.3 1.6 -1.7 -3.3 30.3 -1.2 -1.6 -0.4



682_685delTCAC


Instruction: d83254446,83254449; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83254399 388 83254787 1.1 1.1 0.0 1.0 100 -1.7 -1.7 0.0



745C>T


Instruction: g83249699a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83249714 -2 83249712 0.5 0.5 0.0 1.0 100 -1.8 -1.8 0.0
No change 83249712 0 83249712 8.0 8.0 0.0 1.0 100 -0.2 -0.2 0.0
Decreased 83249696 16 83249712 3.1 2.8 -0.3 -1.2 82.3 -1.3 -1.3 -0.1
No change 83249648 64 83249712 2.4 2.4 0.0 1.0 100 -1.4 -1.4 0.0



757delAAinsT


Instruction: d83249686,83249687; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83249714 -2 83249712 0.5 0.5 0.0 1.0 100 -1.8 -1.8 0.0
No change 83249712 0 83249712 8.0 8.0 0.0 1.0 100 -0.2 -0.2 0.0
No change 83249696 16 83249712 3.1 3.1 0.0 1.0 100 -1.3 -1.3 0.0
No change 83249648 64 83249712 2.4 2.4 0.0 1.0 100 -1.4 -1.4 0.0



787C>T


Instruction: g83249657a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 83249648 64 83249712 2.4 3.0 0.6 1.5 149.8 -1.4 -1.3 0.1
No change 83249612 100 83249712 2.3 2.3 0.0 1.0 100 -1.4 -1.4 0.0
No change 83249609 103 83249712 0.9 0.9 0.0 1.0 100 -1.7 -1.7 0.0



798delG


Instruction: d83249646,83249646; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 83249648 -54 83249594 2.4 2.9 0.5 1.4 142.8 -1.4 -1.3 0.1
No change 83249612 -18 83249594 2.3 2.3 0.0 1.0 100 -1.4 -1.4 0.0
No change 83249609 -15 83249594 0.9 0.9 0.0 1.0 100 -1.7 -1.7 0.0



829C>T


Instruction: g83249615a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 83249612 -18 83249594 2.3 2.0 -0.3 -1.2 82.3 -1.4 -1.5 -0.1
Increased 83249609 -15 83249594 0.9 1.0 0.2 1.1 111.1 -1.7 -1.7 0.0



838C>T


Instruction: g83249606a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83249612 -18 83249594 2.3 2.3 0.0 1.0 100 -1.4 -1.4 0.0
No change 83249609 -15 83249594 0.9 0.9 0.0 1.0 100 -1.7 -1.7 0.0



970+1G>T


Instruction: c83248588a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 83248572 16 83248588 2.4 3.8 1.4 2.6 259.7 -1.4 -1.1 0.3
Increased 83248569 19 83248588 3.0 4.1 1.1 2.1 214.2 -1.3 -1.0 0.2



1248C>A


Instruction: g83202021t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83202029 -35 83201994 7.0 7.0 0.0 1.0 100 -0.4 -0.4 0.0
No change 83202024 -30 83201994 5.7 5.7 0.0 1.0 100 -0.7 -0.7 0.0
Decreased 83202014 -20 83201994 2.4 0.5 -1.9 -3.8 26.2 -1.4 -1.8 -0.4



1274+1G>A


Instruction: c83201994t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83202014 -20 83201994 2.4 2.4 0.0 1.0 100 -1.4 -1.4 0.0



1319delA


Instruction: d83191878,83191878; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Increased 83191862 61 83191923 2.5 4.0 1.4 2.7 272.0 -1.4 -1.1 0.3



1380-6T>G


Instruction: a83191449c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 83191444 0 83191444 9.9 7.0 -2.8 -7.2 13.9 0.2 -0.4 -0.6
Decreased 83191440 4 83191444 3.7 1.5 -2.2 -4.6 21.8 -1.1 -1.6 -0.5
Decreased 83191432 12 83191444 1.7 0.1 -1.5 -2.9 34.2 -1.6 -1.9 -0.3
No change 83191415 29 83191444 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
Increased 83191449 -5 83191444 -0.9 7.8 8.7 226.1 22612.7 -2.1 -0.2 1.9



1380-1G>A


Instruction: c83191444t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 83191444 0 83191444 9.9 2.3 -7.6 -191.1 0.5 0.2 -1.4 -1.7
Increased 83191440 4 83191444 3.7 4.0 0.3 1.2 123.3 -1.1 -1.1 0.1
Decreased 83191432 12 83191444 1.7 1.2 -0.5 -1.4 70.1 -1.6 -1.7 -0.1
No change 83191415 29 83191444 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
Increased 83191443 1 83191444 -6.3 1.8 8.2 3.6 357.0 -3.3 -1.5 1.8



1393delG


Instruction: d83191430,83191430; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 83191444 0 83191444 9.9 9.9 0.0 1.0 100 0.2 0.2 0.0
No change 83191440 4 83191444 3.7 3.7 0.0 1.0 100 -1.1 -1.1 0.0
Decreased 83191432 12 83191444 1.7 1.3 -0.4 -1.3 74.5 -1.6 -1.7 -0.1
Increased 83191415 29 83191444 1.4 2.2 0.8 1.7 173.5 -1.6 -1.5 0.2
No change 83191380 64 83191444 0.5 0.5 0.0 1.0 100 -1.8 -1.8 0.0



1542T>A


Instruction: a83169796t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
Decreased 83169798 0 83169798 10.3 9.8 -0.5 -1.4 72.2 0.3 0.2 -0.1
Decreased 83169776 22 83169798 1.0 0.1 -0.9 -1.9 53.7 -1.7 -1.9 -0.2
No change 83169762 36 83169798 2.9 2.9 0.0 1.0 100 -1.3 -1.3 0.0



1542T>A

Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z )Δ Z
Increased 83169703 95 83169798 -3.9 0.5 4.3 1.4 136.7 -2.8 -1.8 0.9



1542T>A

Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z )Δ Z
Increased 83163871 5927 83169798 -0.3 0.2 0.5 1.1 111.2 -2.0 -1.9 0.1

Legend:    Site Abolished   Leaky Site   Cryptic Site created   Strengthened Pre-existing site   Pre-existing Site   Weakened Pre-existing Site