Gene: SPAST
mRNA Accession: AJ246001
Mutation:SPAST.txt
Chromosome: chr 2

Sequence Walker  




334G>T


Instruction: g32246944t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 32246932 -94 32247026 2.5 2.5 0.0 1.0 100 -1.7 -1.7 0.0
No change 32246985 -41 32247026 0.6 0.6 0.0 1.0 100 -2.3 -2.3 0.0
Decreased 32246942 -84 32247026 0.2 -3.9 -4.1 -1.2 NA -2.4 -3.6 -1.2



1005-1G>T


Instruction: g32298897t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 32298930 33 32298897 1.1 1.1 0.0 1.0 100 -2.1 -2.1 0.0



1134_1135delGT


Instruction: d32309762,32309763; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 32309712 -14 32309726 2.9 2.9 0.0 1.0 100 -1.6 -1.6 0.0
No change 32309788 62 32309726 0.4 0.4 0.0 1.0 100 -2.3 -2.3 0.0
No change 32309802 76 32309726 9.8 9.8 0.0 1.0 100 0.5 0.5 0.0



1508G>T


Instruction: g32324697t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 32324662 -20 32324682 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
Increased 32324699 17 32324682 4.2 4.4 0.2 1.1 112.3 -1.1 -1.1 0.1
No change 32324726 44 32324682 8.5 8.5 0.0 1.0 100 0.1 0.1 0.0
No change 32324730 48 32324682 1.2 1.2 0.0 1.0 100 -2.1 -2.1 0.0



1577_1580delGAAG


Instruction: d32326155,32326158; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 32326146 32 32326114 2.9 2.9 0.0 1.0 100 -1.6 -1.6 0.0
No change 32326195 81 32326114 10.7 10.7 0.0 1.0 100 0.8 0.8 0.0
No change 32326199 85 32326114 1.3 1.3 0.0 1.0 100 -2.0 -2.0 0.0
Decreased 32326154 40 32326114 1.3 -2.2 -3.5 -2.4 NA -2.1 -3.1 -1.1



1720delG


Instruction: d32330029,32330029; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 32330014 -24 32330038 7.6 7.6 0.0 1.0 100 -0.1 -0.1 0.0
No change 32330033 -5 32330038 5.5 5.5 0.0 1.0 100 -0.8 -0.8 0.0
No change 32330038 0 32330038 3.2 3.2 0.0 1.0 100 -1.5 -1.5 0.0



1728+2T>A


Instruction: t32330039a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 32330014 -24 32330038 7.6 7.6 0.0 1.0 100 -0.1 -0.1 0.0
Increased 32330033 -5 32330038 5.5 6.0 0.5 1.4 144.5 -0.8 -0.6 0.2
No change 32330079 41 32330038 5.3 5.3 0.0 1.0 100 -0.8 -0.8 0.0
Decreased 32330038 0 32330038 3.2 -4.6 -7.8 -9.2 NA -1.5 -3.8 -2.4

Legend:    Site Abolished   Leaky Site   Cryptic Site created   Strengthened Pre-existing site   Pre-existing Site   Weakened Pre-existing Site