Gene: BRCA2
mRNA Accession: U43746
Mutation:BRCA2.txt
Chromosome: chr 13

Sequence Walker  




1742T>C


Instruction: t31843765c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 31843748 -413 31844161 11.4 11.4 0.0 1.0 100 0.5 0.5 0.0
No change 31843749 -412 31844161 1.1 1.1 0.0 1.0 100 -1.7 -1.7 0.0
No change 31843815 -346 31844161 4.4 4.4 0.0 1.0 100 -1.0 -1.0 0.0



6893A>G


Instruction: a31851793g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 31851778 -192 31851970 0.7 0.7 0.0 1.0 100 -1.8 -1.8 0.0
No change 31851780 -190 31851970 4.6 4.6 0.0 1.0 100 -0.9 -0.9 0.0
No change 31851786 -184 31851970 2.0 2.0 0.0 1.0 100 -1.5 -1.5 0.0



5416A>T


Instruction: a31850316t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 31850356 -1614 31851970 0.2 0.2 0.0 1.0 100 -1.9 -1.9 0.0



4035T>C


Instruction: t31848935c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 31848916 1879 31847037 0.9 0.9 0.0 1.0 100 -1.7 -1.7 0.0
Decreased 31848950 1913 31847037 3.1 2.8 -0.2 -1.2 86.1 -1.3 -1.3 -0.0
Decreased 31848954 1917 31847037 0.5 0.2 -0.3 -1.2 80.4 -1.8 -1.9 -0.1



6631A>C


Instruction: a31851531c; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 31851558 -412 31851970 3.0 3.0 0.0 1.0 100 -1.3 -1.3 0.0
Increased 31851546 -424 31851970 -1.1 0.2 1.3 1.2 118.0 -2.2 -1.9 0.3



9179C>G


Instruction: c31890286g; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 31890318 29 31890289 6.0 6.0 0.0 1.0 100 -0.6 -0.6 0.0



5972C>T


Instruction: c31850872t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 31850853 -1117 31851970 4.8 4.8 0.0 1.0 100 -0.9 -0.9 0.0
No change 31850903 -1067 31851970 4.8 4.8 0.0 1.0 100 -0.9 -0.9 0.0



6174delT


Instruction: d31851074,31851074; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 31851064 -906 31851970 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
No change 31851069 -901 31851970 2.4 2.4 0.0 1.0 100 -1.4 -1.4 0.0



5909insA


Instruction: i31850809,31850810a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 31850853 -1117 31851970 4.8 4.8 0.0 1.0 100 -0.9 -0.9 0.0



6630delTAACT


Instruction: d31851526,31851530; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 31851558 -412 31851970 3.0 3.0 0.0 1.0 100 -1.3 -1.3 0.0
Increased 31851546 -424 31851970 -1.1 0.1 1.2 1.1 105.1 -2.2 -1.9 0.3

Legend:    Site Abolished   Leaky Site   Cryptic Site created   Strengthened Pre-existing site   Pre-existing Site   Weakened Pre-existing Site