Gene: SPAST
mRNA Accession: AJ246001
Mutation:SPAST.txt
Chromosome: chr 2

Sequence Walker  




334G>T


Instruction: g32246944t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 32246976 -50 32247026 3.0 3.0 0.0 1.0 100 -1.3 -1.3 0.0



1005-1G>T


Instruction: g32298897t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 32298872 -25 32298897 5.8 5.8 0.0 1.0 100 -0.7 -0.7 0.0
Increased 32298905 8 32298897 1.3 3.2 1.9 3.8 378.6 -1.7 -1.2 0.4
Decreased 32298897 0 32298897 3.6 -5.2 -8.7 -12.0 NA -1.2 -3.1 -1.9
Increased 32298899 2 32298897 -1.9 2.4 4.3 5.2 520.4 -2.4 -1.4 0.9



1134_1135delGT


Instruction: d32309762,32309763; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 32309736 10 32309726 9.5 9.5 0.0 1.0 100 0.1 0.1 0.0
No change 32309755 29 32309726 1.7 1.7 0.0 1.0 100 -1.6 -1.6 0.0
Decreased 32309781 55 32309726 0.0 -6.9 -6.9 -1.0 NA -1.9 -3.4 -1.5



1508G>T


Instruction: g32324697t; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 32324682 0 32324682 9.0 9.0 0.0 1.0 100 0.0 0.0 0.0



1720delG


Instruction: d32330029,32330029; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 32330075 37 32330038 2.9 2.9 0.0 1.0 100 -1.3 -1.3 0.0
No change 32330077 39 32330038 1.7 1.7 0.0 1.0 100 -1.6 -1.6 0.0
No change 32330079 41 32330038 2.0 2.0 0.0 1.0 100 -1.5 -1.5 0.0



1728+2T>A


Instruction: t32330039a; Sequence Walker
Type of changeGenomic CoordinatePosition Relative
to Natural Site
Closest
Natural Site
Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
No change 32330075 37 32330038 2.9 2.9 0.0 1.0 100 -1.3 -1.3 0.0
No change 32330077 39 32330038 1.7 1.7 0.0 1.0 100 -1.6 -1.6 0.0
No change 32330079 41 32330038 2.0 2.0 0.0 1.0 100 -1.5 -1.5 0.0
No change 32330082 44 32330038 4.0 4.0 0.0 1.0 100 -1.1 -1.1 0.0
No change 32330083 45 32330038 4.6 4.6 0.0 1.0 100 -0.9 -0.9 0.0

Legend:    Site Abolished   Leaky Site   Cryptic Site created   Strengthened Pre-existing site   Pre-existing Site   Weakened Pre-existing Site